The impact of time length to Boolean remission for tight disease activity control after acquisition in rheumatoid arthritis patients
Abstract Clinical importance of time length from initiation under treat-to-target (T2T) strategy to acquisition of clinical remission (TL) in treating patients with rheumatoid arthritis (RA) on disease activity control, daily activities, and quality of life maintenance was investigated. In patients...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-08-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-39711-4 |
| _version_ | 1797560109747929088 |
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| author | Ichiro Yoshii Tatsumi Chijiwa Naoya Sawada |
| author_facet | Ichiro Yoshii Tatsumi Chijiwa Naoya Sawada |
| author_sort | Ichiro Yoshii |
| collection | DOAJ |
| description | Abstract Clinical importance of time length from initiation under treat-to-target (T2T) strategy to acquisition of clinical remission (TL) in treating patients with rheumatoid arthritis (RA) on disease activity control, daily activities, and quality of life maintenance was investigated. In patients who achieved Boolean remission once or more, relationship between TL and patients’ background data at initiation, and relationship between TL and mean simplified disease activity score (SDAI), Health Assessment Questionnaire Disability Index (HAQ-DI) score, pain score with visual analog scale (PS-VAS), Sharp/van der Heijde Score (SHS) and quality of life score (QOLS) at the first remission and thereafter were evaluated statistically. Patients were divided into two groups whether TL was within 6 months or longer (G ≤ 6 and G > 6). Change of the parameters and Boolean remission rate (BRR) after the first remission between the two groups were compared statistically. In 465 patients, TL correlated significantly with the SDAI score, the HAQ score, PS-VAS, SHS, and the QOLS after the remission. The SDAI score and the BRR after the remission were significantly better in the G ≤ 6 than in the G > 6. TL is an important key to guarantee good and stable clinical course in treating under T2T. |
| first_indexed | 2024-03-10T17:54:45Z |
| format | Article |
| id | doaj.art-4eeb77f0b9c3444996dec6754cf2e65d |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-10T17:54:45Z |
| publishDate | 2023-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-4eeb77f0b9c3444996dec6754cf2e65d2023-11-20T09:13:28ZengNature PortfolioScientific Reports2045-23222023-08-0113111310.1038/s41598-023-39711-4The impact of time length to Boolean remission for tight disease activity control after acquisition in rheumatoid arthritis patientsIchiro Yoshii0Tatsumi Chijiwa1Naoya Sawada2Department of Rheumatology and Musculoskeletal Medicine, Yoshii HospitalDepartment of Rheumatology, Kochi Memorial HospitalDepartment of Rheumatology, Dohgo Onsen HospitalAbstract Clinical importance of time length from initiation under treat-to-target (T2T) strategy to acquisition of clinical remission (TL) in treating patients with rheumatoid arthritis (RA) on disease activity control, daily activities, and quality of life maintenance was investigated. In patients who achieved Boolean remission once or more, relationship between TL and patients’ background data at initiation, and relationship between TL and mean simplified disease activity score (SDAI), Health Assessment Questionnaire Disability Index (HAQ-DI) score, pain score with visual analog scale (PS-VAS), Sharp/van der Heijde Score (SHS) and quality of life score (QOLS) at the first remission and thereafter were evaluated statistically. Patients were divided into two groups whether TL was within 6 months or longer (G ≤ 6 and G > 6). Change of the parameters and Boolean remission rate (BRR) after the first remission between the two groups were compared statistically. In 465 patients, TL correlated significantly with the SDAI score, the HAQ score, PS-VAS, SHS, and the QOLS after the remission. The SDAI score and the BRR after the remission were significantly better in the G ≤ 6 than in the G > 6. TL is an important key to guarantee good and stable clinical course in treating under T2T.https://doi.org/10.1038/s41598-023-39711-4 |
| spellingShingle | Ichiro Yoshii Tatsumi Chijiwa Naoya Sawada The impact of time length to Boolean remission for tight disease activity control after acquisition in rheumatoid arthritis patients Scientific Reports |
| title | The impact of time length to Boolean remission for tight disease activity control after acquisition in rheumatoid arthritis patients |
| title_full | The impact of time length to Boolean remission for tight disease activity control after acquisition in rheumatoid arthritis patients |
| title_fullStr | The impact of time length to Boolean remission for tight disease activity control after acquisition in rheumatoid arthritis patients |
| title_full_unstemmed | The impact of time length to Boolean remission for tight disease activity control after acquisition in rheumatoid arthritis patients |
| title_short | The impact of time length to Boolean remission for tight disease activity control after acquisition in rheumatoid arthritis patients |
| title_sort | impact of time length to boolean remission for tight disease activity control after acquisition in rheumatoid arthritis patients |
| url | https://doi.org/10.1038/s41598-023-39711-4 |
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