Low-Level Endothelial TRAIL-Receptor Expression Obstructs the CNS-Delivery of Angiopep-2 Functionalised TRAIL-Receptor Agonists for the Treatment of Glioblastoma

Low-Level Endothelial TRAIL-Receptor Expression Obstructs the CNS-Delivery of Angiopep-2 Functionalised TRAIL-Receptor Agonists for the Treatment of Glioblastoma

Glioblastoma (GBM) is the most malignant and aggressive form of glioma and is associated with a poor survival rate. Latest generation Tumour Necrosis Factor Related Apoptosis-Inducing Ligand (TRAIL)-based therapeutics potently induce apoptosis in cancer cells, including GBM cells, by binding to deat...

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Bibliographic Details
Main Authors: Nivetha Krishna Moorthy, Oliver Seifert, Stephan Eisler, Sara Weirich, Roland E. Kontermann, Markus Rehm, Gavin Fullstone
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Molecules
Subjects:
glioblastoma
TRAIL
angiopep-2
CNS delivery
receptor-mediated transcytosis
blood–brain barrier
Online Access:https://www.mdpi.com/1420-3049/26/24/7582

Internet

https://www.mdpi.com/1420-3049/26/24/7582

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