Comparison of the Treatment Efficacy of Rosuvastatin versus Atorvastatin Loading Prior to Percutaneous Coronary Intervention in ST-Segment Elevation Myocardial Infarction
The aim of this study was to compare the effect of a single high-dose rosuvastatin versus atorvastatin preloading in ST-elevation myocardial infarction (STEMI) patients receiving primary percutaneous coronary intervention (PCI.) Methods: A total of 99 patients presented with STEMI and were randomly...
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| Format: | Article |
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MDPI AG
2022-08-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/17/5142 |
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| author | Esraa M. Adel Ahmed A. Elberry Ahmed Abdel Aziz Ibrahim A. Naguib Badrah S. Alghamdi Raghda R. S. Hussein |
| author_facet | Esraa M. Adel Ahmed A. Elberry Ahmed Abdel Aziz Ibrahim A. Naguib Badrah S. Alghamdi Raghda R. S. Hussein |
| author_sort | Esraa M. Adel |
| collection | DOAJ |
| description | The aim of this study was to compare the effect of a single high-dose rosuvastatin versus atorvastatin preloading in ST-elevation myocardial infarction (STEMI) patients receiving primary percutaneous coronary intervention (PCI.) Methods: A total of 99 patients presented with STEMI and were randomly divided into three groups—a control group (<i>n</i> = 33) with no statin treatment, an atorvastatin group (<i>n</i> = 33) with a single 80 mg atorvastatin dose and the rosuvastatin group (<i>n</i> = 33) with a single 40 mg rosuvastatin dose in the emergency room (ER) prior to PCI. Post-interventional thrombolysis in myocardial infarction (TIMI) flow grade and corrected TIMI frame count (CTFC) were recorded, and ST-segment resolution was measured. Results: CTFC was significantly lower for the atorvastatin group (<i>p</i>-value < 0.01) than in the control group. A final TIMI flow grade 3 was achieved in 32 (97.0%) patients in the rosuvastatin group and 28 (84.8%) patients in the atorvastatin group compared with only 25 (75.8%) patients in the control group (<i>p</i> = 0.014). Peak CK-MB in the rosuvastatin group (263.2 [207.2–315.6]) and the atorvastatin group (208 [151.0–314.1]) was lower compared to that in the control group (398.4 [303.9–459.3]); <i>p</i> < 0.001. Conclusions: A single extensive dose of lipophilic atorvastatin prior to primary PCI in STEMI patients showed better improvement in microvascular myocardial perfusion compared to hydrophilic rosuvastatin. |
| first_indexed | 2024-03-10T01:38:19Z |
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| id | doaj.art-4edd5f2c925c4e06a72c97c882731be2 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T01:38:19Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-4edd5f2c925c4e06a72c97c882731be22023-11-23T13:28:45ZengMDPI AGJournal of Clinical Medicine2077-03832022-08-011117514210.3390/jcm11175142Comparison of the Treatment Efficacy of Rosuvastatin versus Atorvastatin Loading Prior to Percutaneous Coronary Intervention in ST-Segment Elevation Myocardial InfarctionEsraa M. Adel0Ahmed A. Elberry1Ahmed Abdel Aziz2Ibrahim A. Naguib3Badrah S. Alghamdi4Raghda R. S. Hussein5National Heart Institute, Cairo 12461, EgyptDepartment of Pharmacy Practice, Pharmacy Program, Batterjee Medical College, Jeddah 21442, Saudi ArabiaNational Heart Institute, Cairo 12461, EgyptDepartment of Pharmaceutical Chemistry, College of Pharmacy, Taif University, Taif 21944, Saudi ArabiaNeuroscience Unit, Department of Physiology, Faculty of Medicine, King Abdulaziz University, Jeddah 22252, Saudi ArabiaDepartment of Clinical Pharmacy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, EgyptThe aim of this study was to compare the effect of a single high-dose rosuvastatin versus atorvastatin preloading in ST-elevation myocardial infarction (STEMI) patients receiving primary percutaneous coronary intervention (PCI.) Methods: A total of 99 patients presented with STEMI and were randomly divided into three groups—a control group (<i>n</i> = 33) with no statin treatment, an atorvastatin group (<i>n</i> = 33) with a single 80 mg atorvastatin dose and the rosuvastatin group (<i>n</i> = 33) with a single 40 mg rosuvastatin dose in the emergency room (ER) prior to PCI. Post-interventional thrombolysis in myocardial infarction (TIMI) flow grade and corrected TIMI frame count (CTFC) were recorded, and ST-segment resolution was measured. Results: CTFC was significantly lower for the atorvastatin group (<i>p</i>-value < 0.01) than in the control group. A final TIMI flow grade 3 was achieved in 32 (97.0%) patients in the rosuvastatin group and 28 (84.8%) patients in the atorvastatin group compared with only 25 (75.8%) patients in the control group (<i>p</i> = 0.014). Peak CK-MB in the rosuvastatin group (263.2 [207.2–315.6]) and the atorvastatin group (208 [151.0–314.1]) was lower compared to that in the control group (398.4 [303.9–459.3]); <i>p</i> < 0.001. Conclusions: A single extensive dose of lipophilic atorvastatin prior to primary PCI in STEMI patients showed better improvement in microvascular myocardial perfusion compared to hydrophilic rosuvastatin.https://www.mdpi.com/2077-0383/11/17/5142hydrophiliclipophilicatorvastatinrosuvastatinstatinSTEMI |
| spellingShingle | Esraa M. Adel Ahmed A. Elberry Ahmed Abdel Aziz Ibrahim A. Naguib Badrah S. Alghamdi Raghda R. S. Hussein Comparison of the Treatment Efficacy of Rosuvastatin versus Atorvastatin Loading Prior to Percutaneous Coronary Intervention in ST-Segment Elevation Myocardial Infarction Journal of Clinical Medicine hydrophilic lipophilic atorvastatin rosuvastatin statin STEMI |
| title | Comparison of the Treatment Efficacy of Rosuvastatin versus Atorvastatin Loading Prior to Percutaneous Coronary Intervention in ST-Segment Elevation Myocardial Infarction |
| title_full | Comparison of the Treatment Efficacy of Rosuvastatin versus Atorvastatin Loading Prior to Percutaneous Coronary Intervention in ST-Segment Elevation Myocardial Infarction |
| title_fullStr | Comparison of the Treatment Efficacy of Rosuvastatin versus Atorvastatin Loading Prior to Percutaneous Coronary Intervention in ST-Segment Elevation Myocardial Infarction |
| title_full_unstemmed | Comparison of the Treatment Efficacy of Rosuvastatin versus Atorvastatin Loading Prior to Percutaneous Coronary Intervention in ST-Segment Elevation Myocardial Infarction |
| title_short | Comparison of the Treatment Efficacy of Rosuvastatin versus Atorvastatin Loading Prior to Percutaneous Coronary Intervention in ST-Segment Elevation Myocardial Infarction |
| title_sort | comparison of the treatment efficacy of rosuvastatin versus atorvastatin loading prior to percutaneous coronary intervention in st segment elevation myocardial infarction |
| topic | hydrophilic lipophilic atorvastatin rosuvastatin statin STEMI |
| url | https://www.mdpi.com/2077-0383/11/17/5142 |
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