Low volume polyethylene glycol combined with senna versus high volume polyethylene glycol, which regimen is better for bowel preparation for colonoscopy? A randomized, controlled, and single‐blinded trial
Abstract Background and Aims Bowel preparation affects the quality of colonoscopy. Reaching the optimal preparation has been a challenge for years. Polyethylene glycol (PEG) is the sole FDA‐approved substance for this purpose. However, patients find it unpleasant and often complain about its adverse...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-09-01
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| Series: | Health Science Reports |
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| Online Access: | https://doi.org/10.1002/hsr2.829 |
| _version_ | 1797772383725027328 |
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| author | Amir Sadeghi Khaled Rahmani Pardis Ketabi Moghadam Saeed Abdi Ali Jahanian Mobin Fathy Mahsa Mohammadi Mehran Mahdavi Roshan Meysam Olfatifar Mohammad Reza Zali Mohammad Reza Hatamnejad Mohsen Rajabnia |
| author_facet | Amir Sadeghi Khaled Rahmani Pardis Ketabi Moghadam Saeed Abdi Ali Jahanian Mobin Fathy Mahsa Mohammadi Mehran Mahdavi Roshan Meysam Olfatifar Mohammad Reza Zali Mohammad Reza Hatamnejad Mohsen Rajabnia |
| author_sort | Amir Sadeghi |
| collection | DOAJ |
| description | Abstract Background and Aims Bowel preparation affects the quality of colonoscopy. Reaching the optimal preparation has been a challenge for years. Polyethylene glycol (PEG) is the sole FDA‐approved substance for this purpose. However, patients find it unpleasant and often complain about its adverse effects. In this study, we aimed to reduce these complaints by lowering the amount of PEG and adding senna which is an herbal stimulant laxative. Methods Four hundred and eighty‐six patients were admitted for colonoscopy. Finally, 382 patients were enrolled in the study and we divided them into two groups; 186 patients were placed in which conventional high volume PEG‐alone regimen was consumed and 196 patients in which low volume PEG plus senna regimen was offered. The quality of colon preparation was compared between the two groups by independent two samples t‐test (or its corresponding nonparametric test), Fisher's exact, or χ2 test in SPSS software version 22. Results The colon preparation quality was equally efficient in the two groups as 69.36% in the high volume PEG group and 71.94% in PEG plus senna group had adequate bowel preparation (p = 0.58). Adverse effects, like nausea, bloating, headache, and sleeplessness were significantly less in the low volume PEG plus senna group. Conclusion Besides the fact that bowel preparation by low volume PEG plus senna combination was noninferior to the conventional high volume PEG‐alone regimen, the side effects were much less common with the low volume PEG plus senna regimen. |
| first_indexed | 2024-03-12T21:50:04Z |
| format | Article |
| id | doaj.art-4ee6c6ad6f704c048e36eff4327e2a96 |
| institution | Directory Open Access Journal |
| issn | 2398-8835 |
| language | English |
| last_indexed | 2024-03-12T21:50:04Z |
| publishDate | 2022-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Health Science Reports |
| spelling | doaj.art-4ee6c6ad6f704c048e36eff4327e2a962023-07-26T04:11:54ZengWileyHealth Science Reports2398-88352022-09-0155n/an/a10.1002/hsr2.829Low volume polyethylene glycol combined with senna versus high volume polyethylene glycol, which regimen is better for bowel preparation for colonoscopy? A randomized, controlled, and single‐blinded trialAmir Sadeghi0Khaled Rahmani1Pardis Ketabi Moghadam2Saeed Abdi3Ali Jahanian4Mobin Fathy5Mahsa Mohammadi6Mehran Mahdavi Roshan7Meysam Olfatifar8Mohammad Reza Zali9Mohammad Reza Hatamnejad10Mohsen Rajabnia11Research Institute for Gastroenterology and Liver Diseases Shahid Beheshti University of Medical Science Tehran IranLiver and Digestive Research Center Kurdistan University of Medical Sciences Sanandaj IranResearch Institute for Gastroenterology and Liver Diseases Shahid Beheshti University of Medical Science Tehran IranResearch Institute for Gastroenterology and Liver Diseases Shahid Beheshti University of Medical Science Tehran IranResearch Institute for Gastroenterology and Liver Diseases Shahid Beheshti University of Medical Science Tehran IranResearch Institute for Gastroenterology and Liver Diseases Shahid Beheshti