The Auxiliary Role of Heparin in Bone Regeneration and its Application in Bone Substitute Materials
Bone regeneration in large segmental defects depends on the action of osteoblasts and the ingrowth of new blood vessels. Therefore, it is important to promote the release of osteogenic/angiogenic growth factors. Since the discovery of heparin, its anticoagulant, anti-inflammatory, and anticancer fun...
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| Format: | Article |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.837172/full |
| _version_ | 1818554636627345408 |
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| author | Jing Wang Lan Xiao Lan Xiao Weiqun Wang Dingmei Zhang Yaping Ma Yi Zhang Xin Wang Xin Wang Xin Wang |
| author_facet | Jing Wang Lan Xiao Lan Xiao Weiqun Wang Dingmei Zhang Yaping Ma Yi Zhang Xin Wang Xin Wang Xin Wang |
| author_sort | Jing Wang |
| collection | DOAJ |
| description | Bone regeneration in large segmental defects depends on the action of osteoblasts and the ingrowth of new blood vessels. Therefore, it is important to promote the release of osteogenic/angiogenic growth factors. Since the discovery of heparin, its anticoagulant, anti-inflammatory, and anticancer functions have been extensively studied for over a century. Although the application of heparin is widely used in the orthopedic field, its auxiliary effect on bone regeneration is yet to be unveiled. Specifically, approximately one-third of the transforming growth factor (TGF) superfamily is bound to heparin and heparan sulfate, among which TGF-β1, TGF-β2, and bone morphogenetic protein (BMP) are the most common growth factors used. In addition, heparin can also improve the delivery and retention of BMP-2 in vivo promoting the healing of large bone defects at hyper physiological doses. In blood vessel formation, heparin still plays an integral part of fracture healing by cooperating with the platelet-derived growth factor (PDGF). Importantly, since heparin binds to growth factors and release components in nanomaterials, it can significantly facilitate the controlled release and retention of growth factors [such as fibroblast growth factor (FGF), BMP, and PDGF] in vivo. Consequently, the knowledge of scaffolds or delivery systems composed of heparin and different biomaterials (including organic, inorganic, metal, and natural polymers) is vital for material-guided bone regeneration research. This study systematically reviews the structural properties and auxiliary functions of heparin, with an emphasis on bone regeneration and its application in biomaterials under physiological conditions. |
| first_indexed | 2024-12-12T09:42:35Z |
| format | Article |
| id | doaj.art-4ecb13ae7364460a9cf65ff35e2e334e |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-12-12T09:42:35Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-4ecb13ae7364460a9cf65ff35e2e334e2022-12-22T00:28:31ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-05-011010.3389/fbioe.2022.837172837172The Auxiliary Role of Heparin in Bone Regeneration and its Application in Bone Substitute MaterialsJing Wang0Lan Xiao1Lan Xiao2Weiqun Wang3Dingmei Zhang4Yaping Ma5Yi Zhang6Xin Wang7Xin Wang8Xin Wang9Department of Orthopaedic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaCentre for Biomedical Technologies, School of Mechanical, Medical and Process Engineering, Queensland University of Technology, Brisbane, AustraliaAustralia−China Centre for Tissue Engineering and Regenerative Medicine, Brisbane, AustraliaDepartment of Orthopaedic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDepartment of Orthopaedic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDepartment of Orthopaedic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDepartment of Hygiene Toxicology, School of Public Health, Zunyi Medical University, Zunyi, ChinaDepartment of Orthopaedic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaCentre for Biomedical Technologies, School of Mechanical, Medical and Process Engineering, Queensland University of Technology, Brisbane, AustraliaAustralia−China Centre for Tissue Engineering and Regenerative Medicine, Brisbane, AustraliaBone regeneration in large segmental defects depends on the action of osteoblasts and the ingrowth of new blood vessels. Therefore, it is important to promote the release of osteogenic/angiogenic growth factors. Since the discovery of heparin, its anticoagulant, anti-inflammatory, and anticancer functions have been extensively studied for over a century. Although the application of heparin is widely used in the orthopedic field, its auxiliary effect on bone regeneration is yet to be unveiled. Specifically, approximately one-third of the transforming growth factor (TGF) superfamily is bound to heparin and heparan sulfate, among which TGF-β1, TGF-β2, and bone morphogenetic protein (BMP) are the most common growth factors used. In addition, heparin can also improve the delivery and retention of BMP-2 in vivo promoting the healing of large bone defects at hyper physiological doses. In blood vessel formation, heparin still plays an integral part of fracture healing by cooperating with the platelet-derived growth factor (PDGF). Importantly, since heparin binds to growth factors and release components in nanomaterials, it can significantly facilitate the controlled release and retention of growth factors [such as fibroblast growth factor (FGF), BMP, and PDGF] in vivo. Consequently, the knowledge of scaffolds or delivery systems composed of heparin and different biomaterials (including organic, inorganic, metal, and natural polymers) is vital for material-guided bone regeneration research. This study systematically reviews the structural properties and auxiliary functions of heparin, with an emphasis on bone regeneration and its application in biomaterials under physiological conditions.https://www.frontiersin.org/articles/10.3389/fbioe.2022.837172/fullheparinnanomaterialosteogenicbone regenerationbone morphogenic protein-2bone morphogenic protein-4 |
| spellingShingle | Jing Wang Lan Xiao Lan Xiao Weiqun Wang Dingmei Zhang Yaping Ma Yi Zhang Xin Wang Xin Wang Xin Wang The Auxiliary Role of Heparin in Bone Regeneration and its Application in Bone Substitute Materials Frontiers in Bioengineering and Biotechnology heparin nanomaterial osteogenic bone regeneration bone morphogenic protein-2 bone morphogenic protein-4 |
| title | The Auxiliary Role of Heparin in Bone Regeneration and its Application in Bone Substitute Materials |
| title_full | The Auxiliary Role of Heparin in Bone Regeneration and its Application in Bone Substitute Materials |
| title_fullStr | The Auxiliary Role of Heparin in Bone Regeneration and its Application in Bone Substitute Materials |
| title_full_unstemmed | The Auxiliary Role of Heparin in Bone Regeneration and its Application in Bone Substitute Materials |
| title_short | The Auxiliary Role of Heparin in Bone Regeneration and its Application in Bone Substitute Materials |
| title_sort | auxiliary role of heparin in bone regeneration and its application in bone substitute materials |
| topic | heparin nanomaterial osteogenic bone regeneration bone morphogenic protein-2 bone morphogenic protein-4 |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.837172/full |
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