A simple and eco-friendly microwave mediated route the synthesis of novel antimicrobial substituted quinoline-2-thiones
An eco-friendly and efficient method was developed for the preparation of a new series of sulfur-containing quinolinthiones. Compounds 6a–o were synthesized from 4-methyl-2-thiocoumarin and arylhydrazides using water as a solvent under microwave irradiation. Some noteworthy features of our novel met...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2018-10-01
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| Series: | Green Chemistry Letters and Reviews |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/17518253.2018.1536228 |
| _version_ | 1818041560761106432 |
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| author | Mohammed H. Geesi Azzam Ahmed Mohammed AL-Hadedi Mohammed A. Bakht Abdellah Kaiba Meryem Boukili Mohammed B. Alshammari Oussama Dehbi Yassine Riadi |
| author_facet | Mohammed H. Geesi Azzam Ahmed Mohammed AL-Hadedi Mohammed A. Bakht Abdellah Kaiba Meryem Boukili Mohammed B. Alshammari Oussama Dehbi Yassine Riadi |
| author_sort | Mohammed H. Geesi |
| collection | DOAJ |
| description | An eco-friendly and efficient method was developed for the preparation of a new series of sulfur-containing quinolinthiones. Compounds 6a–o were synthesized from 4-methyl-2-thiocoumarin and arylhydrazides using water as a solvent under microwave irradiation. Some noteworthy features of our novel method are its cleanliness, short reaction time and high conversion rate, and the reaction proceeds (profiles) using a simple procedure. All of the prepared compounds were screened for their antibacterial efficacy in vitro using the disc diffusion method against bacterial strains. Compound (6j) showed the greatest potency with a 16 and 19 mm inhibition zone against Klebsiella pneumonia and Staphylococcus aureus, respectively. |
| first_indexed | 2024-12-10T08:32:22Z |
| format | Article |
| id | doaj.art-4edce16a4cbf47378c10b89ef4da8b49 |
| institution | Directory Open Access Journal |
| issn | 1751-8253 1751-7192 |
| language | English |
| last_indexed | 2024-12-10T08:32:22Z |
| publishDate | 2018-10-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Green Chemistry Letters and Reviews |
| spelling | doaj.art-4edce16a4cbf47378c10b89ef4da8b492022-12-22T01:56:04ZengTaylor & Francis GroupGreen Chemistry Letters and Reviews1751-82531751-71922018-10-0111446947510.1080/17518253.2018.15362281536228A simple and eco-friendly microwave mediated route the synthesis of novel antimicrobial substituted quinoline-2-thionesMohammed H. Geesi0Azzam Ahmed Mohammed AL-Hadedi1Mohammed A. Bakht2Abdellah Kaiba3Meryem Boukili4Mohammed B. Alshammari5Oussama Dehbi6Yassine Riadi7Prince Sattam bin Abdulaziz UniversityUniversity of MosulPrince Sattam bin Abdulaziz UniversityPrince Sattam bin Abdulaziz UniversityMoulay Ismail University Faculty of SciencesPrince Sattam bin Abdulaziz UniversityJouf UniversityPrince Sattam Bin Abdulaziz UniversityAn eco-friendly and efficient method was developed for the preparation of a new series of sulfur-containing quinolinthiones. Compounds 6a–o were synthesized from 4-methyl-2-thiocoumarin and arylhydrazides using water as a solvent under microwave irradiation. Some noteworthy features of our novel method are its cleanliness, short reaction time and high conversion rate, and the reaction proceeds (profiles) using a simple procedure. All of the prepared compounds were screened for their antibacterial efficacy in vitro using the disc diffusion method against bacterial strains. Compound (6j) showed the greatest potency with a 16 and 19 mm inhibition zone against Klebsiella pneumonia and Staphylococcus aureus, respectively.http://dx.doi.org/10.1080/17518253.2018.1536228Green chemistryquinolinthionesmethyl-2-thiocoumarinwatermicrowave |
| spellingShingle | Mohammed H. Geesi Azzam Ahmed Mohammed AL-Hadedi Mohammed A. Bakht Abdellah Kaiba Meryem Boukili Mohammed B. Alshammari Oussama Dehbi Yassine Riadi A simple and eco-friendly microwave mediated route the synthesis of novel antimicrobial substituted quinoline-2-thiones Green Chemistry Letters and Reviews Green chemistry quinolinthiones methyl-2-thiocoumarin water microwave |
| title | A simple and eco-friendly microwave mediated route the synthesis of novel antimicrobial substituted quinoline-2-thiones |
| title_full | A simple and eco-friendly microwave mediated route the synthesis of novel antimicrobial substituted quinoline-2-thiones |
| title_fullStr | A simple and eco-friendly microwave mediated route the synthesis of novel antimicrobial substituted quinoline-2-thiones |
| title_full_unstemmed | A simple and eco-friendly microwave mediated route the synthesis of novel antimicrobial substituted quinoline-2-thiones |
| title_short | A simple and eco-friendly microwave mediated route the synthesis of novel antimicrobial substituted quinoline-2-thiones |
| title_sort | simple and eco friendly microwave mediated route the synthesis of novel antimicrobial substituted quinoline 2 thiones |
| topic | Green chemistry quinolinthiones methyl-2-thiocoumarin water microwave |
| url | http://dx.doi.org/10.1080/17518253.2018.1536228 |
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