Microchip imaging cytometer: making healthcare available, accessible, and affordable
The Microchip Imaging Cytometer (MIC) is a class of integrated point-of-care detection systems based on the combination of optical microscopy and flow cytometry. MIC devices have the attributes of portability, cost-effectiveness, and adaptability while providing quantitative measurements to meet the...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Institue of Optics and Electronics, Chinese Academy of Sciences
2022-11-01
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| Series: | Opto-Electronic Advances |
| Subjects: | |
| Online Access: | https://www.oejournal.org/article/doi/10.29026/oea.2022.210130 |
| _version_ | 1811205714889146368 |
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| author | Xilong Yuan Todd Darcie Ziyin Wei J Stewart Aitchison |
| author_facet | Xilong Yuan Todd Darcie Ziyin Wei J Stewart Aitchison |
| author_sort | Xilong Yuan |
| collection | DOAJ |
| description | The Microchip Imaging Cytometer (MIC) is a class of integrated point-of-care detection systems based on the combination of optical microscopy and flow cytometry. MIC devices have the attributes of portability, cost-effectiveness, and adaptability while providing quantitative measurements to meet the needs of laboratory testing in a variety of healthcare settings. Based on the use of microfluidic chips, MIC requires less sample and can complete sample preparation automatically. Therefore, they can provide quantitative testing results simply using a finger prick specimen. The decreased reagent consumption and reduced form factor also help improve the accessibility and affordability of healthcare services in remote and resource-limited settings. In this article, we review recent developments of the Microchip Imaging Cytometer from the following aspects: clinical applications, microfluidic chip integration, imaging optics, and image acquisition. Following, we provide an outlook of the field and remark on promising technologies that may enable significant progress in the near future. |
| first_indexed | 2024-04-12T03:36:27Z |
| format | Article |
| id | doaj.art-4ed545b1abd749aab83d89d17fcbaace |
| institution | Directory Open Access Journal |
| issn | 2096-4579 |
| language | English |
| last_indexed | 2024-04-12T03:36:27Z |
| publishDate | 2022-11-01 |
| publisher | Institue of Optics and Electronics, Chinese Academy of Sciences |
| record_format | Article |
| series | Opto-Electronic Advances |
| spelling | doaj.art-4ed545b1abd749aab83d89d17fcbaace2022-12-22T03:49:25ZengInstitue of Optics and Electronics, Chinese Academy of SciencesOpto-Electronic Advances2096-45792022-11-0151111510.29026/oea.2022.210130OEA-2021-0130-Stewart-AitchisonMicrochip imaging cytometer: making healthcare available, accessible, and affordableXilong Yuan0Todd Darcie1Ziyin Wei2J Stewart Aitchison3Department of Electrical and Computer Engineering, University of Toronto, Toronto, ON, M5S 3G4, CanadaDepartment of Electrical and Computer Engineering, University of Toronto, Toronto, ON, M5S 3G4, CanadaDepartment of Electrical and Computer Engineering, University of Toronto, Toronto, ON, M5S 3G4, CanadaDepartment of Electrical and Computer Engineering, University of Toronto, Toronto, ON, M5S 3G4, CanadaThe Microchip Imaging Cytometer (MIC) is a class of integrated point-of-care detection systems based on the combination of optical microscopy and flow cytometry. MIC devices have the attributes of portability, cost-effectiveness, and adaptability while providing quantitative measurements to meet the needs of laboratory testing in a variety of healthcare settings. Based on the use of microfluidic chips, MIC requires less sample and can complete sample preparation automatically. Therefore, they can provide quantitative testing results simply using a finger prick specimen. The decreased reagent consumption and reduced form factor also help improve the accessibility and affordability of healthcare services in remote and resource-limited settings. In this article, we review recent developments of the Microchip Imaging Cytometer from the following aspects: clinical applications, microfluidic chip integration, imaging optics, and image acquisition. Following, we provide an outlook of the field and remark on promising technologies that may enable significant progress in the near future.https://www.oejournal.org/article/doi/10.29026/oea.2022.210130microchipmicrofluidicsflow cytometerimaging cytometerbiosensorspoint-of-care testingbiomedical engineering |
| spellingShingle | Xilong Yuan Todd Darcie Ziyin Wei J Stewart Aitchison Microchip imaging cytometer: making healthcare available, accessible, and affordable Opto-Electronic Advances microchip microfluidics flow cytometer imaging cytometer biosensors point-of-care testing biomedical engineering |
| title | Microchip imaging cytometer: making healthcare available, accessible, and affordable |
| title_full | Microchip imaging cytometer: making healthcare available, accessible, and affordable |
| title_fullStr | Microchip imaging cytometer: making healthcare available, accessible, and affordable |
| title_full_unstemmed | Microchip imaging cytometer: making healthcare available, accessible, and affordable |
| title_short | Microchip imaging cytometer: making healthcare available, accessible, and affordable |
| title_sort | microchip imaging cytometer making healthcare available accessible and affordable |
| topic | microchip microfluidics flow cytometer imaging cytometer biosensors point-of-care testing biomedical engineering |
| url | https://www.oejournal.org/article/doi/10.29026/oea.2022.210130 |
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