Quantifying iodine concentration in the normal bowel wall using dual-energy CT: influence of patient and contrast characteristics
Abstract This study aimed to establish quantitative references of the normal bowel wall iodine concentration (BWIC) using dual energy CT (DECT). This single-center retrospective study included 248 patients with no history of gastrointestinal disease who underwent abdominal contrast-enhanced DECT bet...
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Nature Portfolio
2023-12-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-50238-6 |
| _version_ | 1797259278045675520 |
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| author | Majida Nehnahi Gabriel Simon Romain Moinet Gael Piton Camille Camelin Maxime Ronot Éric Delabrousse Paul Calame |
| author_facet | Majida Nehnahi Gabriel Simon Romain Moinet Gael Piton Camille Camelin Maxime Ronot Éric Delabrousse Paul Calame |
| author_sort | Majida Nehnahi |
| collection | DOAJ |
| description | Abstract This study aimed to establish quantitative references of the normal bowel wall iodine concentration (BWIC) using dual energy CT (DECT). This single-center retrospective study included 248 patients with no history of gastrointestinal disease who underwent abdominal contrast-enhanced DECT between January and April 2022. The BWIC was normalized by the iodine concentration of upper abdominal organs (BWICorgan,) and the iodine concentration (IC) of the aorta (BWICaorta). BWIC decreased from the stomach to the rectum (mean 2.16 ± 0.63 vs. 2.19 ± 0.63 vs. 2.1 ± 0.58 vs. 1.67 ± 0.47 vs. 1.31 ± 0.4 vs. 1.18 ± 0.34 vs. 0.94 ± 0.26 mgI/mL for the stomach, duodenum, jejunum, ileum, right colon, left colon and rectum, respectively; P < 0.001). By multivariate analysis, BWIC was associated with a higher BMI (OR:1.01, 95% CI 1.00–1.02, P < 0.001) and with a higher injected contrast dose (OR: 1.51; 95% CI 1.36–1.66, P < 0.001 and 2.06; 95% CI 1.88–2.26, P < 0.001 for 500 mgI/kg and 600 mgI/kg doses taking 400 mgI/kg dose as reference). The BWICorgan was shown independent from patients and contrast-related variables while the BWICaorta was not. BWIC varies according to bowel segments and is dependent on the total iodine dose injected. It shall be normalized with the IC of the upper abdominal organs. |
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| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-24T23:06:53Z |
| publishDate | 2023-12-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj.art-4ed9f11f6933416dbc00a7d9bc4e23852024-03-17T12:27:11ZengNature PortfolioScientific Reports2045-23222023-12-011311910.1038/s41598-023-50238-6Quantifying iodine concentration in the normal bowel wall using dual-energy CT: influence of patient and contrast characteristicsMajida Nehnahi0Gabriel Simon1Romain Moinet2Gael Piton3Camille Camelin4Maxime Ronot5Éric Delabrousse6Paul Calame7Department of Radiology, University of Bourgogne Franche-Comté, CHU BesançonDepartment of Radiology, University of Bourgogne Franche-Comté, CHU BesançonDepartment of Radiology, University of Bourgogne Franche-Comté, CHU BesançonMedical Intensive Care Unit, University of Bourgogne Franche-Comté, CHU BesançonDepartment of Radiology, University of Bourgogne Franche-Comté, CHU BesançonDepartment of Radiology, University Hospitals Paris Nord Val-de-Seine, AP-HP, BeaujonDepartment of Radiology, University of Bourgogne Franche-Comté, CHU BesançonDepartment of Radiology, University of Bourgogne Franche-Comté, CHU BesançonAbstract This study aimed to establish quantitative references of the normal bowel wall iodine concentration (BWIC) using dual energy CT (DECT). This single-center retrospective study included 248 patients with no history of gastrointestinal disease who underwent abdominal contrast-enhanced DECT between January and April 2022. The BWIC was normalized by the iodine concentration of upper abdominal organs (BWICorgan,) and the iodine concentration (IC) of the aorta (BWICaorta). BWIC decreased from the stomach to the rectum (mean 2.16 ± 0.63 vs. 2.19 ± 0.63 vs. 2.1 ± 0.58 vs. 1.67 ± 0.47 vs. 1.31 ± 0.4 vs. 1.18 ± 0.34 vs. 0.94 ± 0.26 mgI/mL for the stomach, duodenum, jejunum, ileum, right colon, left colon and rectum, respectively; P < 0.001). By multivariate analysis, BWIC was associated with a higher BMI (OR:1.01, 95% CI 1.00–1.02, P < 0.001) and with a higher injected contrast dose (OR: 1.51; 95% CI 1.36–1.66, P < 0.001 and 2.06; 95% CI 1.88–2.26, P < 0.001 for 500 mgI/kg and 600 mgI/kg doses taking 400 mgI/kg dose as reference). The BWICorgan was shown independent from patients and contrast-related variables while the BWICaorta was not. BWIC varies according to bowel segments and is dependent on the total iodine dose injected. It shall be normalized with the IC of the upper abdominal organs.https://doi.org/10.1038/s41598-023-50238-6 |
| spellingShingle | Majida Nehnahi Gabriel Simon Romain Moinet Gael Piton Camille Camelin Maxime Ronot Éric Delabrousse Paul Calame Quantifying iodine concentration in the normal bowel wall using dual-energy CT: influence of patient and contrast characteristics Scientific Reports |
| title | Quantifying iodine concentration in the normal bowel wall using dual-energy CT: influence of patient and contrast characteristics |
| title_full | Quantifying iodine concentration in the normal bowel wall using dual-energy CT: influence of patient and contrast characteristics |
| title_fullStr | Quantifying iodine concentration in the normal bowel wall using dual-energy CT: influence of patient and contrast characteristics |
| title_full_unstemmed | Quantifying iodine concentration in the normal bowel wall using dual-energy CT: influence of patient and contrast characteristics |
| title_short | Quantifying iodine concentration in the normal bowel wall using dual-energy CT: influence of patient and contrast characteristics |
| title_sort | quantifying iodine concentration in the normal bowel wall using dual energy ct influence of patient and contrast characteristics |
| url | https://doi.org/10.1038/s41598-023-50238-6 |
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