Looking for the early marker of renal injury
Acute Kidney Injury is a complex and increasingly common syndrome. Practically all available markers reflect functional impairment rather than a true direct mark of cellular injury. An ideal AKI biomarker should be accurate, reliable, easy to measure with a standard assay, noninvasive, reproducible,...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2015-01-01
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| Series: | The Egyptian Journal of Internal Medicine |
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| Online Access: | http://www.esim.eg.net/article.asp?issn=1110-7782;year=2015;volume=27;issue=2;spage=45;epage=47;aulast=Zaky |
| _version_ | 1818995500989284352 |
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| author | Ahmed S.A. Zaky |
| author_facet | Ahmed S.A. Zaky |
| author_sort | Ahmed S.A. Zaky |
| collection | DOAJ |
| description | Acute Kidney Injury is a complex and increasingly common syndrome. Practically all available markers reflect functional impairment rather than a true direct mark of cellular injury. An ideal AKI biomarker should be accurate, reliable, easy to measure with a standard assay, noninvasive, reproducible, and sensitive and specific with defined cutoff values. Studies have identified a relatively small number of genes that are specifically altered in acute renal tubular injury. Kim-1 is one of the best-characterized urinary biomarkers to date in both experimental animals and humans with renal disease. Also NGAL is at the top of many researchers′ lists. Other biomarkers include IL-18, N-acetyl-β-d-glucosaminidase, and urinary liver-type fatty acid binding protein. |
| first_indexed | 2024-12-20T21:14:50Z |
| format | Article |
| id | doaj.art-4ee91200104e4d449cee23013db3b8b3 |
| institution | Directory Open Access Journal |
| issn | 1110-7782 2090-9098 |
| language | English |
| last_indexed | 2024-12-20T21:14:50Z |
| publishDate | 2015-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Internal Medicine |
| spelling | doaj.art-4ee91200104e4d449cee23013db3b8b32022-12-21T19:26:27ZengSpringerOpenThe Egyptian Journal of Internal Medicine1110-77822090-90982015-01-01272454710.4103/1110-7782.159446Looking for the early marker of renal injuryAhmed S.A. ZakyAcute Kidney Injury is a complex and increasingly common syndrome. Practically all available markers reflect functional impairment rather than a true direct mark of cellular injury. An ideal AKI biomarker should be accurate, reliable, easy to measure with a standard assay, noninvasive, reproducible, and sensitive and specific with defined cutoff values. Studies have identified a relatively small number of genes that are specifically altered in acute renal tubular injury. Kim-1 is one of the best-characterized urinary biomarkers to date in both experimental animals and humans with renal disease. Also NGAL is at the top of many researchers′ lists. Other biomarkers include IL-18, N-acetyl-β-d-glucosaminidase, and urinary liver-type fatty acid binding protein.http://www.esim.eg.net/article.asp?issn=1110-7782;year=2015;volume=27;issue=2;spage=45;epage=47;aulast=ZakyAKI, biomarkers, Kim-1, NGAL |
| spellingShingle | Ahmed S.A. Zaky Looking for the early marker of renal injury The Egyptian Journal of Internal Medicine AKI, biomarkers, Kim-1, NGAL |
| title | Looking for the early marker of renal injury |
| title_full | Looking for the early marker of renal injury |
| title_fullStr | Looking for the early marker of renal injury |
| title_full_unstemmed | Looking for the early marker of renal injury |
| title_short | Looking for the early marker of renal injury |
| title_sort | looking for the early marker of renal injury |
| topic | AKI, biomarkers, Kim-1, NGAL |
| url | http://www.esim.eg.net/article.asp?issn=1110-7782;year=2015;volume=27;issue=2;spage=45;epage=47;aulast=Zaky |
| work_keys_str_mv | AT ahmedsazaky lookingfortheearlymarkerofrenalinjury |