Prevalence and predictors for sustained remission in rheumatoid arthritis.
<h4>Objective</h4>Remission is a key goal in managing rheumatoid arthritis (RA), with sustained remission as the preferred sequelae of short-term remission. However little is known about the predictors of sustained remission for patients reaching remission. Using two independent cohorts,...
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2019-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0214981 |
| _version_ | 1829137943812374528 |
|---|---|
| author | Yoon-Kyoung Sung Kazuki Yoshida Femke H M Prince Michelle L Frits Soo-Kyung Cho Jung-Yoon Choe Hye-Soon Lee Jisoo Lee Shin-Seok Lee Dae-Hyun Yoo Simon M Helfgott Nancy A Shadick Michael E Weinblatt Daniel H Solomon Sang-Cheol Bae |
| author_facet | Yoon-Kyoung Sung Kazuki Yoshida Femke H M Prince Michelle L Frits Soo-Kyung Cho Jung-Yoon Choe Hye-Soon Lee Jisoo Lee Shin-Seok Lee Dae-Hyun Yoo Simon M Helfgott Nancy A Shadick Michael E Weinblatt Daniel H Solomon Sang-Cheol Bae |
| author_sort | Yoon-Kyoung Sung |
| collection | DOAJ |
| description | <h4>Objective</h4>Remission is a key goal in managing rheumatoid arthritis (RA), with sustained remission as the preferred sequelae of short-term remission. However little is known about the predictors of sustained remission for patients reaching remission. Using two independent cohorts, we aimed to evaluate the prevalence and predictors for sustained remission.<h4>Methods</h4>The study cohort consisted of subjects with RA from the Brigham and Women's Hospital Rheumatoid Arthritis Sequential Study (BRASS) and the Korean Observational Study Network for Arthritis (KORONA). We analyzed subjects who reached remission in 2009 with follow up data for two consecutive years. Remission was defined by the Disease Activity Score 28- (DAS28-CRP) of less than 2.6. Sustained remission was defined as three consecutive annual visits in remission. Predictors for sustained remission were identified by multivariate logistic regression analysis.<h4>Results</h4>A total of 465 subjects were in remission in 2009. Sustained remission was achieved by 53 of 92 (57.5%) in BRASS and by 198 of 373 (53.1%) in KORONA. In multivariate analyses, baseline predictors of sustained remission were: disease duration less than 5 years [odds ratio (OR) 1.96, 95% confidence interval (95% CI) 1.08-3.58], Modified Health Assessment Questionnaire (MHAQ) score of 0 (OR 1.80, 95% CI 1.18-2.74), and non-use of oral glucocorticoid (OR 1.58, 95% CI 1.01-2.47).<h4>Conclusion</h4>More than half of RA subjects in remission in 2009 remained in remission through 2011. Short disease duration, no disability, and non-use of oral glucocorticoid at baseline were associated with sustained remission. |
| first_indexed | 2024-12-14T19:07:40Z |
| format | Article |
| id | doaj.art-4eeb01db7e2c49c59eaa562fa546b04d |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-14T19:07:40Z |
| publishDate | 2019-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-4eeb01db7e2c49c59eaa562fa546b04d2022-12-21T22:50:48ZengPublic Library of Science (PLoS)PLoS ONE1932-62032019-01-01144e021498110.1371/journal.pone.0214981Prevalence and predictors for sustained remission in rheumatoid arthritis.Yoon-Kyoung SungKazuki YoshidaFemke H M PrinceMichelle L FritsSoo-Kyung ChoJung-Yoon ChoeHye-Soon LeeJisoo LeeShin-Seok LeeDae-Hyun YooSimon M HelfgottNancy A ShadickMichael E WeinblattDaniel H SolomonSang-Cheol Bae<h4>Objective</h4>Remission is a key goal in managing rheumatoid arthritis (RA), with sustained remission as the preferred sequelae of short-term remission. However little is known about the predictors of sustained remission for patients reaching remission. Using two independent cohorts, we aimed to evaluate the prevalence and predictors for sustained remission.