Primary failure of eruption (PFE): a systematic review
Abstract Background Primary failure of eruption (PFE) is a rare disease defined as incomplete tooth eruption despite the presence of a clear eruption pathway. Orthodontic extrusion is not feasible in this case because it results in ankylosis of teeth. To the best of our knowledge, besides the study...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2018-03-01
|
| Series: | Head & Face Medicine |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13005-018-0163-7 |
| _version_ | 1828742387537543168 |
|---|---|
| author | Marcel Hanisch Lale Hanisch Johannes Kleinheinz Susanne Jung |
| author_facet | Marcel Hanisch Lale Hanisch Johannes Kleinheinz Susanne Jung |
| author_sort | Marcel Hanisch |
| collection | DOAJ |
| description | Abstract Background Primary failure of eruption (PFE) is a rare disease defined as incomplete tooth eruption despite the presence of a clear eruption pathway. Orthodontic extrusion is not feasible in this case because it results in ankylosis of teeth. To the best of our knowledge, besides the study of Ahmad et al. (Eur J Orthod 28:535-540, 2006), no study has systematically analysed the clinical features of and factors associated with PFE. Therefore, the aim of this study was to systematically evaluate the current literature (from 2006 to 2017) for new insights and developments on the aetiology, diagnosis, genetics, and treatment options of PFE. Methods Following the PRISMA guidelines, a systematic search was performed using the PubMed/Medline database for studies reporting on PFE. The following terms were used: “primary failure of tooth eruption”, “primary failure of eruption”, “tooth eruption failure”, and “PFE”. Results Overall, 17 articles reporting clinical data of 314 patients were identified. In all patients, the molars were affected. In 81 reported cases, both the molars and the premolars were affected by PFE. Further, 38 patients’ primary teeth were also affected. In 27 patients, no family members were affected. Additional dental anomalies were observed in 39 patients. A total of 51 different variants of the PTH1R gene associated with PFE were recorded. Conclusions Infraocclusion of the posterior teeth, especially if both sides are affected, is the hallmark of PFE. If a patient is affected by PFE, all teeth distal to the most mesial tooth are also affected by PFE. Primary teeth can also be impacted; however, this may not necessarily occur. If a patient is suspected of having PFE, a genetic test for mutation in the PTH1R gene should be recommended prior to any orthodontic treatment to avoid ankylosis. Treatment options depend on the patient’s age and the clinical situation, and they must be evaluated individually. |
| first_indexed | 2024-04-13T01:18:35Z |
| format | Article |
| id | doaj.art-4eecffa6cf2244648692cad62d7d6e6a |
| institution | Directory Open Access Journal |
| issn | 1746-160X |
| language | English |
| last_indexed | 2024-04-13T01:18:35Z |
| publishDate | 2018-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Head & Face Medicine |
| spelling | doaj.art-4eecffa6cf2244648692cad62d7d6e6a2022-12-22T03:08:50ZengBMCHead & Face Medicine1746-160X2018-03-011411910.1186/s13005-018-0163-7Primary failure of eruption (PFE): a systematic reviewMarcel Hanisch0Lale Hanisch1Johannes Kleinheinz2Susanne Jung3Department of Cranio-Maxillofacial Surgery, Research Unit Rare Diseases with Orofacial Manifestations (RDOM), University Hospital MünsterDepartment of Orthodontics, Faculty of Health, School of Dentistry, Witten/Herdecke UniversityDepartment of Cranio-Maxillofacial Surgery, Research Unit Rare Diseases with Orofacial Manifestations (RDOM), University Hospital MünsterDepartment of Cranio-Maxillofacial Surgery, Research Unit Rare Diseases with Orofacial Manifestations (RDOM), University Hospital MünsterAbstract Background Primary failure of eruption (PFE) is a rare disease defined as incomplete tooth eruption despite the presence of a clear eruption pathway. Orthodontic extrusion is not feasible in this case because it results in ankylosis of teeth. To the best of our knowledge, besides the study of Ahmad et al. (Eur J Orthod 28:535-540, 2006), no study has systematically analysed the clinical features of and factors associated with PFE. Therefore, the aim of this study was to systematically evaluate the current literature (from 2006 to 2017) for new insights and developments on the aetiology, diagnosis, genetics, and treatment options of PFE. Methods Following the PRISMA guidelines, a systematic search was performed using the PubMed/Medline database for studies reporting on PFE. The following terms were used: “primary failure of tooth eruption”, “primary failure of eruption”, “tooth eruption failure”, and “PFE”. Results Overall, 17 articles reporting clinical data of 314 patients were identified. In all patients, the molars were affected. In 81 reported cases, both the molars and the premolars were affected by PFE. Further, 38 patients’ primary teeth were also affected. In 27 patients, no family members were affected. Additional dental anomalies were observed in 39 patients. A total of 51 different variants of the PTH1R gene associated with PFE were recorded. Conclusions Infraocclusion of the posterior teeth, especially if both sides are affected, is the hallmark of PFE. If a patient is affected by PFE, all teeth distal to the most mesial tooth are also affected by PFE. Primary teeth can also be impacted; however, this may not necessarily occur. If a patient is suspected of having PFE, a genetic test for mutation in the PTH1R gene should be recommended prior to any orthodontic treatment to avoid ankylosis. Treatment options depend on the patient’s age and the clinical situation, and they must be evaluated individually.http://link.springer.com/article/10.1186/s13005-018-0163-7Eruption disorderOrthodonticsPFEPrimary failure of eruptionPTH1RRare diseases |
| spellingShingle | Marcel Hanisch Lale Hanisch Johannes Kleinheinz Susanne Jung Primary failure of eruption (PFE): a systematic review Head & Face Medicine Eruption disorder Orthodontics PFE Primary failure of eruption PTH1R Rare diseases |
| title | Primary failure of eruption (PFE): a systematic review |
| title_full | Primary failure of eruption (PFE): a systematic review |
| title_fullStr | Primary failure of eruption (PFE): a systematic review |
| title_full_unstemmed | Primary failure of eruption (PFE): a systematic review |
| title_short | Primary failure of eruption (PFE): a systematic review |
| title_sort | primary failure of eruption pfe a systematic review |
| topic | Eruption disorder Orthodontics PFE Primary failure of eruption PTH1R Rare diseases |
| url | http://link.springer.com/article/10.1186/s13005-018-0163-7 |
| work_keys_str_mv | AT marcelhanisch primaryfailureoferuptionpfeasystematicreview AT lalehanisch primaryfailureoferuptionpfeasystematicreview AT johanneskleinheinz primaryfailureoferuptionpfeasystematicreview AT susannejung primaryfailureoferuptionpfeasystematicreview |