Targeted inhibition of STAT3 induces immunogenic cell death of hepatocellular carcinoma cells via glycolysis

Targeted inhibition of STAT3 induces immunogenic cell death of hepatocellular carcinoma cells via glycolysis

In hepatocellular carcinoma (HCC), the signal transducer and activator of transcription 3 (STAT3) is present in an overactive state that is closely related to tumour development and immune escape. STAT3 inhibition reshapes the tumour immune microenvironment, but the underlying mechanisms have not be...

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Bibliographic Details
Main Authors: Ya Li, Zhenwei Song, Qiuju Han, Huajun Zhao, Zhaoyi Pan, Zhengyang Lei, Jian Zhang
Format: Article
Language:English
Published: Wiley 2022-08-01
Series:Molecular Oncology
Subjects:
glycolysis
HCC
ICD
immune environment
STAT3
Online Access:https://doi.org/10.1002/1878-0261.13263

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