<h4>Methods</h4>The study cohort consisted of subjects with RA from the Brigham and Women's Hospital Rheumatoid Arthritis Sequential Study (BRASS) and the Korean Observational Study Network for Arthritis (KORONA). We analyzed subjects who reached remission in 2009 with follow up data for two consecutive years. Remission was defined by the Disease Activity Score 28- (DAS28-CRP) of less than 2.6. Sustained remission was defined as three consecutive annual visits in remission. Predictors for sustained remission were identified by multivariate logistic regression analysis.<h4>Results</h4>A total of 465 subjects were in remission in 2009. Sustained remission was achieved by 53 of 92 (57.5%) in BRASS and by 198 of 373 (53.1%) in KORONA. In multivariate analyses, baseline predictors of sustained remission were: disease duration less than 5 years [odds ratio (OR) 1.96, 95% confidence interval (95% CI) 1.08-3.58], Modified Health Assessment Questionnaire (MHAQ) score of 0 (OR 1.80, 95% CI 1.18-2.74), and non-use of oral glucocorticoid (OR 1.58, 95% CI 1.01-2.47).<h4>Conclusion</h4>More than half of RA subjects in remission in 2009 remained in remission through 2011. Short disease duration, no disability, and non-use of oral glucocorticoid at baseline were associated with sustained remission.https://doi.org/10.1371/journal.pone.0214981 |
| spellingShingle | Yoon-Kyoung Sung Kazuki Yoshida Femke H M Prince Michelle L Frits Soo-Kyung Cho Jung-Yoon Choe Hye-Soon Lee Jisoo Lee Shin-Seok Lee Dae-Hyun Yoo Simon M Helfgott Nancy A Shadick Michael E Weinblatt Daniel H Solomon Sang-Cheol Bae Prevalence and predictors for sustained remission in rheumatoid arthritis. PLoS ONE |
| title | Prevalence and predictors for sustained remission in rheumatoid arthritis. |
| title_full | Prevalence and predictors for sustained remission in rheumatoid arthritis. |
| title_fullStr | Prevalence and predictors for sustained remission in rheumatoid arthritis. |
| title_full_unstemmed | Prevalence and predictors for sustained remission in rheumatoid arthritis. |
| title_short | Prevalence and predictors for sustained remission in rheumatoid arthritis. |
| title_sort | prevalence and predictors for sustained remission in rheumatoid arthritis |
| url | https://doi.org/10.1371/journal.pone.0214981 |
| work_keys_str_mv | AT yoonkyoungsung prevalenceandpredictorsforsustainedremissioninrheumatoidarthritis AT kazukiyoshida prevalenceandpredictorsforsustainedremissioninrheumatoidarthritis AT femkehmprince prevalenceandpredictorsforsustainedremissioninrheumatoidarthritis AT michellelfrits prevalenceandpredictorsforsustainedremissioninrheumatoidarthritis AT sookyungcho prevalenceandpredictorsforsustainedremissioninrheumatoidarthritis AT jungyoonchoe prevalenceandpredictorsforsustainedremissioninrheumatoidarthritis AT hyesoonlee prevalenceandpredictorsforsustainedremissioninrheumatoidarthritis AT jisoolee prevalenceandpredictorsforsustainedremissioninrheumatoidarthritis AT shinseoklee prevalenceandpredictorsforsustainedremissioninrheumatoidarthritis AT daehyunyoo prevalenceandpredictorsforsustainedremissioninrheumatoidarthritis AT simonmhelfgott prevalenceandpredictorsforsustainedremissioninrheumatoidarthritis AT nancyashadick prevalenceandpredictorsforsustainedremissioninrheumatoidarthritis AT michaeleweinblatt prevalenceandpredictorsforsustainedremissioninrheumatoidarthritis AT danielhsolomon prevalenceandpredictorsforsustainedremissioninrheumatoidarthritis AT sangcheolbae prevalenceandpredictorsforsustainedremissioninrheumatoidarthritis |