Phytoestrogens for Cancer Prevention and Treatment
Phytoestrogens are a large group of natural compounds found in more than 300 plants. They have a close structural similarity to estrogens, which allow them to bind to both estrogen receptors (ER), ERα and ERβ, presenting a weak estrogenic activity. Phytoestrogens have been described as antioxidant,...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Biology |
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| Online Access: | https://www.mdpi.com/2079-7737/9/12/427 |
| _version_ | 1797546456069963776 |
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| author | Margalida Torrens-Mas Pilar Roca |
| author_facet | Margalida Torrens-Mas Pilar Roca |
| author_sort | Margalida Torrens-Mas |
| collection | DOAJ |
| description | Phytoestrogens are a large group of natural compounds found in more than 300 plants. They have a close structural similarity to estrogens, which allow them to bind to both estrogen receptors (ER), ERα and ERβ, presenting a weak estrogenic activity. Phytoestrogens have been described as antioxidant, anti-inflammatory, anti-thrombotic, anti-allergic, and anti-tumoral agents. Their role in cancer prevention has been well documented, although their impact on treatment efficiency is controversial. Several reports suggest that phytoestrogens may interfere with the effect of anti-cancer drugs through the regulation of oxidative stress and other mechanisms. Furthermore, some phytoestrogens could exert a protective effect on healthy cells, thus reducing the secondary effects of cancer treatment. In this review, we have studied the recent research in this area to find evidence for the role of phytoestrogens in cancer prevention and therapy efficacy. |
| first_indexed | 2024-03-10T14:30:21Z |
| format | Article |
| id | doaj.art-4ed990afb41748ddb8c96bced9da6c6f |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-10T14:30:21Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-4ed990afb41748ddb8c96bced9da6c6f2023-11-20T22:39:11ZengMDPI AGBiology2079-77372020-11-0191242710.3390/biology9120427Phytoestrogens for Cancer Prevention and TreatmentMargalida Torrens-Mas0Pilar Roca1Grupo Multidisciplinar de Oncología Traslacional, Institut Universitari d’Investigació en Ciències de la Salut, Universitat de les Illes Balears, 07122 Palma, SpainGrupo Multidisciplinar de Oncología Traslacional, Institut Universitari d’Investigació en Ciències de la Salut, Universitat de les Illes Balears, 07122 Palma, SpainPhytoestrogens are a large group of natural compounds found in more than 300 plants. They have a close structural similarity to estrogens, which allow them to bind to both estrogen receptors (ER), ERα and ERβ, presenting a weak estrogenic activity. Phytoestrogens have been described as antioxidant, anti-inflammatory, anti-thrombotic, anti-allergic, and anti-tumoral agents. Their role in cancer prevention has been well documented, although their impact on treatment efficiency is controversial. Several reports suggest that phytoestrogens may interfere with the effect of anti-cancer drugs through the regulation of oxidative stress and other mechanisms. Furthermore, some phytoestrogens could exert a protective effect on healthy cells, thus reducing the secondary effects of cancer treatment. In this review, we have studied the recent research in this area to find evidence for the role of phytoestrogens in cancer prevention and therapy efficacy.https://www.mdpi.com/2079-7737/9/12/427phytoestrogenscancer preventioncancer treatmentantioxidants |
| spellingShingle | Margalida Torrens-Mas Pilar Roca Phytoestrogens for Cancer Prevention and Treatment Biology phytoestrogens cancer prevention cancer treatment antioxidants |
| title | Phytoestrogens for Cancer Prevention and Treatment |
| title_full | Phytoestrogens for Cancer Prevention and Treatment |
| title_fullStr | Phytoestrogens for Cancer Prevention and Treatment |
| title_full_unstemmed | Phytoestrogens for Cancer Prevention and Treatment |
| title_short | Phytoestrogens for Cancer Prevention and Treatment |
| title_sort | phytoestrogens for cancer prevention and treatment |
| topic | phytoestrogens cancer prevention cancer treatment antioxidants |
| url | https://www.mdpi.com/2079-7737/9/12/427 |
| work_keys_str_mv | AT margalidatorrensmas phytoestrogensforcancerpreventionandtreatment AT pilarroca phytoestrogensforcancerpreventionandtreatment |