Update on the olfactory receptor (<it>OR</it>) gene superfamily
<p>Abstract</p> <p>The olfactory receptor gene (<it>OR</it>) superfamily is the largest in the human genome. The superfamily contains 390 putatively functional genes and 465 pseudogenes arranged into 18 gene families and 300 subfamilies. Even members within the same sub...
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| Format: | Article |
| Language: | English |
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BMC
2008-09-01
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| Series: | Human Genomics |
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| Online Access: | http://www.humgenomics.com/content/3/1/87 |
| _version_ | 1811264142158331904 |
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| author | Olender Tsviya Lancet Doron Nebert Daniel W |
| author_facet | Olender Tsviya Lancet Doron Nebert Daniel W |
| author_sort | Olender Tsviya |
| collection | DOAJ |
| description | <p>Abstract</p> <p>The olfactory receptor gene (<it>OR</it>) superfamily is the largest in the human genome. The superfamily contains 390 putatively functional genes and 465 pseudogenes arranged into 18 gene families and 300 subfamilies. Even members within the same subfamily are often located on different chromosomes. <it>OR </it>genes are located on all autosomes except chromosome 20, plus the X chromosome but not the Y chromosome. The gene:pseudogene ratio is lowest in human, higher in chimpanzee and highest in rat and mouse -- most likely reflecting the greater need of olfaction for survival in the rodent than in the human. The <it>OR </it>genes undergo allelic exclusion, each sensory neurone expressing usually only one odourant receptor allele; the mechanism by which this phenomenon is regulated is not yet understood. The nomenclature system (based on evolutionary divergence of genes into families and subfamilies of the <it>OR </it>gene superfamily) has been designed similarly to that originally used for the <it>CYP </it>gene superfamily.</p> |
| first_indexed | 2024-04-12T19:57:32Z |
| format | Article |
| id | doaj.art-4ecd8232926b41faa1eec4631c9f32d3 |
| institution | Directory Open Access Journal |
| issn | 1479-7364 |
| language | English |
| last_indexed | 2024-04-12T19:57:32Z |
| publishDate | 2008-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Human Genomics |
| spelling | doaj.art-4ecd8232926b41faa1eec4631c9f32d32022-12-22T03:18:37ZengBMCHuman Genomics1479-73642008-09-0131879710.1186/1479-7364-3-1-87Update on the olfactory receptor (<it>OR</it>) gene superfamilyOlender TsviyaLancet DoronNebert Daniel W<p>Abstract</p> <p>The olfactory receptor gene (<it>OR</it>) superfamily is the largest in the human genome. The superfamily contains 390 putatively functional genes and 465 pseudogenes arranged into 18 gene families and 300 subfamilies. Even members within the same subfamily are often located on different chromosomes. <it>OR </it>genes are located on all autosomes except chromosome 20, plus the X chromosome but not the Y chromosome. The gene:pseudogene ratio is lowest in human, higher in chimpanzee and highest in rat and mouse -- most likely reflecting the greater need of olfaction for survival in the rodent than in the human. The <it>OR </it>genes undergo allelic exclusion, each sensory neurone expressing usually only one odourant receptor allele; the mechanism by which this phenomenon is regulated is not yet understood. The nomenclature system (based on evolutionary divergence of genes into families and subfamilies of the <it>OR </it>gene superfamily) has been designed similarly to that originally used for the <it>CYP </it>gene superfamily.</p>http://www.humgenomics.com/content/3/1/87classification of gene families and subfamiliesOR gene superfamilyCYP gene superfamilynasal olfactory neuroneolfactionolfactory receptor gene superfamilyallelic exclusionopossum genomeplatypus genome |
| spellingShingle | Olender Tsviya Lancet Doron Nebert Daniel W Update on the olfactory receptor (<it>OR</it>) gene superfamily Human Genomics classification of gene families and subfamilies OR gene superfamily CYP gene superfamily nasal olfactory neurone olfaction olfactory receptor gene superfamily allelic exclusion opossum genome platypus genome |
| title | Update on the olfactory receptor (<it>OR</it>) gene superfamily |
| title_full | Update on the olfactory receptor (<it>OR</it>) gene superfamily |
| title_fullStr | Update on the olfactory receptor (<it>OR</it>) gene superfamily |
| title_full_unstemmed | Update on the olfactory receptor (<it>OR</it>) gene superfamily |
| title_short | Update on the olfactory receptor (<it>OR</it>) gene superfamily |
| title_sort | update on the olfactory receptor it or it gene superfamily |
| topic | classification of gene families and subfamilies OR gene superfamily CYP gene superfamily nasal olfactory neurone olfaction olfactory receptor gene superfamily allelic exclusion opossum genome platypus genome |
| url | http://www.humgenomics.com/content/3/1/87 |
| work_keys_str_mv | AT olendertsviya updateontheolfactoryreceptoritoritgenesuperfamily AT lancetdoron updateontheolfactoryreceptoritoritgenesuperfamily AT nebertdanielw updateontheolfactoryreceptoritoritgenesuperfamily |