The death rate of COVID-19 infection in different SARS-CoV-2 variants was related to C-reactive protein gene polymorphisms
Abstract The serum level of C-reactive protein (CRP) is a significant independent risk factor for Coronavirus disease 2019 (COVID-19). A link was found between serum CRP and genetic diversity within the CRP gene in earlier research. This study examined whether CRP rs1205 and rs1800947 polymorphisms...
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| Format: | Article |
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Nature Portfolio
2024-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-51422-y |
| _version_ | 1797363364345675776 |
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| author | Sahar Sadeghi Mofrad Shayan Boozarjomehri Amnieh Mohammad Reza Pakzad Mina Zardadi Morteza Ghazanfari Jajin Enayat Anvari Sina Moghaddam Abolfazl Fateh |
| author_facet | Sahar Sadeghi Mofrad Shayan Boozarjomehri Amnieh Mohammad Reza Pakzad Mina Zardadi Morteza Ghazanfari Jajin Enayat Anvari Sina Moghaddam Abolfazl Fateh |
| author_sort | Sahar Sadeghi Mofrad |
| collection | DOAJ |
| description | Abstract The serum level of C-reactive protein (CRP) is a significant independent risk factor for Coronavirus disease 2019 (COVID-19). A link was found between serum CRP and genetic diversity within the CRP gene in earlier research. This study examined whether CRP rs1205 and rs1800947 polymorphisms were associated with COVID-19 mortality among various severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) variants. We genotyped CRP rs1205 and rs1800947 polymorphisms in 2023 deceased and 2307 recovered patients using the polymerase chain reaction-restriction fragment length polymorphism method. There was a significant difference between the recovered and the deceased patients in terms of the minor allele frequency of CRP rs1205 T and rs1800947 G. In all three variants, COVID-19 mortality rates were associated with CRP rs1800947 GG genotype. Furthermore, CRP rs1205 CC and rs1800947 GG genotypes showed higher CRP levels. It was found that the G-T haplotype was prevalent in all SARS-CoV-2 variants. The C–C and C–T haplotypes were statistically significant in Delta and Omicron BA.5 variants, respectively. In conclusion, polymorphisms within the CRP gene may relate to serum CRP levels and mortality among COVID-19 patients. In order to verify the utility of CRP polymorphism correlation in predicting COVID-19 mortality, a replication of these results is needed. |
| first_indexed | 2024-03-08T16:20:20Z |
| format | Article |
| id | doaj.art-4ed61f8df7834964a98a542971cfdd4a |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-08T16:20:20Z |
| publishDate | 2024-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-4ed61f8df7834964a98a542971cfdd4a2024-01-07T12:24:09ZengNature PortfolioScientific Reports2045-23222024-01-011411810.1038/s41598-024-51422-yThe death rate of COVID-19 infection in different SARS-CoV-2 variants was related to C-reactive protein gene polymorphismsSahar Sadeghi Mofrad0Shayan Boozarjomehri Amnieh1Mohammad Reza Pakzad2Mina Zardadi3Morteza Ghazanfari Jajin4Enayat Anvari5Sina Moghaddam6Abolfazl Fateh7Department of Microbiology, Islamic Azad University of Central Tehran BranchFaculty of Veterinary Medicine, Tabriz Medical Science Branch, Islamic Azad UniversityFaculty of Veterinary Medicine, Tabriz Medical Science Branch, Islamic Azad UniversityDepartment of Mycobacteriology and Pulmonary Research, Pasteur Institute of IranDepartment of Mycobacteriology and Pulmonary Research, Pasteur Institute of IranClinical Research Development Unit, Shahid Mostafa Khomeini Hospital, Ilam University of Medical ScienceDepartment of Mycobacteriology and Pulmonary Research, Pasteur Institute of IranDepartment of Mycobacteriology and Pulmonary Research, Pasteur Institute of IranAbstract The serum level of C-reactive protein (CRP) is a significant independent risk factor for Coronavirus disease 2019 (COVID-19). A link was found between serum CRP and genetic diversity within the CRP gene in earlier research. This study examined whether CRP rs1205 and rs1800947 polymorphisms were associated with COVID-19 mortality among various severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) variants. We genotyped CRP rs1205 and rs1800947 polymorphisms in 2023 deceased and 2307 recovered patients using the polymerase chain reaction-restriction fragment length polymorphism method. There was a significant difference between the recovered and the deceased patients in terms of the minor allele frequency of CRP rs1205 T and rs1800947 G. In all three variants, COVID-19 mortality rates were associated with CRP rs1800947 GG genotype. Furthermore, CRP rs1205 CC and rs1800947 GG genotypes showed higher CRP levels. It was found that the G-T haplotype was prevalent in all SARS-CoV-2 variants. The C–C and C–T haplotypes were statistically significant in Delta and Omicron BA.5 variants, respectively. In conclusion, polymorphisms within the CRP gene may relate to serum CRP levels and mortality among COVID-19 patients. In order to verify the utility of CRP polymorphism correlation in predicting COVID-19 mortality, a replication of these results is needed.https://doi.org/10.1038/s41598-024-51422-y |
| spellingShingle | Sahar Sadeghi Mofrad Shayan Boozarjomehri Amnieh Mohammad Reza Pakzad Mina Zardadi Morteza Ghazanfari Jajin Enayat Anvari Sina Moghaddam Abolfazl Fateh The death rate of COVID-19 infection in different SARS-CoV-2 variants was related to C-reactive protein gene polymorphisms Scientific Reports |
| title | The death rate of COVID-19 infection in different SARS-CoV-2 variants was related to C-reactive protein gene polymorphisms |
| title_full | The death rate of COVID-19 infection in different SARS-CoV-2 variants was related to C-reactive protein gene polymorphisms |
| title_fullStr | The death rate of COVID-19 infection in different SARS-CoV-2 variants was related to C-reactive protein gene polymorphisms |
| title_full_unstemmed | The death rate of COVID-19 infection in different SARS-CoV-2 variants was related to C-reactive protein gene polymorphisms |
| title_short | The death rate of COVID-19 infection in different SARS-CoV-2 variants was related to C-reactive protein gene polymorphisms |
| title_sort | death rate of covid 19 infection in different sars cov 2 variants was related to c reactive protein gene polymorphisms |
| url | https://doi.org/10.1038/s41598-024-51422-y |
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