Combined Effects of Methylated Cytosine and Molecular Crowding on the Thermodynamic Stability of DNA Duplexes

Combined Effects of Methylated Cytosine and Molecular Crowding on the Thermodynamic Stability of DNA Duplexes

Methylated cytosine within CpG dinucleotides is a key factor for epigenetic gene regulation. It has been revealed that methylated cytosine decreases DNA backbone flexibility and increases the thermal stability of DNA. Although the molecular environment is an important factor for the structure, therm...

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Bibliographic Details
Main Authors: Mitsuki Tsuruta, Yui Sugitani, Naoki Sugimoto, Daisuke Miyoshi
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
methylated cytosine
molecular crowding
osmolyte
epigenetics
thermodynamics
Online Access:https://www.mdpi.com/1422-0067/22/2/947

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