Low-Level Endothelial TRAIL-Receptor Expression Obstructs the CNS-Delivery of Angiopep-2 Functionalised TRAIL-Receptor Agonists for the Treatment of Glioblastoma

Low-Level Endothelial TRAIL-Receptor Expression Obstructs the CNS-Delivery of Angiopep-2 Functionalised TRAIL-Receptor Agonists for the Treatment of Glioblastoma

Glioblastoma (GBM) is the most malignant and aggressive form of glioma and is associated with a poor survival rate. Latest generation Tumour Necrosis Factor Related Apoptosis-Inducing Ligand (TRAIL)-based therapeutics potently induce apoptosis in cancer cells, including GBM cells, by binding to deat...

Deskribapen osoa

Xehetasun bibliografikoak
Egile Nagusiak:	Nivetha Krishna Moorthy, Oliver Seifert, Stephan Eisler, Sara Weirich, Roland E. Kontermann, Markus Rehm, Gavin Fullstone
Formatua:	Artikulua
Hizkuntza:	English
Argitaratua:	MDPI AG 2021-12-01
Saila:	Molecules
Gaiak:	glioblastoma TRAIL angiopep-2 CNS delivery receptor-mediated transcytosis blood–brain barrier
Sarrera elektronikoa:	https://www.mdpi.com/1420-3049/26/24/7582

Antzeko izenburuak

Revealing Angiopep-2/LRP1 Molecular Interaction for Optimal Delivery to Glioblastoma (GBM)
nork: Angela Costagliola di Polidoro, et al.
Argitaratua: (2022-10-01)

Specific anti‐glioma targeted‐delivery strategy of engineered small extracellular vesicles dual‐functionalised by Angiopep‐2 and TAT peptides
nork: Zhanchi Zhu, et al.
Argitaratua: (2022-08-01)

An Angiopep2-PAPTP Construct Overcomes the Blood-Brain Barrier. New Perspectives against Brain Tumors
nork: Sofia Parrasia, et al.
Argitaratua: (2021-02-01)

Development of Angiopep-2 targeted dendrimer-based nanotheranostic system for enhanced temozolomide delivery to glioblastoma multiforme
nork: Ashish Kumar Parashar, et al.
Argitaratua: (2025-02-01)

Urban trails : a preliminary list of trails and sources/
nork: 409605 Goodey, Brian
Argitaratua: (1974)

Angiopep-2-conjugated poly(ethylene glycol)-co-poly(ε-caprolactone) polymersomes for dual-targeting drug delivery to glioma in rats
nork: Lu F, et al.
Argitaratua: (2017-03-01)

Trailing TRAIL Resistance: Novel Targets for TRAIL sensitization in Cancer cells
nork: RACHANA eTRIVEDI, et al.
Argitaratua: (2015-04-01)

Planning for urban trails/
nork: 8697 American Society of Planning Officials, et al.
Argitaratua: (1969)

Boron-peptide conjugates with angiopep-2 for boron neutron capture therapy
nork: Jing Xiang, et al.
Argitaratua: (2023-06-01)

Alternative functions for TRAIL receptors in eosinophils and neutrophils
nork: I Daigle
Argitaratua: (2001-05-01)

Assessment of concentrations of sTRAIL ligand and its receptors sTRAIL-R1 and sTRAIL-R2 – markers monitoring the course of the extrinsic pathway of apoptosis induction: potential application in ovarian cancer diagnostics
nork: Aleksandra Mielczarek-Palacz, et al.
Argitaratua: (2015-11-01)

“Wild” Generosity: The Role of Trail Angels in Shaping Community on America’s Long-Distance Hiking Trails
nork: Kristi McLeod
Argitaratua: (2024-07-01)

TRAIL and curcumin codelivery nanoparticles enhance TRAIL-induced apoptosis through upregulation of death receptors
nork: Xi Yang, et al.
Argitaratua: (2017-01-01)

OBSERVATIONAL TRAILS IN LIPIDOLOGY
nork: S. A. Shalnova
Argitaratua: (2016-01-01)

Targeting Brain Drug Delivery with Macromolecules Through Receptor-Mediated Transcytosis
nork: Yuanke Li, et al.
Argitaratua: (2025-01-01)

