Thiophosphate Analogs of Coenzyme A and Its Precursors—Synthesis, Stability, and Biomimetic Potential

Thiophosphate Analogs of Coenzyme A and Its Precursors—Synthesis, Stability, and Biomimetic Potential

Coenzyme A (CoA) is ubiquitous and essential for key cellular processes in any living organism. Primary degradation of CoA occurs by enzyme-mediated pyrophosphate hydrolysis intracellularly and extracellularly to form adenosine 3’,5’-diphosphate and 4’-phosphopantetheine (PPanSH). The latter can be...

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Bibliographic Details
Main Authors: Christian Löcherer, Elif Tosun, Hannah Backes, Andres Jäschke
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Biomolecules
Subjects:
CoA
PPanSH
phosphorothioate
CoA biosynthesis
CoA degradation
Nudt7
Online Access:https://www.mdpi.com/2218-273X/12/8/1065

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