Percutaneous bone adhesive application for Jones fracture “at-risk” of nonunion or delayed union: a hypothesis
Abstract Background Bone adhesives have been on the forefront of orthopedic surgery research for decades due to the potential benefit they may have in fracture management. Current publications and research being conducted on bone adhesive could be applied to our current hypothesis for the benefit of...
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| Format: | Article |
| Language: | English |
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BMC
2022-12-01
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| Series: | Patient Safety in Surgery |
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| Online Access: | https://doi.org/10.1186/s13037-022-00348-3 |
| _version_ | 1811315153791090688 |
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| author | Niaz Ahankoob Vincent P. Stahel |
| author_facet | Niaz Ahankoob Vincent P. Stahel |
| author_sort | Niaz Ahankoob |
| collection | DOAJ |
| description | Abstract Background Bone adhesives have been on the forefront of orthopedic surgery research for decades due to the potential benefit they may have in fracture management. Current publications and research being conducted on bone adhesive could be applied to our current hypothesis for the benefit of a novel minimally invasive treatment option for a select cohort of fractures, Jones fractures. The select fracture’s gold standard of treatment would be nonoperative, but with risk of complications including nonunion and delayed union. Presentation of hypothesis We hypothesize that percutaneous application of bone adhesive will provide an additional treatment option for fracture patterns that do not require operative fixation, but would benefit from additional stability. The primary outcome measures would be (1) duration of time required for bony consolidation (defined as 3 of 4 bridging cortices) and (2) duration of absenteeism (inability to work), and pain levels within the first week after the procedure. Secondary outcome measures would be the incidence of nonunion or delayed union. We hypothesize that the select bone adhesive would accelerate bony consolidation, decrease absenteeism, decrease pain levels within the first week after procedure, and decrease the incidence of delayed union and/or nonunion. Testing of hypothesis We propose a prospective multicenter, randomized, and open label trial clinical trial to test the bone adhesive via percutaneous injection into acute non-displaced or minimally displaced Jones fractures. Implications of hypothesis Bone adhesives are a new frontier in treatment of fractures, currently in laboratory and animal testing phases. The appropriate bone adhesive formula has not been approved for clinical trial use, but the implications of the bone adhesive may go beyond decreased complications and ease of stabilizing a select cohort of closed fractures. With the injectable compound illustrated (Fig. 1), the adhesive could be applied percutaneously in hopes of achieving improved outcomes compared to non-operative treatment. The overall goal of the clinical trial is to provide patients a safe treatment option for improved bone union rates of nonoperative fractures compared to the current gold standard management of the same fracture with earlier pain control, early bony consolidation and lower risk of delayed union/nonunion. The ideal patient population for use of a percutaneous bone adhesive in future studies would be for those with multiple medical comorbidities for whom surgical risks outweigh the benefits, in addition to patients at high risk for nonunion based on fracture pattern or systemic biology. |
| first_indexed | 2024-04-13T11:25:07Z |
| format | Article |
| id | doaj.art-4ed293404f15471c9804cee0e535d0a6 |
| institution | Directory Open Access Journal |
| issn | 1754-9493 |
| language | English |
| last_indexed | 2024-04-13T11:25:07Z |
| publishDate | 2022-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Patient Safety in Surgery |
| spelling | doaj.art-4ed293404f15471c9804cee0e535d0a62022-12-22T02:48:42ZengBMCPatient Safety in Surgery1754-94932022-12-011611610.1186/s13037-022-00348-3Percutaneous bone adhesive application for Jones fracture “at-risk” of nonunion or delayed union: a hypothesisNiaz Ahankoob0Vincent P. Stahel1Rocky Vista University, College of Osteopathic MedicineUniversity of Colorado BoulderAbstract Background Bone adhesives have been on the forefront of orthopedic surgery research for decades due to the potential benefit they may have in fracture management. Current publications and research being conducted on bone adhesive could be applied to our current hypothesis for the benefit of a novel minimally invasive treatment option for a select cohort of fractures, Jones fractures. The select fracture’s gold standard of treatment would be nonoperative, but with risk of complications including nonunion and delayed union. Presentation of hypothesis We hypothesize that percutaneous application of bone adhesive will provide an additional treatment option for fracture patterns that do not require operative fixation, but would benefit from additional stability. The primary outcome measures would be (1) duration of time required for bony consolidation (defined as 3 of 4 bridging cortices) and (2) duration of absenteeism (inability to work), and pain levels within the first week after the procedure. Secondary outcome measures would be the incidence of nonunion or delayed union. We hypothesize that the select bone adhesive would accelerate bony consolidation, decrease absenteeism, decrease pain levels within the first week after procedure, and decrease the incidence of delayed union and/or nonunion. Testing of hypothesis We propose a prospective multicenter, randomized, and open label trial clinical trial to test the bone adhesive via percutaneous injection into acute non-displaced or minimally displaced Jones fractures. Implications of hypothesis Bone adhesives are a new frontier in treatment of fractures, currently in laboratory and animal testing phases. The appropriate bone adhesive formula has not been approved for clinical trial use, but the implications of the bone adhesive may go beyond decreased complications and ease of stabilizing a select cohort of closed fractures. With the injectable compound illustrated (Fig. 1), the adhesive could be applied percutaneously in hopes of achieving improved outcomes compared to non-operative treatment. The overall goal of the clinical trial is to provide patients a safe treatment option for improved bone union rates of nonoperative fractures compared to the current gold standard management of the same fracture with earlier pain control, early bony consolidation and lower risk of delayed union/nonunion. The ideal patient population for use of a percutaneous bone adhesive in future studies would be for those with multiple medical comorbidities for whom surgical risks outweigh the benefits, in addition to patients at high risk for nonunion based on fracture pattern or systemic biology.https://doi.org/10.1186/s13037-022-00348-3Bone adhesiveClosed fractureFracture displacementPatient safetyNonunion |
| spellingShingle | Niaz Ahankoob Vincent P. Stahel Percutaneous bone adhesive application for Jones fracture “at-risk” of nonunion or delayed union: a hypothesis Patient Safety in Surgery Bone adhesive Closed fracture Fracture displacement Patient safety Nonunion |
| title | Percutaneous bone adhesive application for Jones fracture “at-risk” of nonunion or delayed union: a hypothesis |
| title_full | Percutaneous bone adhesive application for Jones fracture “at-risk” of nonunion or delayed union: a hypothesis |
| title_fullStr | Percutaneous bone adhesive application for Jones fracture “at-risk” of nonunion or delayed union: a hypothesis |
| title_full_unstemmed | Percutaneous bone adhesive application for Jones fracture “at-risk” of nonunion or delayed union: a hypothesis |
| title_short | Percutaneous bone adhesive application for Jones fracture “at-risk” of nonunion or delayed union: a hypothesis |
| title_sort | percutaneous bone adhesive application for jones fracture at risk of nonunion or delayed union a hypothesis |
| topic | Bone adhesive Closed fracture Fracture displacement Patient safety Nonunion |
| url | https://doi.org/10.1186/s13037-022-00348-3 |
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