Mouse Models of Germinal Center Derived B-Cell Lymphomas
Over the last decades, the revolution in DNA sequencing has changed the way we understand the genetics and biology of B-cell lymphomas by uncovering a large number of recurrently mutated genes, whose aberrant function is likely to play an important role in the initiation and/or maintenance of these...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-08-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.710711/full |
| _version_ | 1818624104849211392 |
|---|---|
| author | Stefanie N. Meyer Sanjay Koul Laura Pasqualucci Laura Pasqualucci Laura Pasqualucci |
| author_facet | Stefanie N. Meyer Sanjay Koul Laura Pasqualucci Laura Pasqualucci Laura Pasqualucci |
| author_sort | Stefanie N. Meyer |
| collection | DOAJ |
| description | Over the last decades, the revolution in DNA sequencing has changed the way we understand the genetics and biology of B-cell lymphomas by uncovering a large number of recurrently mutated genes, whose aberrant function is likely to play an important role in the initiation and/or maintenance of these cancers. Dissecting how the involved genes contribute to the physiology and pathology of germinal center (GC) B cells –the origin of most B-cell lymphomas– will be key to advance our ability to diagnose and treat these patients. Genetically engineered mouse models (GEMM) that faithfully recapitulate lymphoma-associated genetic alterations offer a valuable platform to investigate the pathogenic roles of candidate oncogenes and tumor suppressors in vivo, and to pre-clinically develop new therapeutic principles in the context of an intact tumor immune microenvironment. In this review, we provide a summary of state-of-the art GEMMs obtained by accurately modelling the most common genetic alterations found in human GC B cell malignancies, with a focus on Burkitt lymphoma, follicular lymphoma, and diffuse large B-cell lymphoma, and we discuss how lessons learned from these models can help guide the design of novel therapeutic approaches for this disease. |
| first_indexed | 2024-12-16T18:51:39Z |
| format | Article |
| id | doaj.art-4ee7c9cdb77d45b4aa48944c67787c82 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-16T18:51:39Z |
| publishDate | 2021-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-4ee7c9cdb77d45b4aa48944c67787c822022-12-21T22:20:40ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-08-011210.3389/fimmu.2021.710711710711Mouse Models of Germinal Center Derived B-Cell LymphomasStefanie N. Meyer0Sanjay Koul1Laura Pasqualucci2Laura Pasqualucci3Laura Pasqualucci4Institute for Cancer Genetics, Columbia University, New York, NY, United StatesDepartment of Biological Sciences & Geology, Queensborough Community College (City University of New York), Bayside, NY, United StatesInstitute for Cancer Genetics, Columbia University, New York, NY, United StatesDepartment of Pathology & Cell Biology, Columbia University, New York, NY, United StatesThe Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, United StatesOver the last decades, the revolution in DNA sequencing has changed the way we understand the genetics and biology of B-cell lymphomas by uncovering a large number of recurrently mutated genes, whose aberrant function is likely to play an important role in the initiation and/or maintenance of these cancers. Dissecting how the involved genes contribute to the physiology and pathology of germinal center (GC) B cells –the origin of most B-cell lymphomas– will be key to advance our ability to diagnose and treat these patients. Genetically engineered mouse models (GEMM) that faithfully recapitulate lymphoma-associated genetic alterations offer a valuable platform to investigate the pathogenic roles of candidate oncogenes and tumor suppressors in vivo, and to pre-clinically develop new therapeutic principles in the context of an intact tumor immune microenvironment. In this review, we provide a summary of state-of-the art GEMMs obtained by accurately modelling the most common genetic alterations found in human GC B cell malignancies, with a focus on Burkitt lymphoma, follicular lymphoma, and diffuse large B-cell lymphoma, and we discuss how lessons learned from these models can help guide the design of novel therapeutic approaches for this disease.https://www.frontiersin.org/articles/10.3389/fimmu.2021.710711/fullgerminal centerlymphomageneticsmouse modelstransgenic |
| spellingShingle | Stefanie N. Meyer Sanjay Koul Laura Pasqualucci Laura Pasqualucci Laura Pasqualucci Mouse Models of Germinal Center Derived B-Cell Lymphomas Frontiers in Immunology germinal center lymphoma genetics mouse models transgenic |
| title | Mouse Models of Germinal Center Derived B-Cell Lymphomas |
| title_full | Mouse Models of Germinal Center Derived B-Cell Lymphomas |
| title_fullStr | Mouse Models of Germinal Center Derived B-Cell Lymphomas |
| title_full_unstemmed | Mouse Models of Germinal Center Derived B-Cell Lymphomas |
| title_short | Mouse Models of Germinal Center Derived B-Cell Lymphomas |
| title_sort | mouse models of germinal center derived b cell lymphomas |
| topic | germinal center lymphoma genetics mouse models transgenic |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.710711/full |
| work_keys_str_mv | AT stefanienmeyer mousemodelsofgerminalcenterderivedbcelllymphomas AT sanjaykoul mousemodelsofgerminalcenterderivedbcelllymphomas AT laurapasqualucci mousemodelsofgerminalcenterderivedbcelllymphomas AT laurapasqualucci mousemodelsofgerminalcenterderivedbcelllymphomas AT laurapasqualucci mousemodelsofgerminalcenterderivedbcelllymphomas |