Hydroxylases involved in terpenoid biosynthesis: a review
Abstract Terpenoids are pervasive in nature and display an immense structural diversity. As the largest category of plant secondary metabolites, terpenoids have important socioeconomic value in the fields of pharmaceuticals, spices, and food manufacturing. The biosynthesis of terpenoid skeletons has...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2023-07-01
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| Series: | Bioresources and Bioprocessing |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40643-023-00656-1 |
| _version_ | 1797779048873590784 |
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| author | Zihan Zhang Qing-Yang Wu Yue Ge Zheng-Yu Huang Ran Hong Aitao Li Jian-He Xu Hui-Lei Yu |
| author_facet | Zihan Zhang Qing-Yang Wu Yue Ge Zheng-Yu Huang Ran Hong Aitao Li Jian-He Xu Hui-Lei Yu |
| author_sort | Zihan Zhang |
| collection | DOAJ |
| description | Abstract Terpenoids are pervasive in nature and display an immense structural diversity. As the largest category of plant secondary metabolites, terpenoids have important socioeconomic value in the fields of pharmaceuticals, spices, and food manufacturing. The biosynthesis of terpenoid skeletons has made great progress, but the subsequent modifications of the terpenoid framework are poorly understood, especially for the functionalization of inert carbon skeleton usually catalyzed by hydroxylases. Hydroxylase is a class of enzymes that plays an important role in the modification of terpenoid backbone. This review article outlines the research progress in the identification, molecular modification, and functional expression of this class of enzymes in the past decade, which are profitable for the discovery, engineering, and application of more hydroxylases involved in the plant secondary metabolism. Graphical Abstract |
| first_indexed | 2024-03-12T23:26:06Z |
| format | Article |
| id | doaj.art-4ed16f1019074636afb00f9051e09ba5 |
| institution | Directory Open Access Journal |
| issn | 2197-4365 |
| language | English |
| last_indexed | 2024-03-12T23:26:06Z |
| publishDate | 2023-07-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Bioresources and Bioprocessing |
| spelling | doaj.art-4ed16f1019074636afb00f9051e09ba52023-07-16T11:08:05ZengSpringerOpenBioresources and Bioprocessing2197-43652023-07-0110113210.1186/s40643-023-00656-1Hydroxylases involved in terpenoid biosynthesis: a reviewZihan Zhang0Qing-Yang Wu1Yue Ge2Zheng-Yu Huang3Ran Hong4Aitao Li5Jian-He Xu6Hui-Lei Yu7State Key Laboratory of Bioreactor Engineering, Shanghai Collaborative Innovation Centre for Biomanufacturing, East China University of Science and TechnologyState Key Laboratory of Bioreactor Engineering, Shanghai Collaborative Innovation Centre for Biomanufacturing, East China University of Science and TechnologyState Key Laboratory of Bioreactor Engineering, Shanghai Collaborative Innovation Centre for Biomanufacturing, East China University of Science and TechnologyState Key Laboratory of Bioreactor Engineering, Shanghai Collaborative Innovation Centre for Biomanufacturing, East China University of Science and TechnologyCAS Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of SciencesSchool of Life Sciences, State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei UniversityState Key Laboratory of Bioreactor Engineering, Shanghai Collaborative Innovation Centre for Biomanufacturing, East China University of Science and TechnologyState Key Laboratory of Bioreactor Engineering, Shanghai Collaborative Innovation Centre for Biomanufacturing, East China University of Science and TechnologyAbstract Terpenoids are pervasive in nature and display an immense structural diversity. As the largest category of plant secondary metabolites, terpenoids have important socioeconomic value in the fields of pharmaceuticals, spices, and food manufacturing. The biosynthesis of terpenoid skeletons has made great progress, but the subsequent modifications of the terpenoid framework are poorly understood, especially for the functionalization of inert carbon skeleton usually catalyzed by hydroxylases. Hydroxylase is a class of enzymes that plays an important role in the modification of terpenoid backbone. This review article outlines the research progress in the identification, molecular modification, and functional expression of this class of enzymes in the past decade, which are profitable for the discovery, engineering, and application of more hydroxylases involved in the plant secondary metabolism. Graphical Abstracthttps://doi.org/10.1186/s40643-023-00656-1BiooxidationCytochrome P450 monooxygenaseHydroxylaseNatural productsTerpenoids |
| spellingShingle | Zihan Zhang Qing-Yang Wu Yue Ge Zheng-Yu Huang Ran Hong Aitao Li Jian-He Xu Hui-Lei Yu Hydroxylases involved in terpenoid biosynthesis: a review Bioresources and Bioprocessing Biooxidation Cytochrome P450 monooxygenase Hydroxylase Natural products Terpenoids |
| title | Hydroxylases involved in terpenoid biosynthesis: a review |
| title_full | Hydroxylases involved in terpenoid biosynthesis: a review |
| title_fullStr | Hydroxylases involved in terpenoid biosynthesis: a review |
| title_full_unstemmed | Hydroxylases involved in terpenoid biosynthesis: a review |
| title_short | Hydroxylases involved in terpenoid biosynthesis: a review |
| title_sort | hydroxylases involved in terpenoid biosynthesis a review |
| topic | Biooxidation Cytochrome P450 monooxygenase Hydroxylase Natural products Terpenoids |
| url | https://doi.org/10.1186/s40643-023-00656-1 |
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