Low-Level Endothelial TRAIL-Receptor Expression Obstructs the CNS-Delivery of Angiopep-2 Functionalised TRAIL-Receptor Agonists for the Treatment of Glioblastoma

Low-Level Endothelial TRAIL-Receptor Expression Obstructs the CNS-Delivery of Angiopep-2 Functionalised TRAIL-Receptor Agonists for the Treatment of Glioblastoma

Glioblastoma (GBM) is the most malignant and aggressive form of glioma and is associated with a poor survival rate. Latest generation Tumour Necrosis Factor Related Apoptosis-Inducing Ligand (TRAIL)-based therapeutics potently induce apoptosis in cancer cells, including GBM cells, by binding to deat...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид:	Nivetha Krishna Moorthy, Oliver Seifert, Stephan Eisler, Sara Weirich, Roland E. Kontermann, Markus Rehm, Gavin Fullstone
Формат:	Өгүүллэг
Хэл сонгох:	English
Хэвлэсэн:	MDPI AG 2021-12-01
Цуврал:	Molecules
Нөхцлүүд:	glioblastoma TRAIL angiopep-2 CNS delivery receptor-mediated transcytosis blood–brain barrier
Онлайн хандалт:	https://www.mdpi.com/1420-3049/26/24/7582

Ижил төстэй зүйлс

Revealing Angiopep-2/LRP1 Molecular Interaction for Optimal Delivery to Glioblastoma (GBM)
-н: Angela Costagliola di Polidoro, зэрэг
Хэвлэсэн: (2022-10-01)

Specific anti‐glioma targeted‐delivery strategy of engineered small extracellular vesicles dual‐functionalised by Angiopep‐2 and TAT peptides
-н: Zhanchi Zhu, зэрэг
Хэвлэсэн: (2022-08-01)

An Angiopep2-PAPTP Construct Overcomes the Blood-Brain Barrier. New Perspectives against Brain Tumors
-н: Sofia Parrasia, зэрэг
Хэвлэсэн: (2021-02-01)

Development of Angiopep-2 targeted dendrimer-based nanotheranostic system for enhanced temozolomide delivery to glioblastoma multiforme
-н: Ashish Kumar Parashar, зэрэг
Хэвлэсэн: (2025-02-01)

Urban trails : a preliminary list of trails and sources/
-н: 409605 Goodey, Brian
Хэвлэсэн: (1974)

Angiopep-2-conjugated poly(ethylene glycol)-co-poly(ε-caprolactone) polymersomes for dual-targeting drug delivery to glioma in rats
-н: Lu F, зэрэг
Хэвлэсэн: (2017-03-01)

Trailing TRAIL Resistance: Novel Targets for TRAIL sensitization in Cancer cells
-н: RACHANA eTRIVEDI, зэрэг
Хэвлэсэн: (2015-04-01)

Planning for urban trails/
-н: 8697 American Society of Planning Officials, зэрэг
Хэвлэсэн: (1969)

Boron-peptide conjugates with angiopep-2 for boron neutron capture therapy
-н: Jing Xiang, зэрэг
Хэвлэсэн: (2023-06-01)

Alternative functions for TRAIL receptors in eosinophils and neutrophils
-н: I Daigle
Хэвлэсэн: (2001-05-01)

Assessment of concentrations of sTRAIL ligand and its receptors sTRAIL-R1 and sTRAIL-R2 – markers monitoring the course of the extrinsic pathway of apoptosis induction: potential application in ovarian cancer diagnostics
-н: Aleksandra Mielczarek-Palacz, зэрэг
Хэвлэсэн: (2015-11-01)

“Wild” Generosity: The Role of Trail Angels in Shaping Community on America’s Long-Distance Hiking Trails
-н: Kristi McLeod
Хэвлэсэн: (2024-07-01)

TRAIL and curcumin codelivery nanoparticles enhance TRAIL-induced apoptosis through upregulation of death receptors
-н: Xi Yang, зэрэг
Хэвлэсэн: (2017-01-01)

OBSERVATIONAL TRAILS IN LIPIDOLOGY
-н: S. A. Shalnova
Хэвлэсэн: (2016-01-01)

Targeting Brain Drug Delivery with Macromolecules Through Receptor-Mediated Transcytosis
-н: Yuanke Li, зэрэг
Хэвлэсэн: (2025-01-01)

