Synthesis and Application of 4′-<i>C</i>-[(<i>N</i>-alkyl)aminoethyl]thymidine Analogs for Optimizing Oligonucleotide Properties

Synthesis and Application of 4′-<i>C</i>-[(<i>N</i>-alkyl)aminoethyl]thymidine Analogs for Optimizing Oligonucleotide Properties

Gapmer-type antisense oligonucleotides (ASOs) are an emerging class of therapeutic agents that directly inhibit pathogenic mRNA. In this study, three new 4′-<i>C</i>-substituted thymidine analogs were generated using a synthetic strategy recently established by our group, namely, 4′-<...

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Bibliographic Details
Main Authors: Kota Fujiki, Yuri Kakisawa, Elsayed M. Mahmoud, Yoshihito Ueno
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Molecules
Subjects:
antisense oligonucleotides
4′-aminoethyl modification
phosphorothioate
locked nucleic acid
nuclease resistance
RNase H
Online Access:https://www.mdpi.com/1420-3049/30/3/581

Internet

https://www.mdpi.com/1420-3049/30/3/581

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