Topography and Determinants of Magnetic Resonance Imaging (MRI)‐Visible Perivascular Spaces in a Large Memory Clinic Cohort
BackgroundMagnetic resonance imaging‐visible perivascular spaces (PVS) are related to interstitial fluid clearance pathways (including amyloid‐β) in the brain and are suggested to be a marker of cerebral small vessel disease. We investigated the role, topography, and possible implications of PVS in...
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| Format: | Article |
| Language: | English |
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Wiley
2017-09-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.117.006279 |
| _version_ | 1811329024756023296 |
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| author | Sara Shams Juha Martola Andreas Charidimou Mykol Larvie Tobias Granberg Mana Shams Maria Kristoffersen‐Wiberg Lars‐Olof Wahlund |
| author_facet | Sara Shams Juha Martola Andreas Charidimou Mykol Larvie Tobias Granberg Mana Shams Maria Kristoffersen‐Wiberg Lars‐Olof Wahlund |
| author_sort | Sara Shams |
| collection | DOAJ |
| description | BackgroundMagnetic resonance imaging‐visible perivascular spaces (PVS) are related to interstitial fluid clearance pathways (including amyloid‐β) in the brain and are suggested to be a marker of cerebral small vessel disease. We investigated the role, topography, and possible implications of PVS in cognitive impairment. Methods and ResultsA total of 1504 patients undergoing memory clinic investigation and an associated brain magnetic resonance imaging scan were included in this cross‐sectional study. Magnetic resonance images were assessed for markers of small vessel disease. Additionally, 1039 patients had cerebrospinal fluid analysis of amyloid‐β 42, total tau (T‐tau), and phosphorylated tau (P‐tau); 520 patients had apoE genotyping done. Results were analyzed with generalized linear models. A total of 289 (19%; 95% confidence interval, 17–21) had a high‐grade PVS in the centrum semiovale (CSO) and 65 (4%; 95% confidence interval: 3%–5%) in the basal ganglia (BG). Centrum semiovale– and BG‐PVS were both associated with high age (P<0.001), hypertension (P<0.001), probable cerebral amyloid angiopathy (P<0.05), moderate‐to‐severe white matter hyperintensities (P<0.001), cortical superficial siderosis (P<0.001), cerebral microbleeds (P<0.001), and PVS. centrum semiovale–PVS was separately associated with strictly lobar cerebral microbleeds (P=0.057). BG‐PVS was associated with strictly deep cerebral microbleeds (P<0.001), lacunes (P<0.001), and vascular dementia (P=0.04). BG‐PVS showed a tendency to be associated with high cerebrospinal fluid tau (B=0.002, P=0.04) in the whole cohort and in Alzheimer's disease (B=0.005; P=0.02). No other associations with cerebrospinal fluid or the apoE e4 allele was observed. ConclusionsCentrum semiovale–PVS and BG‐PVS have different underlying etiology, being associated with cerebral amyloid angiopathy and hypertensive vasculopathy, respectively, although a significant overlap between these pathologies is likely to exist. |
| first_indexed | 2024-04-13T15:36:29Z |
| format | Article |
| id | doaj.art-4ec8f15114cd405db2f8978bc3d4ff63 |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-04-13T15:36:29Z |
| publishDate | 2017-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-4ec8f15114cd405db2f8978bc3d4ff632022-12-22T02:41:16ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802017-09-016910.1161/JAHA.117.006279Topography and Determinants of Magnetic Resonance Imaging (MRI)‐Visible Perivascular Spaces in a Large Memory Clinic CohortSara Shams0Juha Martola1Andreas Charidimou2Mykol Larvie3Tobias Granberg4Mana Shams5Maria Kristoffersen‐Wiberg6Lars‐Olof Wahlund7Division of Medical Imaging and Technology, Department of Clinical Science, Intervention, and Technology, Karolinska Institutet, Stockholm, SwedenDivision of Medical Imaging and Technology, Department of Clinical Science, Intervention, and Technology, Karolinska Institutet, Stockholm, SwedenHemorrhagic Stroke Research Program, Department of Neurology, Massachusetts General Hospital Stroke Research Center, Harvard Medical School, Boston, MADepartment of