Cytotoxic Sesterterpenoids from a Sponge Hippospongia sp.
One new pentacyclic sesterterpene, hippospongide A (1), and one new scalarane sesterterpenoid, hippospongide B (2), along with six previously reported known scalarane–type sesterterpenes (3–8), were isolated from a sponge Hippospongia sp. The structures of these compounds were elucidated on the basi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2012-04-01
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| Series: | Marine Drugs |
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| Online Access: | http://www.mdpi.com/1660-3397/10/5/987/ |
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| author | Jui-Hsin Su Mei-Chin Lu Yalan Chou Yuan-Shing Ho Li-Lian Liu Yu-Chia Chang Shang-Wei Tseng |
| author_facet | Jui-Hsin Su Mei-Chin Lu Yalan Chou Yuan-Shing Ho Li-Lian Liu Yu-Chia Chang Shang-Wei Tseng |
| author_sort | Jui-Hsin Su |
| collection | DOAJ |
| description | One new pentacyclic sesterterpene, hippospongide A (1), and one new scalarane sesterterpenoid, hippospongide B (2), along with six previously reported known scalarane–type sesterterpenes (3–8), were isolated from a sponge Hippospongia sp. The structures of these compounds were elucidated on the basis of their spectroscopic data and comparison of the NMR data with those of known analogues. These metabolites are the first pentacyclic sesterterpene and scalarane-type sesterterpenes to be reported from this genus. Compounds 3–5 exhibited significant cytotoxicity against DLD-1, HCT-116, T-47D and K562 cancer cell lines. |
| first_indexed | 2024-04-14T00:18:50Z |
| format | Article |
| id | doaj.art-4ec97b80c7d64411b6f2f39ad895a4fc |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-14T00:18:50Z |
| publishDate | 2012-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-4ec97b80c7d64411b6f2f39ad895a4fc2022-12-22T02:23:02ZengMDPI AGMarine Drugs1660-33972012-04-01105987997Cytotoxic Sesterterpenoids from a Sponge Hippospongia sp.Jui-Hsin SuMei-Chin LuYalan ChouYuan-Shing HoLi-Lian LiuYu-Chia ChangShang-Wei TsengOne new pentacyclic sesterterpene, hippospongide A (1), and one new scalarane sesterterpenoid, hippospongide B (2), along with six previously reported known scalarane–type sesterterpenes (3–8), were isolated from a sponge Hippospongia sp. The structures of these compounds were elucidated on the basis of their spectroscopic data and comparison of the NMR data with those of known analogues. These metabolites are the first pentacyclic sesterterpene and scalarane-type sesterterpenes to be reported from this genus. Compounds 3–5 exhibited significant cytotoxicity against DLD-1, HCT-116, T-47D and K562 cancer cell lines.http://www.mdpi.com/1660-3397/10/5/987/sesterterpenoidscalaranespongeHippospongia |
| spellingShingle | Jui-Hsin Su Mei-Chin Lu Yalan Chou Yuan-Shing Ho Li-Lian Liu Yu-Chia Chang Shang-Wei Tseng Cytotoxic Sesterterpenoids from a Sponge Hippospongia sp. Marine Drugs sesterterpenoid scalarane sponge Hippospongia |
| title | Cytotoxic Sesterterpenoids from a Sponge Hippospongia sp. |
| title_full | Cytotoxic Sesterterpenoids from a Sponge Hippospongia sp. |
| title_fullStr | Cytotoxic Sesterterpenoids from a Sponge Hippospongia sp. |
| title_full_unstemmed | Cytotoxic Sesterterpenoids from a Sponge Hippospongia sp. |
| title_short | Cytotoxic Sesterterpenoids from a Sponge Hippospongia sp. |
| title_sort | cytotoxic sesterterpenoids from a sponge hippospongia sp |
| topic | sesterterpenoid scalarane sponge Hippospongia |
| url | http://www.mdpi.com/1660-3397/10/5/987/ |
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