Histopathological effects of doxorubicin on kidneys in rats
The aim of this study was to investigate the histolopathological effect of doxorubicin on rat kidney tissue. The drug was administrated by rats at the dose of (1, 2, 3, 4, 5) mg/kg intrapertonial every (84) hr for the three weeks and the doses of (1, 2, 3) mg/kg intrapertonial every 84 hrs for six w...
| Main Authors: | , |
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| Format: | Article |
| Language: | Arabic |
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University of Mosul, College of Veterinary Medicine
2014-06-01
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| Series: | Iraqi Journal of Veterinary Sciences |
| Subjects: | |
| Online Access: | ttp://www.vetmedmosul.org/ijvs/media/14-1-9a.pdf |
| _version_ | 1818211375785181184 |
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| author | I.A. Ali H.J. Jumaa |
| author_facet | I.A. Ali H.J. Jumaa |
| author_sort | I.A. Ali |
| collection | DOAJ |
| description | The aim of this study was to investigate the histolopathological effect of doxorubicin on rat kidney tissue. The drug was administrated by rats at the dose of (1, 2, 3, 4, 5) mg/kg intrapertonial every (84) hr for the three weeks and the doses of (1, 2, 3) mg/kg intrapertonial every 84 hrs for six weeks. The animals were scarified after 48 hr. of last injection. The study revealed congestion, thrombus, blood vessels hemorrhage, vaculation in the cells of glomerular tuft and tubular, tubuo-interstitial degeneration, tubular casts. The injury score revealed significantly increasing in the degree of injury in glomerules in the animals that received 5 mg/kg of doxorubicin for three weeks and also significantly increasing in the degree of injury in glomerules of the animals that received 3 mg/kg of doxorubicin for six weeks as compared with control animals. We concluded that the doxorubicin has histopathological effect on kidney. |
| first_indexed | 2024-12-12T05:31:30Z |
| format | Article |
| id | doaj.art-4ec59a6f19294be6b587cd09582a0d55 |
| institution | Directory Open Access Journal |
| issn | 1607-3894 1607-3894 |
| language | Arabic |
| last_indexed | 2024-12-12T05:31:30Z |
| publishDate | 2014-06-01 |
| publisher | University of Mosul, College of Veterinary Medicine |
| record_format | Article |
| series | Iraqi Journal of Veterinary Sciences |
| spelling | doaj.art-4ec59a6f19294be6b587cd09582a0d552022-12-22T00:36:17ZaraUniversity of Mosul, College of Veterinary MedicineIraqi Journal of Veterinary Sciences1607-38941607-38942014-06-0128 Arabic15562Histopathological effects of doxorubicin on kidneys in ratsI.A. Ali 0 H.J. JumaaDepartment of Biology, College of Science, University of Mosul, Mosul, IraqThe aim of this study was to investigate the histolopathological effect of doxorubicin on rat kidney tissue. The drug was administrated by rats at the dose of (1, 2, 3, 4, 5) mg/kg intrapertonial every (84) hr for the three weeks and the doses of (1, 2, 3) mg/kg intrapertonial every 84 hrs for six weeks. The animals were scarified after 48 hr. of last injection. The study revealed congestion, thrombus, blood vessels hemorrhage, vaculation in the cells of glomerular tuft and tubular, tubuo-interstitial degeneration, tubular casts. The injury score revealed significantly increasing in the degree of injury in glomerules in the animals that received 5 mg/kg of doxorubicin for three weeks and also significantly increasing in the degree of injury in glomerules of the animals that received 3 mg/kg of doxorubicin for six weeks as compared with control animals. We concluded that the doxorubicin has histopathological effect on kidney.ttp://www.vetmedmosul.org/ijvs/media/14-1-9a.pdfHistopathologicaldoxorubicinkidneys |
| spellingShingle | I.A. Ali H.J. Jumaa Histopathological effects of doxorubicin on kidneys in rats Iraqi Journal of Veterinary Sciences Histopathological doxorubicin kidneys |
| title | Histopathological effects of doxorubicin on kidneys in rats |
| title_full | Histopathological effects of doxorubicin on kidneys in rats |
| title_fullStr | Histopathological effects of doxorubicin on kidneys in rats |
| title_full_unstemmed | Histopathological effects of doxorubicin on kidneys in rats |
| title_short | Histopathological effects of doxorubicin on kidneys in rats |
| title_sort | histopathological effects of doxorubicin on kidneys in rats |
| topic | Histopathological doxorubicin kidneys |
| url | ttp://www.vetmedmosul.org/ijvs/media/14-1-9a.pdf |
| work_keys_str_mv | AT iaali histopathologicaleffectsofdoxorubicinonkidneysinrats AT hjjumaa histopathologicaleffectsofdoxorubicinonkidneysinrats |