University of Medical Science Tehran IranResearch Institute for Gastroenterology and Liver Diseases Shahid Beheshti University of Medical Science Tehran IranResearch Institute for Gastroenterology and Liver Diseases Shahid Beheshti University of Medical Science Tehran IranGastroenterology and Hepataology Diseases Research Center Qom University of Medical Sciences Qom IranResearch Institute for Gastroenterology and Liver Diseases Shahid Beheshti University of Medical Science Tehran IranResearch Institute for Gastroenterology and Liver Diseases Shahid Beheshti University of Medical Science Tehran IranResearch Institute for Gastroenterology and Liver Diseases Shahid Beheshti University of Medical Science Tehran IranAbstract Background and Aims Bowel preparation affects the quality of colonoscopy. Reaching the optimal preparation has been a challenge for years. Polyethylene glycol (PEG) is the sole FDA‐approved substance for this purpose. However, patients find it unpleasant and often complain about its adverse effects. In this study, we aimed to reduce these complaints by lowering the amount of PEG and adding senna which is an herbal stimulant laxative. Methods Four hundred and eighty‐six patients were admitted for colonoscopy. Finally, 382 patients were enrolled in the study and we divided them into two groups; 186 patients were placed in which conventional high volume PEG‐alone regimen was consumed and 196 patients in which low volume PEG plus senna regimen was offered. The quality of colon preparation was compared between the two groups by independent two samples t‐test (or its corresponding nonparametric test), Fisher's exact, or χ2 test in SPSS software version 22. Results The colon preparation quality was equally efficient in the two groups as 69.36% in the high volume PEG group and 71.94% in PEG plus senna group had adequate bowel preparation (p = 0.58). Adverse effects, like nausea, bloating, headache, and sleeplessness were significantly less in the low volume PEG plus senna group. Conclusion Besides the fact that bowel preparation by low volume PEG plus senna combination was noninferior to the conventional high volume PEG‐alone regimen, the side effects were much less common with the low volume PEG plus senna regimen.https://doi.org/10.1002/hsr2.829bowel preparationcolonoscopylaxativespolyethylene glycolsennaside effects |
| spellingShingle | Amir Sadeghi Khaled Rahmani Pardis Ketabi Moghadam Saeed Abdi Ali Jahanian Mobin Fathy Mahsa Mohammadi Mehran Mahdavi Roshan Meysam Olfatifar Mohammad Reza Zali Mohammad Reza Hatamnejad Mohsen Rajabnia Low volume polyethylene glycol combined with senna versus high volume polyethylene glycol, which regimen is better for bowel preparation for colonoscopy? A randomized, controlled, and single‐blinded trial Health Science Reports bowel preparation colonoscopy laxatives polyethylene glycol senna side effects |
| title | Low volume polyethylene glycol combined with senna versus high volume polyethylene glycol, which regimen is better for bowel preparation for colonoscopy? A randomized, controlled, and single‐blinded trial |
| title_full | Low volume polyethylene glycol combined with senna versus high volume polyethylene glycol, which regimen is better for bowel preparation for colonoscopy? A randomized, controlled, and single‐blinded trial |
| title_fullStr | Low volume polyethylene glycol combined with senna versus high volume polyethylene glycol, which regimen is better for bowel preparation for colonoscopy? A randomized, controlled, and single‐blinded trial |
| title_full_unstemmed | Low volume polyethylene glycol combined with senna versus high volume polyethylene glycol, which regimen is better for bowel preparation for colonoscopy? A randomized, controlled, and single‐blinded trial |
| title_short | Low volume polyethylene glycol combined with senna versus high volume polyethylene glycol, which regimen is better for bowel preparation for colonoscopy? A randomized, controlled, and single‐blinded trial |
| title_sort | low volume polyethylene glycol combined with senna versus high volume polyethylene glycol which regimen is better for bowel preparation for colonoscopy a randomized controlled and single blinded trial |
| topic | bowel preparation colonoscopy laxatives polyethylene glycol senna side effects |
| url | https://doi.org/10.1002/hsr2.829 |
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