Left ventricular strain: A reliable predictor of short-term outcomes in patients with anterior wall myocardial infarction without heart failure
Background: Left ventricular ejection fraction (LVEF) is a key determinant in decision-making after acute myocardial infarction (MI). Little is known of its relationship with left ventricular Strain and N-Terminal fragment of pro-B-type Natriuretic Peptide (NT-pro-BNP) following acute anterior wall...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2020-01-01
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| Series: | Advanced Biomedical Research |
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| Online Access: | http://www.advbiores.net/article.asp?issn=2277-9175;year=2020;volume=9;issue=1;spage=67;epage=67;aulast=Singh |
| _version_ | 1819278736080502784 |
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| author | Bonnie R K. Singh Rishi Sethi Nirdesh Jain Gaurav Chaudhry Mahim Saran Omkar Mishra Akshyaya Pradhan |
| author_facet | Bonnie R K. Singh Rishi Sethi Nirdesh Jain Gaurav Chaudhry Mahim Saran Omkar Mishra Akshyaya Pradhan |
| author_sort | Bonnie R K. Singh |
| collection | DOAJ |
| description | Background: Left ventricular ejection fraction (LVEF) is a key determinant in decision-making after acute myocardial infarction (MI). Little is known of its relationship with left ventricular Strain and N-Terminal fragment of pro-B-type Natriuretic Peptide (NT-pro-BNP) following acute anterior wall MI (AWMI). Materials and
Methods: We conducted a prospective cohort study of patients with a diagnosis of acute AWMI and the absence of overt heart failure (HF). Assessment of LVEF, strain parameters on echocardiography was done, and NT-pro-BNP levels were obtained. Follow-up for adverse cardiac events was done for 30 days postdischarge. Correlation of LVEF and NT-pro-BNP with various strain parameters were ascertained.
Results: Of the total of 50 patients of AWMI enrolled, the mean LVEF in the study was 43.46 ± 3.72%.Eleven patients (22%) had adverse events at 30 days of follow-up. Patients with adverse events had significantly higher overall peak systolic longitudinal strain (PSLS), lower mid-region peak systolic longitudinal velocity (PSLV), and basal region PSLV. A significant negative correlation was observed between LVEF and mean Peak PSLS of combined apical plus mid regions of the left ventricle (r = −0.700). Log10-NT-pro BNP also showed a strong negative correlation with overall PSLV (r = −0.792) as well as regional PSLV values of combined apical plus mid (r = −0.763) and basal segments (r = −0.748).
Conclusions: In patients with AWMI without HF, PSLS and PSLV are good predictors of adverse outcomes at 30-day follow-up. Furthermore, NT-pro BNP can also be an indirect predictor of strain parameters on echocardiography. |
| first_indexed | 2024-12-24T00:16:44Z |
| format | Article |
| id | doaj.art-4ec4804f49c94ffc881f44fd1e12d25e |
| institution | Directory Open Access Journal |
| issn | 2277-9175 |
| language | English |
| last_indexed | 2024-12-24T00:16:44Z |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Advanced Biomedical Research |
| spelling | doaj.art-4ec4804f49c94ffc881f44fd1e12d25e2022-12-21T17:24:42ZengWolters Kluwer Medknow PublicationsAdvanced Biomedical Research2277-91752020-01-0191676710.4103/abr.abr_213_18Left ventricular strain: A reliable predictor of short-term outcomes in patients with anterior wall myocardial infarction without heart failureBonnie R K. SinghRishi SethiNirdesh JainGaurav ChaudhryMahim SaranOmkar MishraAkshyaya PradhanBackground: Left ventricular ejection fraction (LVEF) is a key determinant in decision-making after acute myocardial infarction (MI). Little is known of its relationship with left ventricular Strain and N-Terminal fragment of pro-B-type Natriuretic Peptide (NT-pro-BNP) following acute anterior wall MI (AWMI). Materials and Methods: We conducted a prospective cohort study of patients with a diagnosis of acute AWMI and the absence of overt heart failure (HF). Assessment of LVEF, strain parameters on echocardiography was done, and NT-pro-BNP levels were obtained. Follow-up for adverse cardiac events was done for 30 days postdischarge. Correlation of LVEF and NT-pro-BNP with various strain parameters were ascertained. Results: Of the total of 50 patients of AWMI enrolled, the mean LVEF in the study was 43.46 ± 3.72%.Eleven patients (22%) had adverse events at 30 days of follow-up. Patients with adverse events had significantly higher overall peak systolic longitudinal strain (PSLS), lower mid-region peak systolic longitudinal velocity (PSLV), and basal region PSLV. A significant negative correlation was observed between LVEF and mean Peak PSLS of combined apical plus mid regions of the left ventricle (r = −0.700). Log10-NT-pro BNP also showed a strong negative correlation with overall PSLV (r = −0.792) as well as regional PSLV values of combined apical plus mid (r = −0.763) and basal segments (r = −0.748). Conclusions: In patients with AWMI without HF, PSLS and PSLV are good predictors of adverse outcomes at 30-day follow-up. Furthermore, NT-pro BNP can also be an indirect predictor of strain parameters on echocardiography.http://www.advbiores.net/article.asp?issn=2277-9175;year=2020;volume=9;issue=1;spage=67;epage=67;aulast=Singhechocardiographyheart failureleft ventricular strainnatriuretic peptidespeak systolic longitudinal velocity |
| spellingShingle | Bonnie R K. Singh Rishi Sethi Nirdesh Jain Gaurav Chaudhry Mahim Saran Omkar Mishra Akshyaya Pradhan Left ventricular strain: A reliable predictor of short-term outcomes in patients with anterior wall myocardial infarction without heart failure Advanced Biomedical Research echocardiography heart failure left ventricular strain natriuretic peptides peak systolic longitudinal velocity |
| title | Left ventricular strain: A reliable predictor of short-term outcomes in patients with anterior wall myocardial infarction without heart failure |
| title_full | Left ventricular strain: A reliable predictor of short-term outcomes in patients with anterior wall myocardial infarction without heart failure |
| title_fullStr | Left ventricular strain: A reliable predictor of short-term outcomes in patients with anterior wall myocardial infarction without heart failure |
| title_full_unstemmed | Left ventricular strain: A reliable predictor of short-term outcomes in patients with anterior wall myocardial infarction without heart failure |
| title_short | Left ventricular strain: A reliable predictor of short-term outcomes in patients with anterior wall myocardial infarction without heart failure |
| title_sort | left ventricular strain a reliable predictor of short term outcomes in patients with anterior wall myocardial infarction without heart failure |
| topic | echocardiography heart failure left ventricular strain natriuretic peptides peak systolic longitudinal velocity |
| url | http://www.advbiores.net/article.asp?issn=2277-9175;year=2020;volume=9;issue=1;spage=67;epage=67;aulast=Singh |
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