Case Report: Clinicopathological Analysis of Minute Pulmonary Meningothelial-Like Nodules: Report of 7 Cases
ObjectiveTo investigate the clinical manifestations, radiologic features, pathological features, and immunophenotype of minute pulmonary meningothelial-like nodules (MPMNs).MethodThis is a retrospective observational study. We collected the clinical data of 7 cases of MPMNs, and performed comprehens...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-07-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.942517/full |
| _version_ | 1811218701140099072 |
|---|---|
| author | Ying-xia Wang Zi Lei Man Yang Zhi-yuan Wang Xuan Zhang Guo-qing Pan |
| author_facet | Ying-xia Wang Zi Lei Man Yang Zhi-yuan Wang Xuan Zhang Guo-qing Pan |
| author_sort | Ying-xia Wang |
| collection | DOAJ |
| description | ObjectiveTo investigate the clinical manifestations, radiologic features, pathological features, and immunophenotype of minute pulmonary meningothelial-like nodules (MPMNs).MethodThis is a retrospective observational study. We collected the clinical data of 7 cases of MPMNs, and performed comprehensive characterization using a combination of clinical, morphological, radiologic and immunohistochemical assessments.ResultsOf the 7 cases of MPMNs, 6 were female and 1 was male. The median age was 55 years. All MPMNs were multiple in lung with the size from 0,01 to 0,5cm. Chest CT examination showed ground-glass attenuation or solid nodules. Four cases were concomitant with carcinoma and/or pneumonia, and 3 cases occurred alone. Four of the 7 patients had no obvious symptoms; 3 patients had chest pain or cough or shortness of breath or hemoptysis. Multiple white nodules were found macroscopically, and the diseased cells grew along the alveolar septum, with relatively normal morphology, rich cytoplasm, unclear cell boundary, and uniform nucleus with delicate chromatin and without atypia; and the diseased cells showed nest or whorls distribution. EMA, PR, CD56 and vimentin were positive in all cases by immunohistochemistry.ConclusionsMPMNs are rare benign lesions in the lung, often multiple, usually less than 0.5cm in diameter, most of which have no obvious clinical symptoms. MPMNs are often found by chest CT, and occur independently or concomitant with other lesions. The positive immunohistochemical staining of EMA, PR, CD56, vimentin supports the diagnosis. |
| first_indexed | 2024-04-12T07:13:46Z |
| format | Article |
| id | doaj.art-4ee1b6fa2a2147b391f6a37bbab32ffe |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-12T07:13:46Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-4ee1b6fa2a2147b391f6a37bbab32ffe2022-12-22T03:42:32ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-07-011210.3389/fonc.2022.942517942517Case Report: Clinicopathological Analysis of Minute Pulmonary Meningothelial-Like Nodules: Report of 7 CasesYing-xia Wang0Zi Lei1Man Yang2Zhi-yuan Wang3Xuan Zhang4Guo-qing Pan5Department of Pathology, The First Affiliated Hospital of Kunming Medical University, Kunming, ChinaDepartment of Pathology, The First Affiliated Hospital of Kunming Medical University, Kunming, ChinaDepartment of Pathology, Fuyuan County People’s Hospital of Qujing City, Fuyuan, ChinaDepartment of Pathology, The First Affiliated Hospital of Kunming Medical University, Kunming, ChinaSchool of Pharmaceutical Sciences and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, ChinaDepartment of Pathology, The First Affiliated Hospital of Kunming Medical University, Kunming, ChinaObjectiveTo investigate the clinical manifestations, radiologic features, pathological features, and immunophenotype of minute pulmonary meningothelial-like nodules (MPMNs).MethodThis is a retrospective observational study. We collected the clinical data of 7 cases of MPMNs, and performed comprehensive characterization using a combination of clinical, morphological, radiologic and immunohistochemical assessments.ResultsOf the 7 cases of MPMNs, 6 were female and 1 was male. The median age was 55 years. All MPMNs were multiple in lung with the size from 0,01 to 0,5cm. Chest CT examination showed ground-glass attenuation or solid nodules. Four cases were concomitant with carcinoma and/or pneumonia, and 3 cases occurred alone. Four of the 7 patients had no obvious symptoms; 3 patients had chest pain or cough or shortness of breath or hemoptysis. Multiple white nodules were found macroscopically, and the diseased cells grew along the alveolar septum, with relatively normal morphology, rich cytoplasm, unclear cell boundary, and uniform nucleus with delicate chromatin and without atypia; and the diseased cells showed nest or whorls distribution. EMA, PR, CD56 and vimentin were positive in all cases by immunohistochemistry.ConclusionsMPMNs are rare benign lesions in the lung, often multiple, usually less than 0.5cm in diameter, most of which have no obvious clinical symptoms. MPMNs are often found by chest CT, and occur independently or concomitant with other lesions. The positive immunohistochemical staining of EMA, PR, CD56, vimentin supports the diagnosis.https://www.frontiersin.org/articles/10.3389/fonc.2022.942517/fullminute pulmonary meningothelial-like nodulesbenign lesionspathological featuresimmunophenotyperadiographic manifestations |
| spellingShingle | Ying-xia Wang Zi Lei Man Yang Zhi-yuan Wang Xuan Zhang Guo-qing Pan Case Report: Clinicopathological Analysis of Minute Pulmonary Meningothelial-Like Nodules: Report of 7 Cases Frontiers in Oncology minute pulmonary meningothelial-like nodules benign lesions pathological features immunophenotype radiographic manifestations |
| title | Case Report: Clinicopathological Analysis of Minute Pulmonary Meningothelial-Like Nodules: Report of 7 Cases |
| title_full | Case Report: Clinicopathological Analysis of Minute Pulmonary Meningothelial-Like Nodules: Report of 7 Cases |
| title_fullStr | Case Report: Clinicopathological Analysis of Minute Pulmonary Meningothelial-Like Nodules: Report of 7 Cases |
| title_full_unstemmed | Case Report: Clinicopathological Analysis of Minute Pulmonary Meningothelial-Like Nodules: Report of 7 Cases |
| title_short | Case Report: Clinicopathological Analysis of Minute Pulmonary Meningothelial-Like Nodules: Report of 7 Cases |
| title_sort | case report clinicopathological analysis of minute pulmonary meningothelial like nodules report of 7 cases |
| topic | minute pulmonary meningothelial-like nodules benign lesions pathological features immunophenotype radiographic manifestations |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.942517/full |
| work_keys_str_mv | AT yingxiawang casereportclinicopathologicalanalysisofminutepulmonarymeningotheliallikenodulesreportof7cases AT zilei casereportclinicopathologicalanalysisofminutepulmonarymeningotheliallikenodulesreportof7cases AT manyang casereportclinicopathologicalanalysisofminutepulmonarymeningotheliallikenodulesreportof7cases AT zhiyuanwang casereportclinicopathologicalanalysisofminutepulmonarymeningotheliallikenodulesreportof7cases AT xuanzhang casereportclinicopathologicalanalysisofminutepulmonarymeningotheliallikenodulesreportof7cases AT guoqingpan casereportclinicopathologicalanalysisofminutepulmonarymeningotheliallikenodulesreportof7cases |