Patterns of cortical grey matter thickness reduction in multiple sclerosis
Abstract Objective To examine the patterns of cortical gray matter thickness in multiple sclerosis (MS) patients. Methods Seventy‐four MS patients—clinically isolated syndrome (4%), relapsing–remitting MS (79%), and progressive MS (17%)—and 21 healthy controls (HCs) underwent 1.5 Tesla T1‐weighted 3...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-04-01
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| Series: | Brain and Behavior |
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| Online Access: | https://doi.org/10.1002/brb3.2050 |
| _version_ | 1818740656122626048 |
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| author | Juichi Fujimori Kazuo Fujihara Mike Wattjes Ichiro Nakashima |
| author_facet | Juichi Fujimori Kazuo Fujihara Mike Wattjes Ichiro Nakashima |
| author_sort | Juichi Fujimori |
| collection | DOAJ |
| description | Abstract Objective To examine the patterns of cortical gray matter thickness in multiple sclerosis (MS) patients. Methods Seventy‐four MS patients—clinically isolated syndrome (4%), relapsing–remitting MS (79%), and progressive MS (17%)—and 21 healthy controls (HCs) underwent 1.5 Tesla T1‐weighted 3D MRI examinations to measure brain cortical thickness in a total of 68 regions of interest. Using hierarchical cluster analysis with multivariate cortical thickness data, cortical thickness reduction patterns were cross‐sectionally investigated in MS patients. Results The MS patients were grouped into three major clusters (Clusters 1, 2, and 3). Most of the regional cortical thickness values were equivalent between the HCs and Cluster 1, but decreased in the order of Clusters 2 and 3. Only the thicknesses of the temporal lobe cortices (the bilateral superior and left middle temporal cortex, as well as the left fusiform cortex) were significantly different among Clusters 1, 2, and 3. In contrast, temporal pole thickness reduction was evident exclusively in Cluster 3, which was also characterized by increased lesion loads in the temporal pole and the adjacent juxtacortical white matter, dilatation of the inferior horn of the lateral ventricle, severe whole‐brain volume reduction, and longer disease duration. Although cortical atrophy was significantly more common in the progressive phase, approximately half of the MS patients with the severe cortical atrophy pattern had relapsing–remitting disease. Conclusion Cortical thickness reduction patterns in MS are mostly characterized by the degree of temporal lobe cortical atrophy, which may start in the relapsing–remitting phase. Among the temporal lobe cortices, the neurodegenerative change may accelerate in the temporal pole in the progressive phase. |
| first_indexed | 2024-12-18T01:44:11Z |
| format | Article |
| id | doaj.art-4edaf31729324c8baa75351c7f6f6f1d |
| institution | Directory Open Access Journal |
| issn | 2162-3279 |
| language | English |
| last_indexed | 2024-12-18T01:44:11Z |
| publishDate | 2021-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj.art-4edaf31729324c8baa75351c7f6f6f1d2022-12-21T21:25:13ZengWileyBrain and Behavior2162-32792021-04-01114n/an/a10.1002/brb3.2050Patterns of cortical grey matter thickness reduction in multiple sclerosisJuichi Fujimori0Kazuo Fujihara1Mike Wattjes2Ichiro Nakashima3Division of Neurology Tohoku Medical and Pharmaceutical University Sendai JapanDepartment of Multiple Sclerosis Therapeutics Tohoku University Graduate School of Medicine Sendai JapanDepartment of Diagnostic and Interventional Neuroradiology Hannover Medical School Hannover GermanyDivision of Neurology Tohoku Medical and Pharmaceutical University Sendai JapanAbstract Objective To examine the patterns of cortical gray matter thickness in multiple sclerosis (MS) patients. Methods Seventy‐four MS patients—clinically isolated syndrome (4%), relapsing–remitting MS (79%), and progressive MS (17%)—and 21 healthy controls (HCs) underwent 1.5 Tesla T1‐weighted 3D MRI examinations to measure brain cortical thickness in a total of 68 regions of interest. Using hierarchical cluster analysis with multivariate cortical thickness data, cortical thickness reduction patterns were cross‐sectionally investigated in MS patients. Results The MS patients were grouped into three major clusters (Clusters 1, 2, and 3). Most of the regional cortical thickness values were equivalent between the HCs and Cluster 1, but decreased in the order of Clusters 2 and 3. Only the thicknesses of the temporal lobe cortices (the bilateral superior and left middle temporal cortex, as well as the left fusiform cortex) were significantly different among Clusters 1, 2, and 3. In contrast, temporal pole thickness reduction was evident exclusively in Cluster 3, which was also characterized by increased lesion loads in the temporal pole and the adjacent juxtacortical white matter, dilatation of the inferior horn of the lateral ventricle, severe whole‐brain volume reduction, and longer disease duration. Although cortical atrophy was significantly more common in the progressive phase, approximately half of the MS patients with the severe cortical atrophy pattern had relapsing–remitting disease. Conclusion Cortical thickness reduction patterns in MS are mostly characterized by the degree of temporal lobe cortical atrophy, which may start in the relapsing–remitting phase. Among the temporal lobe cortices, the neurodegenerative change may accelerate in the temporal pole in the progressive phase.https://doi.org/10.1002/brb3.2050cluster analysiscortical gray matterMRImultiple sclerosistemporal pole |
| spellingShingle | Juichi Fujimori Kazuo Fujihara Mike Wattjes Ichiro Nakashima Patterns of cortical grey matter thickness reduction in multiple sclerosis Brain and Behavior cluster analysis cortical gray matter MRI multiple sclerosis temporal pole |
| title | Patterns of cortical grey matter thickness reduction in multiple sclerosis |
| title_full | Patterns of cortical grey matter thickness reduction in multiple sclerosis |
| title_fullStr | Patterns of cortical grey matter thickness reduction in multiple sclerosis |
| title_full_unstemmed | Patterns of cortical grey matter thickness reduction in multiple sclerosis |
| title_short | Patterns of cortical grey matter thickness reduction in multiple sclerosis |
| title_sort | patterns of cortical grey matter thickness reduction in multiple sclerosis |
| topic | cluster analysis cortical gray matter MRI multiple sclerosis temporal pole |
| url | https://doi.org/10.1002/brb3.2050 |
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