Lactoferrin: A glycoprotein that plays an active role in human health
Lactoferrin (Lf), existing widely in human and mammalian milk, is a multifunctional glycoprotein with many functions, such as immune regulation, anti-inflammation, antibacterial, antiviral, and antioxidant. These extensive functions largely attribute to its ability to chelate iron and interfere with...
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| Format: | Article |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.1018336/full |
| _version_ | 1797955696053977088 |
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| author | Xiang Cao Yang Ren Qinyue Lu Kun Wang Yanni Wu YuHao Wang Yihui Zhang Xiang-shun Cui Zhangping Yang Zhangping Yang Zhi Chen Zhi Chen Zhi Chen |
| author_facet | Xiang Cao Yang Ren Qinyue Lu Kun Wang Yanni Wu YuHao Wang Yihui Zhang Xiang-shun Cui Zhangping Yang Zhangping Yang Zhi Chen Zhi Chen Zhi Chen |
| author_sort | Xiang Cao |
| collection | DOAJ |
| description | Lactoferrin (Lf), existing widely in human and mammalian milk, is a multifunctional glycoprotein with many functions, such as immune regulation, anti-inflammation, antibacterial, antiviral, and antioxidant. These extensive functions largely attribute to its ability to chelate iron and interfere with the cellular receptors of pathogenic microorganisms and their hosts. Moreover, it is non-toxic and has good compatibility with other supplements. Thus, Lf has been widely used in food nutrition, drug carriers, biotechnology, and feed development. Although Lf has been continuously explored and studied, a more comprehensive and systematic compendium is still required. This review presents the recent advances in the structure and physicochemical properties of Lf as well as clinical studies on human diseases, with the aim of providing a reference for further research of Lf and the development of its related functional products. |
| first_indexed | 2024-04-10T23:38:14Z |
| format | Article |
| id | doaj.art-4edd0c2f99764b848fccc8b0a5f1dafa |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-10T23:38:14Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-4edd0c2f99764b848fccc8b0a5f1dafa2023-01-11T15:23:00ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-01-01910.3389/fnut.2022.10183361018336Lactoferrin: A glycoprotein that plays an active role in human healthXiang Cao0Yang Ren1Qinyue Lu2Kun Wang3Yanni Wu4YuHao Wang5Yihui Zhang6Xiang-shun Cui7Zhangping Yang8Zhangping Yang9Zhi Chen10Zhi Chen11Zhi Chen12College of Animal Science and Technology, Yangzhou University, Yangzhou, ChinaCollege of Animal Science and Technology, Yangzhou University, Yangzhou, ChinaCollege of Animal Science and Technology, Yangzhou University, Yangzhou, ChinaCollege of Animal Science and Technology, Yangzhou University, Yangzhou, ChinaCollege of Animal Science and Technology, Yangzhou University, Yangzhou, ChinaCollege of Animal Science and Technology, Yangzhou University, Yangzhou, ChinaCollege of Animal Science and Technology, Yangzhou University, Yangzhou, ChinaDepartment of Animal Science, Laboratory of Animal Developmental Biology, Chungbuk National University, Cheongju, Republic of KoreaCollege of Animal Science and Technology, Yangzhou University, Yangzhou, ChinaJoint International Research Laboratory of Agriculture and Agri-Product Safety, Ministry of Education, Yangzhou University, Yangzhou, ChinaCollege of Animal Science and Technology, Yangzhou University, Yangzhou, ChinaJoint International Research Laboratory of Agriculture and Agri-Product Safety, Ministry of Education, Yangzhou University, Yangzhou, ChinaInternational Joint Research Laboratory in Universities of Jiangsu Province of China for Domestic Animal Germplasm Resources and Genetic Improvement, Yangzhou, ChinaLactoferrin (Lf), existing widely in human and mammalian milk, is a multifunctional glycoprotein with many functions, such as immune regulation, anti-inflammation, antibacterial, antiviral, and antioxidant. These extensive functions largely attribute to its ability to chelate iron and interfere with the cellular receptors of pathogenic microorganisms and their hosts. Moreover, it is non-toxic and has good compatibility with other supplements. Thus, Lf has been widely used in food nutrition, drug carriers, biotechnology, and feed development. Although Lf has been continuously explored and studied, a more comprehensive and systematic compendium is still required. This review presents the recent advances in the structure and physicochemical properties of Lf as well as clinical studies on human diseases, with the aim of providing a reference for further research of Lf and the development of its related functional products.https://www.frontiersin.org/articles/10.3389/fnut.2022.1018336/fulllactoferrinantimicrobialanticancerimmunoregulationexpression regulation |
| spellingShingle | Xiang Cao Yang Ren Qinyue Lu Kun Wang Yanni Wu YuHao Wang Yihui Zhang Xiang-shun Cui Zhangping Yang Zhangping Yang Zhi Chen Zhi Chen Zhi Chen Lactoferrin: A glycoprotein that plays an active role in human health Frontiers in Nutrition lactoferrin antimicrobial anticancer immunoregulation expression regulation |
| title | Lactoferrin: A glycoprotein that plays an active role in human health |
| title_full | Lactoferrin: A glycoprotein that plays an active role in human health |
| title_fullStr | Lactoferrin: A glycoprotein that plays an active role in human health |
| title_full_unstemmed | Lactoferrin: A glycoprotein that plays an active role in human health |
| title_short | Lactoferrin: A glycoprotein that plays an active role in human health |
| title_sort | lactoferrin a glycoprotein that plays an active role in human health |
| topic | lactoferrin antimicrobial anticancer immunoregulation expression regulation |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.1018336/full |
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