Topographical and Chronological Analysis of Thin Cutaneous Melanoma’s Progressions: A Multicentric Study
A great portion of cutaneous melanoma’s diagnoses nowadays is attributed to thin tumors with up to 1 mm in Breslow thickness (hereafter thin CMs), which occasionally metastasize. The objective of this study was to identify thin CM’s metastatic patterns from a topographical and chronological standpoi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/15/3989 |
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| author | Emmanouil Chousakos Daniela Zugna Emi Dika Aram Boada Sebastian Podlipnik Cristina Carrera Josep Malvehy Susana Puig Celia Requena Esperanza Manrique-Silva Eduardo Nagore Pietro Quaglino Rebecca Senetta Simone Ribero |
| author_facet | Emmanouil Chousakos Daniela Zugna Emi Dika Aram Boada Sebastian Podlipnik Cristina Carrera Josep Malvehy Susana Puig Celia Requena Esperanza Manrique-Silva Eduardo Nagore Pietro Quaglino Rebecca Senetta Simone Ribero |
| author_sort | Emmanouil Chousakos |
| collection | DOAJ |
| description | A great portion of cutaneous melanoma’s diagnoses nowadays is attributed to thin tumors with up to 1 mm in Breslow thickness (hereafter thin CMs), which occasionally metastasize. The objective of this study was to identify thin CM’s metastatic patterns from a topographical and chronological standpoint. A total of 204 cases of metastatic thin CMs from five specialized centers were included in the study, and corresponding data were collected (clinical, epidemiological, histopathological information of primary tumor and the number, anatomical site, and time intervals of their progressions). First progressions occurred locally, in regional lymph nodes, and in a distant site in 24%, 15% and 61% of cases, respectively, with a median time to first progression of 3.10 years (IQR: 1.09–5.24). The median elapsed time between the first and second progression and between the second and third progression was 0.82 (IQR: 0.34–1.97) and 0.49 (IQR: 0.21–2.30) years, respectively, while the median survival time was about 4 years since first progression. Furthermore, the sequences of locations and time intervals of the progressions were associated with the clinicopathological and demographic features of the primary tumors along with the features of the preceding progressions. In conclusion, the findings of this study describe the natural history of thin CMs, thus highlighting the necessity to identify subgroups of thin CMs at a higher risk for metastasis and contributing to the optimization of the management and follow-up of thin CM patients. |
| first_indexed | 2024-03-11T00:30:13Z |
| format | Article |
| id | doaj.art-4ec2c76ad37a4187a6c1d7125c11c6ce |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T00:30:13Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-4ec2c76ad37a4187a6c1d7125c11c6ce2023-11-18T22:44:07ZengMDPI AGCancers2072-66942023-08-011515398910.3390/cancers15153989Topographical and Chronological Analysis of Thin Cutaneous Melanoma’s Progressions: A Multicentric StudyEmmanouil Chousakos0Daniela Zugna1Emi Dika2Aram Boada3Sebastian Podlipnik4Cristina Carrera5Josep Malvehy6Susana Puig7Celia Requena8Esperanza Manrique-Silva9Eduardo Nagore10Pietro Quaglino11Rebecca Senetta12Simone Ribero131st Department of Pathology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, GreeceCancer Epidemiology Unit, Department of Medical Sciences, University of Turin, 10126 Turin, ItalyOncologic Dermatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, ItalyDermatology Department, Hospital Universitari Germans Trias i Pujol, Institut d’Investigació Germans Trias i Pujol, 08916 Badalona, SpainMelanoma Unit, Dermatology Department, Hospital Clinic, Universitat de Barcelona, Institut d’ Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, SpainMelanoma Unit, Dermatology Department, Hospital Clinic, Universitat de Barcelona, Institut d’ Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, SpainMelanoma Unit, Dermatology Department, Hospital Clinic, Universitat de Barcelona, Institut d’ Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, SpainMelanoma Unit, Dermatology Department, Hospital Clinic, Universitat de Barcelona, Institut d’ Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, SpainDermatology Department, Instituto Valenciano de Oncología, 46009 Valencia, SpainDermatology Department, Instituto Valenciano de Oncología, 46009 Valencia, SpainDermatology Department, Instituto Valenciano de Oncología, 46009 Valencia, SpainDermatology Clinic, Medical Sciences Department, University of Turin, 10126 Turin, ItalyPathology Unit, Department of Oncology, University of Turin, 10124 Turin, ItalyDermatology Clinic, Medical Sciences Department, University of Turin, 10126 Turin, ItalyA great portion of cutaneous melanoma’s diagnoses nowadays is attributed to thin tumors with up to 1 mm in Breslow thickness (hereafter thin CMs), which occasionally metastasize. The objective of this study was to identify thin CM’s metastatic patterns from a topographical and chronological standpoint. A total of 204 cases of metastatic thin CMs from five specialized centers were included in the study, and corresponding data were collected (clinical, epidemiological, histopathological information of primary tumor and the number, anatomical site, and time intervals of their progressions). First progressions occurred locally, in regional lymph nodes, and in a distant site in 24%, 15% and 61% of cases, respectively, with a median time to first progression of 3.10 years (IQR: 1.09–5.24). The median elapsed time between the first and second progression and between the second and third progression was 0.82 (IQR: 0.34–1.97) and 0.49 (IQR: 0.21–2.30) years, respectively, while the median survival time was about 4 years since first progression. Furthermore, the sequences of locations and time intervals of the progressions were associated with the clinicopathological and demographic features of the primary tumors along with the features of the preceding progressions. In conclusion, the findings of this study describe the natural history of thin CMs, thus highlighting the necessity to identify subgroups of thin CMs at a higher risk for metastasis and contributing to the optimization of the management and follow-up of thin CM patients.https://www.mdpi.com/2072-6694/15/15/3989cutaneous melanomainvasive melanomametastatic melanomathin melanomamelanoma progressionsthin melanoma natural history |
| spellingShingle | Emmanouil Chousakos Daniela Zugna Emi Dika Aram Boada Sebastian Podlipnik Cristina Carrera Josep Malvehy Susana Puig Celia Requena Esperanza Manrique-Silva Eduardo Nagore Pietro Quaglino Rebecca Senetta Simone Ribero Topographical and Chronological Analysis of Thin Cutaneous Melanoma’s Progressions: A Multicentric Study Cancers cutaneous melanoma invasive melanoma metastatic melanoma thin melanoma melanoma progressions thin melanoma natural history |
| title | Topographical and Chronological Analysis of Thin Cutaneous Melanoma’s Progressions: A Multicentric Study |
| title_full | Topographical and Chronological Analysis of Thin Cutaneous Melanoma’s Progressions: A Multicentric Study |
| title_fullStr | Topographical and Chronological Analysis of Thin Cutaneous Melanoma’s Progressions: A Multicentric Study |
| title_full_unstemmed | Topographical and Chronological Analysis of Thin Cutaneous Melanoma’s Progressions: A Multicentric Study |
| title_short | Topographical and Chronological Analysis of Thin Cutaneous Melanoma’s Progressions: A Multicentric Study |
| title_sort | topographical and chronological analysis of thin cutaneous melanoma s progressions a multicentric study |
| topic | cutaneous melanoma invasive melanoma metastatic melanoma thin melanoma melanoma progressions thin melanoma natural history |
| url | https://www.mdpi.com/2072-6694/15/15/3989 |
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