Long-lived meteor trails
-н: Mikhalev A.V., зэрэг
Хэвлэсэн: (2019-09-01)

Recombinant expressing angiopep-2 fused anti-VEGF single chain Fab (scFab) could cross blood–brain barrier and target glioma
-н: Xuemei Ji, зэрэг
Хэвлэсэн: (2019-10-01)

The Importance of Regional Trails for the Viability of the Brazilian Long Trails Network
-н: Michel Tadeu R. N. de Omena, зэрэг
Хэвлэсэн: (2020-10-01)

Multiple Interactions Between Cancer Cells and the Tumor Microenvironment Modulate TRAIL Signaling: Implications for TRAIL Receptor Targeted Therapy
-н: Margot de Looff, зэрэг
Хэвлэсэн: (2019-07-01)

Regulation of Cancer Metastasis by TRAIL/Death Receptor Signaling
-н: You-Take Oh, зэрэг
Хэвлэсэн: (2021-03-01)

Physical impact indicators for mountain trails at Gunung Tahan Trail, Malaysia
-н: Yaakob, Sam Shor Nahar
Хэвлэсэн: (2019)

Improved Differential and Linear Trail Bounds for ASCON
-н: Solane El Hirch, зэрэг
Хэвлэсэн: (2022-12-01)

Big Five Trails: A Critical Review
-н: Najm Abood Najm
Хэвлэсэн: (2019-08-01)

Enacting Phenomenological Gestalts in Ultra-Trail Running: An Inductive Analysis of Trail Runners’ Courses of Experience
-н: Nadège Rochat, зэрэг
Хэвлэсэн: (2018-10-01)

SELECTED NATURE TRAILS OF PENANG ISLAND
-н: Malaysian Nature Society, issuing body
Хэвлэсэн: (1999)

Traals for the twenty-first century : planning, design, and managemant manual for multi use-trails /
-н: Ryan, Karen-Lee
Хэвлэсэн: (1993)

New techniques for trail bounds and application to differential trails in Keccak
-н: Silvia Mella, зэрэг
Хэвлэсэн: (2017-03-01)

The TRAIL in the Treatment of Human Cancer: An Update on Clinical Trials
-н: Martin Snajdauf, зэрэг
Хэвлэсэн: (2021-03-01)

Reflections about the geologic trails in Slovenia
-н: Rajko Pavlovec
Хэвлэсэн: (2002-12-01)

Turn TRAIL Into Better Anticancer Therapeutic Through TRAIL Fusion Proteins
-н: Yan Wang, зэрэг
Хэвлэсэн: (2025-01-01)

Design and Development of a Trailed Type Transplanter for Oil Palm Seedling
-н: El Pebrian, Darius
Хэвлэсэн: (2002)

STEM Trails: Enhancing STEM Education through Math Trails with Digital Technology
-н: Adi Nur Cahyono, зэрэг
Хэвлэсэн: (2024-05-01)

Mathematics Trails: Shallow and Deep Gamification
-н: Iwan Gurjanow, зэрэг
Хэвлэсэн: (2019-09-01)

Behind the Adaptive and Resistance Mechanisms of Cancer Stem Cells to TRAIL
-н: Adriana G. Quiroz-Reyes, зэрэг
Хэвлэсэн: (2021-07-01)

Enhancing radiation response by a second-generation TRAIL receptor agonist using a new in vitro organoid model system
-н: Shuraila F. Zerp, зэрэг
Хэвлэсэн: (2020-09-01)

Evaluation and Optimization of Restorative Environmental Perception of Treetop Trails: The Case of the Mountains-to-Sea Trail, Xiamen, China
-н: Honglin Wu, зэрэг
Хэвлэсэн: (2023-07-01)

The Oregan trail /
-н: 350759 Parkman, Francis
Хэвлэсэн: (1931)

Main Characteristics of Trails on Yarmouk Forest Reserve, A Quantitative Approach to Trails Assessment
-н: Loay Alzriqat, Sana’a Odat and Ismaiel Abuamoud
Хэвлэсэн: (2022-09-01)

Endogenous TRAIL-R4 critically impacts apoptotic and non-apoptotic TRAIL-induced signaling in cancer cells
-н: Anna-Christina Rambow, зэрэг
Хэвлэсэн: (2022-09-01)

Urban walks and town trails : origins, principles and sources/
-н: 410008 Goodney, Brian
Хэвлэсэн: (1974)