Cognitive impairment in cerebral small vessel disease induced by hypertension
Hypertension is a primary risk factor for the progression of cognitive impairment caused by cerebral small vessel disease, the most common cerebrovascular disease. However, the causal relationship between hypertension and cerebral small vessel disease remains unclear. Hypertension has substantial ne...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-01-01
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| Series: | Neural Regeneration Research |
| Subjects: | |
| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2024;volume=19;issue=7;spage=1454;epage=1462;aulast=Wei |
| _version_ | 1797231736301551616 |
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| author | Weipeng Wei Denglei Ma Lin Li Lan Zhang |
| author_facet | Weipeng Wei Denglei Ma Lin Li Lan Zhang |
| author_sort | Weipeng Wei |
| collection | DOAJ |
| description | Hypertension is a primary risk factor for the progression of cognitive impairment caused by cerebral small vessel disease, the most common cerebrovascular disease. However, the causal relationship between hypertension and cerebral small vessel disease remains unclear. Hypertension has substantial negative impacts on brain health and is recognized as a risk factor for cerebrovascular disease. Chronic hypertension and lifestyle factors are associated with risks for stroke and dementia, and cerebral small vessel disease can cause dementia and stroke. Hypertension is the main driver of cerebral small vessel disease, which changes the structure and function of cerebral vessels via various mechanisms and leads to lacunar infarction, leukoaraiosis, white matter lesions, and intracerebral hemorrhage, ultimately resulting in cognitive decline and demonstrating that the brain is the target organ of hypertension. This review updates our understanding of the pathogenesis of hypertension-induced cerebral small vessel disease and the resulting changes in brain structure and function and declines in cognitive ability. We also discuss drugs to treat cerebral small vessel disease and cognitive impairment. |
| first_indexed | 2024-04-24T15:49:07Z |
| format | Article |
| id | doaj.art-4ee361229c3a4709b16f89131866cae8 |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-04-24T15:49:07Z |
| publishDate | 2024-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-4ee361229c3a4709b16f89131866cae82024-04-01T13:06:10ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742024-01-011971454146210.4103/1673-5374.385841Cognitive impairment in cerebral small vessel disease induced by hypertensionWeipeng WeiDenglei MaLin LiLan ZhangHypertension is a primary risk factor for the progression of cognitive impairment caused by cerebral small vessel disease, the most common cerebrovascular disease. However, the causal relationship between hypertension and cerebral small vessel disease remains unclear. Hypertension has substantial negative impacts on brain health and is recognized as a risk factor for cerebrovascular disease. Chronic hypertension and lifestyle factors are associated with risks for stroke and dementia, and cerebral small vessel disease can cause dementia and stroke. Hypertension is the main driver of cerebral small vessel disease, which changes the structure and function of cerebral vessels via various mechanisms and leads to lacunar infarction, leukoaraiosis, white matter lesions, and intracerebral hemorrhage, ultimately resulting in cognitive decline and demonstrating that the brain is the target organ of hypertension. This review updates our understanding of the pathogenesis of hypertension-induced cerebral small vessel disease and the resulting changes in brain structure and function and declines in cognitive ability. We also discuss drugs to treat cerebral small vessel disease and cognitive impairment.http://www.nrronline.org/article.asp?issn=1673-5374;year=2024;volume=19;issue=7;spage=1454;epage=1462;aulast=Weiblood-brain barrier; cerebral small vessel disease; cognitive impairment; dementia; endothelial dysfunction; enlarged perivascular space; hypertension; lacunar infarction; neuroinflammation; treatment; white matter high signal intensity |
| spellingShingle | Weipeng Wei Denglei Ma Lin Li Lan Zhang Cognitive impairment in cerebral small vessel disease induced by hypertension Neural Regeneration Research blood-brain barrier; cerebral small vessel disease; cognitive impairment; dementia; endothelial dysfunction; enlarged perivascular space; hypertension; lacunar infarction; neuroinflammation; treatment; white matter high signal intensity |
| title | Cognitive impairment in cerebral small vessel disease induced by hypertension |
| title_full | Cognitive impairment in cerebral small vessel disease induced by hypertension |
| title_fullStr | Cognitive impairment in cerebral small vessel disease induced by hypertension |
| title_full_unstemmed | Cognitive impairment in cerebral small vessel disease induced by hypertension |
| title_short | Cognitive impairment in cerebral small vessel disease induced by hypertension |
| title_sort | cognitive impairment in cerebral small vessel disease induced by hypertension |
| topic | blood-brain barrier; cerebral small vessel disease; cognitive impairment; dementia; endothelial dysfunction; enlarged perivascular space; hypertension; lacunar infarction; neuroinflammation; treatment; white matter high signal intensity |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2024;volume=19;issue=7;spage=1454;epage=1462;aulast=Wei |
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