Time estimation in a case of Tourette's syndrome: Effect of antipsychotic medications
Abstract Aims Dopamine (DA) hyperactivity causes overestimation of time, whereas DA hypoactivity produces its underestimation. DA activity also provides neurochemical substrates pertinent to several psychiatric conditions, such as schizophrenia and Tourette's syndrome. The overestimation of tim...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-06-01
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| Series: | Neuropsychopharmacology Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/npr2.12101 |
| _version_ | 1811301364830044160 |
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| author | Takuma Inagawa Natsuki Ueda Kazuyuki Nakagome Tomiki Sumiyoshi |
| author_facet | Takuma Inagawa Natsuki Ueda Kazuyuki Nakagome Tomiki Sumiyoshi |
| author_sort | Takuma Inagawa |
| collection | DOAJ |
| description | Abstract Aims Dopamine (DA) hyperactivity causes overestimation of time, whereas DA hypoactivity produces its underestimation. DA activity also provides neurochemical substrates pertinent to several psychiatric conditions, such as schizophrenia and Tourette's syndrome. The overestimation of time sometimes exists in patients with Tourette's syndrome, but no reports have addressed time perception in relation to antipsychotic medications which typically act as DA receptor antagonists. We herein report a case of Tourette's syndrome, in which time estimation was differentially affected by risperidone (a DA antagonist) and aripiprazole (a DA partial agonist). Case A 27‐year‐old man who suffered from verbal and motor tics was treated with risperidone. His tic symptoms disappeared; however, he began to experience a strange feeling that “time is going too fast.” For example, “people walk more quickly compared to a normal pace.” These complaints were thought to represent underestimation of time. Then, risperidone was switched to oral aripiprazole to optimize DA transmissions, which resulted in the amelioration of these subjective feelings. Conclusion Our observations indicate that the underestimation of time may occur in patients with Tourette's syndrome who receive antipsychotic drugs with high DA D2 receptor blocking potency. This may support the concept that the estimation of time is influenced by DA activity. |
| first_indexed | 2024-04-13T07:07:35Z |
| format | Article |
| id | doaj.art-4ec3457c66f8484e98a08ecd01daad00 |
| institution | Directory Open Access Journal |
| issn | 2574-173X |
| language | English |
| last_indexed | 2024-04-13T07:07:35Z |
| publishDate | 2020-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neuropsychopharmacology Reports |
| spelling | doaj.art-4ec3457c66f8484e98a08ecd01daad002022-12-22T02:56:57ZengWileyNeuropsychopharmacology Reports2574-173X2020-06-0140219820010.1002/npr2.12101Time estimation in a case of Tourette's syndrome: Effect of antipsychotic medicationsTakuma Inagawa0Natsuki Ueda1Kazuyuki Nakagome2Tomiki Sumiyoshi3Department of Psychiatry National Center Hospital National Center of Neurology and Psychiatry Tokyo JapanDepartment of Clinical Epidemiology Translational Medical Center National Center of Neurology and Psychiatry Tokyo JapanDepartment of Psychiatry National Center Hospital National Center of Neurology and Psychiatry Tokyo JapanDepartment of Preventive Intervention for Psychiatric Disorders National Center of Neurology and Psychiatry National Institute of Mental Health Tokyo JapanAbstract Aims Dopamine (DA) hyperactivity causes overestimation of time, whereas DA hypoactivity produces its underestimation. DA activity also provides neurochemical substrates pertinent to several psychiatric conditions, such as schizophrenia and Tourette's syndrome. The overestimation of time sometimes exists in patients with Tourette's syndrome, but no reports have addressed time perception in relation to antipsychotic medications which typically act as DA receptor antagonists. We herein report a case of Tourette's syndrome, in which time estimation was differentially affected by risperidone (a DA antagonist) and aripiprazole (a DA partial agonist). Case A 27‐year‐old man who suffered from verbal and motor tics was treated with risperidone. His tic symptoms disappeared; however, he began to experience a strange feeling that “time is going too fast.” For example, “people walk more quickly compared to a normal pace.” These complaints were thought to represent underestimation of time. Then, risperidone was switched to oral aripiprazole to optimize DA transmissions, which resulted in the amelioration of these subjective feelings. Conclusion Our observations indicate that the underestimation of time may occur in patients with Tourette's syndrome who receive antipsychotic drugs with high DA D2 receptor blocking potency. This may support the concept that the estimation of time is influenced by DA activity.https://doi.org/10.1002/npr2.12101dopaminetime perceptionTourette's syndrome |
| spellingShingle | Takuma Inagawa Natsuki Ueda Kazuyuki Nakagome Tomiki Sumiyoshi Time estimation in a case of Tourette's syndrome: Effect of antipsychotic medications Neuropsychopharmacology Reports dopamine time perception Tourette's syndrome |
| title | Time estimation in a case of Tourette's syndrome: Effect of antipsychotic medications |
| title_full | Time estimation in a case of Tourette's syndrome: Effect of antipsychotic medications |
| title_fullStr | Time estimation in a case of Tourette's syndrome: Effect of antipsychotic medications |
| title_full_unstemmed | Time estimation in a case of Tourette's syndrome: Effect of antipsychotic medications |
| title_short | Time estimation in a case of Tourette's syndrome: Effect of antipsychotic medications |
| title_sort | time estimation in a case of tourette s syndrome effect of antipsychotic medications |
| topic | dopamine time perception Tourette's syndrome |
| url | https://doi.org/10.1002/npr2.12101 |
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