Investigation of Toxoplasma gondii Seroprevalence in Preeclampsic Pregnant
Objective: Toxoplasma gondii is the causative agent of toxoplasmosis and is a parasite of high medical importance with a wide host variety. Bacterial, viral, and parasitic infections during pregnancy may predispose women to pregnancy complications. Preeclampsia of unknown etiology causes special con...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2023-12-01
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| Series: | Türkiye Parazitoloji Dergisi |
| Subjects: | |
| Online Access: |
http://www.turkiyeparazitolderg.org/archives/archive-detail/article-preview/nvestigation-of-itoxoplasma-gondii-i-seroprevalenc/63998
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| _version_ | 1797372847326232576 |
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| author | Ayşenur Yıldırım Ahmet Duran Ataş |
| author_facet | Ayşenur Yıldırım Ahmet Duran Ataş |
| author_sort | Ayşenur Yıldırım |
| collection | DOAJ |
| description | Objective: Toxoplasma gondii is the causative agent of toxoplasmosis and is a parasite of high medical importance with a wide host variety. Bacterial, viral, and parasitic infections during pregnancy may predispose women to pregnancy complications. Preeclampsia of unknown etiology causes special conditions such as systemic vascular endothelial damage due to insufficient trophoblastic invasion and abnormal placentation. There are data of an association between various maternal infections and preeclampsia/eclampsias. The aim of the study was to compare and analyze the relationship between the presence of anti-Toxoplasma IgM and anti-Toxoplasma IgG antibodies in pregnant women with pre-eclampsia and in normotensive healthy pregnant women who were in the control group. Methods: In this study, 176 pregnant women who applied to our hospital between January 2019 and December 2020 were included. 88 (50%) of the pregnant women had pre-eclampsia and 88 (50%) were normotensive. The presence of anti-Toxoplasma IgM and IgG antibodies in blood taken from pregnant women with pre-eclampsia and control group was investigated using ELISA. Results: Because of the study, both groups were found to be seronegative in terms of anti-Toxoplasma IgM by ELISA. Anti-Toxoplasma IgG was found to be seropositive in 24 (27.3%) pregnant women with pre-eclampsia and 18 (20.5%) normotensive pregnant women. There was no statistically significant difference between the two groups in terms of anti-Toxoplasma IgM and anti-Toxoplasma IgG seropositivity (X2=0.289, p>0.05) (p<0.05). Conclusion: Because of the study, no statistically significant difference was found between pregnant women with pre-eclampsia and those with toxoplasmosis. It was thought that further studies should be conducted to discuss the hormonal, vascular, etc. factors occurring in the pathogenesis of preeclampsia of T. gondii effect of preparing the ground for the changes and to reveal the existence of a possible relationship between pre-eclampsia and T. gondii seropositivity. |
| first_indexed | 2024-03-08T18:41:44Z |
| format | Article |
| id | doaj.art-4ee628f2bf5d406597dc857255dcfb3f |
| institution | Directory Open Access Journal |
| issn | 2146-3077 |
| language | English |
| last_indexed | 2024-03-08T18:41:44Z |
| publishDate | 2023-12-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Türkiye Parazitoloji Dergisi |
| spelling | doaj.art-4ee628f2bf5d406597dc857255dcfb3f2023-12-29T06:00:28ZengGalenos YayineviTürkiye Parazitoloji Dergisi2146-30772023-12-0147420921310.4274/tpd.galenos.2023.8066413049054Investigation of Toxoplasma gondii Seroprevalence in Preeclampsic PregnantAyşenur Yıldırım0Ahmet Duran Ataş Sivas Cumhuriyet Üniversitesi, Sağlık Bilimleri Enstitüsü, Tıbbi Parazitoloji Anabilim Dalı, Sivas, Türkiye Objective: Toxoplasma gondii is the causative agent of toxoplasmosis and is a parasite of high medical importance with a wide host variety. Bacterial, viral, and parasitic infections during pregnancy may predispose women to pregnancy complications. Preeclampsia of unknown etiology causes special conditions such as systemic vascular endothelial damage due to insufficient trophoblastic invasion and abnormal placentation. There are data of an association between various maternal infections and preeclampsia/eclampsias. The aim of the study was to compare and analyze the relationship between the presence of anti-Toxoplasma IgM and anti-Toxoplasma IgG antibodies in pregnant women with pre-eclampsia and in normotensive healthy pregnant women who were in the control group. Methods: In this study, 176 pregnant women who applied to our hospital between January 2019 and December 2020 were included. 88 (50%) of the pregnant women had pre-eclampsia and 88 (50%) were normotensive. The presence of anti-Toxoplasma IgM and IgG antibodies in blood taken from pregnant women with pre-eclampsia and control group was investigated using ELISA. Results: Because of the study, both groups were found to be seronegative in terms of anti-Toxoplasma IgM by ELISA. Anti-Toxoplasma IgG was found to be seropositive in 24 (27.3%) pregnant women with pre-eclampsia and 18 (20.5%) normotensive pregnant women. There was no statistically significant difference between the two groups in terms of anti-Toxoplasma IgM and anti-Toxoplasma IgG seropositivity (X2=0.289, p>0.05) (p<0.05). Conclusion: Because of the study, no statistically significant difference was found between pregnant women with pre-eclampsia and those with toxoplasmosis. It was thought that further studies should be conducted to discuss the hormonal, vascular, etc. factors occurring in the pathogenesis of preeclampsia of T. gondii effect of preparing the ground for the changes and to reveal the existence of a possible relationship between pre-eclampsia and T. gondii seropositivity. http://www.turkiyeparazitolderg.org/archives/archive-detail/article-preview/nvestigation-of-itoxoplasma-gondii-i-seroprevalenc/63998 toxoplasma gondiipreeclampsiaelisaimmunoglobulin |
| spellingShingle | Ayşenur Yıldırım Ahmet Duran Ataş Investigation of Toxoplasma gondii Seroprevalence in Preeclampsic Pregnant Türkiye Parazitoloji Dergisi toxoplasma gondii preeclampsia elisa immunoglobulin |
| title | Investigation of Toxoplasma gondii Seroprevalence in Preeclampsic Pregnant |
| title_full | Investigation of Toxoplasma gondii Seroprevalence in Preeclampsic Pregnant |
| title_fullStr | Investigation of Toxoplasma gondii Seroprevalence in Preeclampsic Pregnant |
| title_full_unstemmed | Investigation of Toxoplasma gondii Seroprevalence in Preeclampsic Pregnant |
| title_short | Investigation of Toxoplasma gondii Seroprevalence in Preeclampsic Pregnant |
| title_sort | investigation of toxoplasma gondii seroprevalence in preeclampsic pregnant |
| topic | toxoplasma gondii preeclampsia elisa immunoglobulin |
| url |
http://www.turkiyeparazitolderg.org/archives/archive-detail/article-preview/nvestigation-of-itoxoplasma-gondii-i-seroprevalenc/63998
|
| work_keys_str_mv | AT aysenuryıldırım investigationoftoxoplasmagondiiseroprevalenceinpreeclampsicpregnant AT ahmetduranatas investigationoftoxoplasmagondiiseroprevalenceinpreeclampsicpregnant |