Long-lived meteor trails
nork: Mikhalev A.V., et al.
Argitaratua: (2019-09-01)

Recombinant expressing angiopep-2 fused anti-VEGF single chain Fab (scFab) could cross blood–brain barrier and target glioma
nork: Xuemei Ji, et al.
Argitaratua: (2019-10-01)

The Importance of Regional Trails for the Viability of the Brazilian Long Trails Network
nork: Michel Tadeu R. N. de Omena, et al.
Argitaratua: (2020-10-01)

Multiple Interactions Between Cancer Cells and the Tumor Microenvironment Modulate TRAIL Signaling: Implications for TRAIL Receptor Targeted Therapy
nork: Margot de Looff, et al.
Argitaratua: (2019-07-01)

Regulation of Cancer Metastasis by TRAIL/Death Receptor Signaling
nork: You-Take Oh, et al.
Argitaratua: (2021-03-01)

Physical impact indicators for mountain trails at Gunung Tahan Trail, Malaysia
nork: Yaakob, Sam Shor Nahar
Argitaratua: (2019)

Improved Differential and Linear Trail Bounds for ASCON
nork: Solane El Hirch, et al.
Argitaratua: (2022-12-01)

Big Five Trails: A Critical Review
nork: Najm Abood Najm
Argitaratua: (2019-08-01)

Enacting Phenomenological Gestalts in Ultra-Trail Running: An Inductive Analysis of Trail Runners’ Courses of Experience
nork: Nadège Rochat, et al.
Argitaratua: (2018-10-01)

SELECTED NATURE TRAILS OF PENANG ISLAND
nork: Malaysian Nature Society, issuing body
Argitaratua: (1999)

Traals for the twenty-first century : planning, design, and managemant manual for multi use-trails /
nork: Ryan, Karen-Lee
Argitaratua: (1993)

New techniques for trail bounds and application to differential trails in Keccak
nork: Silvia Mella, et al.
Argitaratua: (2017-03-01)

The TRAIL in the Treatment of Human Cancer: An Update on Clinical Trials
nork: Martin Snajdauf, et al.
Argitaratua: (2021-03-01)

Reflections about the geologic trails in Slovenia
nork: Rajko Pavlovec
Argitaratua: (2002-12-01)

Turn TRAIL Into Better Anticancer Therapeutic Through TRAIL Fusion Proteins
nork: Yan Wang, et al.
Argitaratua: (2025-01-01)

Design and Development of a Trailed Type Transplanter for Oil Palm Seedling
nork: El Pebrian, Darius
Argitaratua: (2002)

STEM Trails: Enhancing STEM Education through Math Trails with Digital Technology
nork: Adi Nur Cahyono, et al.
Argitaratua: (2024-05-01)

Mathematics Trails: Shallow and Deep Gamification
nork: Iwan Gurjanow, et al.
Argitaratua: (2019-09-01)

Behind the Adaptive and Resistance Mechanisms of Cancer Stem Cells to TRAIL
nork: Adriana G. Quiroz-Reyes, et al.
Argitaratua: (2021-07-01)

Enhancing radiation response by a second-generation TRAIL receptor agonist using a new in vitro organoid model system
nork: Shuraila F. Zerp, et al.
Argitaratua: (2020-09-01)

Evaluation and Optimization of Restorative Environmental Perception of Treetop Trails: The Case of the Mountains-to-Sea Trail, Xiamen, China
nork: Honglin Wu, et al.
Argitaratua: (2023-07-01)

The Oregan trail /
nork: 350759 Parkman, Francis
Argitaratua: (1931)

Main Characteristics of Trails on Yarmouk Forest Reserve, A Quantitative Approach to Trails Assessment
nork: Loay Alzriqat, Sana’a Odat and Ismaiel Abuamoud
Argitaratua: (2022-09-01)

Endogenous TRAIL-R4 critically impacts apoptotic and non-apoptotic TRAIL-induced signaling in cancer cells
nork: Anna-Christina Rambow, et al.
Argitaratua: (2022-09-01)

Urban walks and town trails : origins, principles and sources/
nork: 410008 Goodney, Brian
Argitaratua: (1974)