Biomarkers to Predict the Success of Treatment with the Intravitreal 0.19 mg Fluocinolone Acetonide Implant in Uveitic Macular Edema
To predict the need for additional local corticosteroids after receiving the 0.19 mg fluocinolone acetonide (FAc) implant in patients with macular edema secondary to non-infectious uveitis previously treated with local peribulbar corticosteroids. The number of corticosteroids required prior FAc, vis...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-03-01
|
| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/14/4/688 |
| _version_ | 1797434286722252800 |
|---|---|
| author | Lucy Joanne Kessler Grzegorz Łabuz Gerd U. Auffarth Ramin Khoramnia |
| author_facet | Lucy Joanne Kessler Grzegorz Łabuz Gerd U. Auffarth Ramin Khoramnia |
| author_sort | Lucy Joanne Kessler |
| collection | DOAJ |
| description | To predict the need for additional local corticosteroids after receiving the 0.19 mg fluocinolone acetonide (FAc) implant in patients with macular edema secondary to non-infectious uveitis previously treated with local peribulbar corticosteroids. The number of corticosteroids required prior FAc, visual acuity, central retinal thickness, ellipsoid zone reflectivity ratio (EZR), and choroidal vascularity index (CVI) were compared between patients who did and did not require additional corticosteroids after FAc implantation. Pearson’s correlation coefficient (R) between putative predictors and the number of adjunctive corticosteroids after FAc implantation were measured; significant candidates were included in a generalized regression model. Patients who required additional corticosteroids after FAc had higher CVI and central retinal thickness as well as worse EZR at subsequent visits (<i>p</i> < 0.05). The number of corticosteroids required prior to FAc implantation (R: 0.49), CVI change from baseline to 6 months (R: −0.41), and central retinal thickness at baseline (R: −0.36) correlated to the number of additional corticosteroids (all <i>p</i> < 0.05). A higher number of corticosteroids per year before FAc implantation was predictive for an increase in corticosteroids required after FAc (odds ratio = 2.65), while a decrease in CVI from baseline to 6 months was inversely correlated (odds ratio = 0.82). Our results suggest that the more corticosteroids prior to FAc and the greater the short-term CVI reducing effect, the less is the chance to get additional corticosteroids after FAc. |
| first_indexed | 2024-03-09T10:31:02Z |
| format | Article |
| id | doaj.art-4ecbb422f32e4dccb32ed480afda45ca |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T10:31:02Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-4ecbb422f32e4dccb32ed480afda45ca2023-12-01T21:18:20ZengMDPI AGPharmaceutics1999-49232022-03-0114468810.3390/pharmaceutics14040688Biomarkers to Predict the Success of Treatment with the Intravitreal 0.19 mg Fluocinolone Acetonide Implant in Uveitic Macular EdemaLucy Joanne Kessler0Grzegorz Łabuz1Gerd U. Auffarth2Ramin Khoramnia3Department of Ophthalmology, University Hospital Heidelberg, 69120 Heidelberg, GermanyDepartment of Ophthalmology, University Hospital Heidelberg, 69120 Heidelberg, GermanyDepartment of Ophthalmology, University Hospital Heidelberg, 69120 Heidelberg, GermanyDepartment of Ophthalmology, University Hospital Heidelberg, 69120 Heidelberg, GermanyTo predict the need for additional local corticosteroids after receiving the 0.19 mg fluocinolone acetonide (FAc) implant in patients with macular edema secondary to non-infectious uveitis previously treated with local peribulbar corticosteroids. The number of corticosteroids required prior FAc, visual acuity, central retinal thickness, ellipsoid zone reflectivity ratio (EZR), and choroidal vascularity index (CVI) were compared between patients who did and did not require additional corticosteroids after FAc implantation. Pearson’s correlation coefficient (R) between putative predictors and the number of adjunctive corticosteroids after FAc implantation were measured; significant candidates were included in a generalized regression model. Patients who required additional corticosteroids after FAc had higher CVI and central retinal thickness as well as worse EZR at subsequent visits (<i>p</i> < 0.05). The number of corticosteroids required prior to FAc implantation (R: 0.49), CVI change from baseline to 6 months (R: −0.41), and central retinal thickness at baseline (R: −0.36) correlated to the number of additional corticosteroids (all <i>p</i> < 0.05). A higher number of corticosteroids per year before FAc implantation was predictive for an increase in corticosteroids required after FAc (odds ratio = 2.65), while a decrease in CVI from baseline to 6 months was inversely correlated (odds ratio = 0.82). Our results suggest that the more corticosteroids prior to FAc and the greater the short-term CVI reducing effect, the less is the chance to get additional corticosteroids after FAc.https://www.mdpi.com/1999-4923/14/4/688uveitisfluocinolone acetonidemacular edemaOCT biomarkerschoroidal vascularity index |
| spellingShingle | Lucy Joanne Kessler Grzegorz Łabuz Gerd U. Auffarth Ramin Khoramnia Biomarkers to Predict the Success of Treatment with the Intravitreal 0.19 mg Fluocinolone Acetonide Implant in Uveitic Macular Edema Pharmaceutics uveitis fluocinolone acetonide macular edema OCT biomarkers choroidal vascularity index |
| title | Biomarkers to Predict the Success of Treatment with the Intravitreal 0.19 mg Fluocinolone Acetonide Implant in Uveitic Macular Edema |
| title_full | Biomarkers to Predict the Success of Treatment with the Intravitreal 0.19 mg Fluocinolone Acetonide Implant in Uveitic Macular Edema |
| title_fullStr | Biomarkers to Predict the Success of Treatment with the Intravitreal 0.19 mg Fluocinolone Acetonide Implant in Uveitic Macular Edema |
| title_full_unstemmed | Biomarkers to Predict the Success of Treatment with the Intravitreal 0.19 mg Fluocinolone Acetonide Implant in Uveitic Macular Edema |
| title_short | Biomarkers to Predict the Success of Treatment with the Intravitreal 0.19 mg Fluocinolone Acetonide Implant in Uveitic Macular Edema |
| title_sort | biomarkers to predict the success of treatment with the intravitreal 0 19 mg fluocinolone acetonide implant in uveitic macular edema |
| topic | uveitis fluocinolone acetonide macular edema OCT biomarkers choroidal vascularity index |
| url | https://www.mdpi.com/1999-4923/14/4/688 |
| work_keys_str_mv | AT lucyjoannekessler biomarkerstopredictthesuccessoftreatmentwiththeintravitreal019mgfluocinoloneacetonideimplantinuveiticmacularedema AT grzegorzłabuz biomarkerstopredictthesuccessoftreatmentwiththeintravitreal019mgfluocinoloneacetonideimplantinuveiticmacularedema AT gerduauffarth biomarkerstopredictthesuccessoftreatmentwiththeintravitreal019mgfluocinoloneacetonideimplantinuveiticmacularedema AT raminkhoramnia biomarkerstopredictthesuccessoftreatmentwiththeintravitreal019mgfluocinoloneacetonideimplantinuveiticmacularedema |