Radiology, Massachusetts General Hospital, Boston, MADivision of Medical Imaging and Technology, Department of Clinical Science, Intervention, and Technology, Karolinska Institutet, Stockholm, SwedenDivision of Medical Imaging and Technology, Department of Clinical Science, Intervention, and Technology, Karolinska Institutet, Stockholm, SwedenDivision of Medical Imaging and Technology, Department of Clinical Science, Intervention, and Technology, Karolinska Institutet, Stockholm, SwedenDepartment of Neurobiology, Karolinska Institutet, Stockholm, SwedenBackgroundMagnetic resonance imaging‐visible perivascular spaces (PVS) are related to interstitial fluid clearance pathways (including amyloid‐β) in the brain and are suggested to be a marker of cerebral small vessel disease. We investigated the role, topography, and possible implications of PVS in cognitive impairment. Methods and ResultsA total of 1504 patients undergoing memory clinic investigation and an associated brain magnetic resonance imaging scan were included in this cross‐sectional study. Magnetic resonance images were assessed for markers of small vessel disease. Additionally, 1039 patients had cerebrospinal fluid analysis of amyloid‐β 42, total tau (T‐tau), and phosphorylated tau (P‐tau); 520 patients had apoE genotyping done. Results were analyzed with generalized linear models. A total of 289 (19%; 95% confidence interval, 17–21) had a high‐grade PVS in the centrum semiovale (CSO) and 65 (4%; 95% confidence interval: 3%–5%) in the basal ganglia (BG). Centrum semiovale– and BG‐PVS were both associated with high age (P<0.001), hypertension (P<0.001), probable cerebral amyloid angiopathy (P<0.05), moderate‐to‐severe white matter hyperintensities (P<0.001), cortical superficial siderosis (P<0.001), cerebral microbleeds (P<0.001), and PVS. centrum semiovale–PVS was separately associated with strictly lobar cerebral microbleeds (P=0.057). BG‐PVS was associated with strictly deep cerebral microbleeds (P<0.001), lacunes (P<0.001), and vascular dementia (P=0.04). BG‐PVS showed a tendency to be associated with high cerebrospinal fluid tau (B=0.002, P=0.04) in the whole cohort and in Alzheimer's disease (B=0.005; P=0.02). No other associations with cerebrospinal fluid or the apoE e4 allele was observed. ConclusionsCentrum semiovale–PVS and BG‐PVS have different underlying etiology, being associated with cerebral amyloid angiopathy and hypertensive vasculopathy, respectively, although a significant overlap between these pathologies is likely to exist.https://www.ahajournals.org/doi/10.1161/JAHA.117.006279cerebral microbleedcerebral small vessel diseasecognitive impairmentmagnetic resonance imaging |
| spellingShingle | Sara Shams Juha Martola Andreas Charidimou Mykol Larvie Tobias Granberg Mana Shams Maria Kristoffersen‐Wiberg Lars‐Olof Wahlund Topography and Determinants of Magnetic Resonance Imaging (MRI)‐Visible Perivascular Spaces in a Large Memory Clinic Cohort Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease cerebral microbleed cerebral small vessel disease cognitive impairment magnetic resonance imaging |
| title | Topography and Determinants of Magnetic Resonance Imaging (MRI)‐Visible Perivascular Spaces in a Large Memory Clinic Cohort |
| title_full | Topography and Determinants of Magnetic Resonance Imaging (MRI)‐Visible Perivascular Spaces in a Large Memory Clinic Cohort |
| title_fullStr | Topography and Determinants of Magnetic Resonance Imaging (MRI)‐Visible Perivascular Spaces in a Large Memory Clinic Cohort |
| title_full_unstemmed | Topography and Determinants of Magnetic Resonance Imaging (MRI)‐Visible Perivascular Spaces in a Large Memory Clinic Cohort |
| title_short | Topography and Determinants of Magnetic Resonance Imaging (MRI)‐Visible Perivascular Spaces in a Large Memory Clinic Cohort |
| title_sort | topography and determinants of magnetic resonance imaging mri visible perivascular spaces in a large memory clinic cohort |
| topic | cerebral microbleed cerebral small vessel disease cognitive impairment magnetic resonance imaging |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.117.006279 |
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