Generic Pharmaceuticals as a Source of Diuretic Contamination in Athletes Subject to Sport Drug Testing
This paper describes nine instances of positive anti-doping tests that could be accounted for by the use of permitted generic prescription drugs contaminated with diuretics, which are prohibited in sport at all times under the WADA Prohibited List. The contamination levels found in the medications a...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-11-01
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| Series: | Frontiers in Sports and Active Living |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fspor.2021.692244/full |
| _version_ | 1818750902546202624 |
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| author | Amy Eichner Laura A. Lewis Bridget Leonard Ryan M. Van Wagoner Daniel Eichner Matthew N. Fedoruk |
| author_facet | Amy Eichner Laura A. Lewis Bridget Leonard Ryan M. Van Wagoner Daniel Eichner Matthew N. Fedoruk |
| author_sort | Amy Eichner |
| collection | DOAJ |
| description | This paper describes nine instances of positive anti-doping tests that could be accounted for by the use of permitted generic prescription drugs contaminated with diuretics, which are prohibited in sport at all times under the WADA Prohibited List. The contamination levels found in the medications are reported and were below FDA limits for manufacturers that are based primarily on safety considerations. These cases demonstrate that great care must be taken to identify the source of low-level anti-doping positives for diuretics reported by WADA-accredited laboratories, and possibly other prohibited substances as well, in order to avoid sanctioning innocent athletes. An evaluation of the cases in this paper supports an approach which establishes a laboratory minimum reporting level (MRL) for diuretics found most commonly in medications. A global consensus after extensive review of similar anti-doping cases has resulted in implementation of a recently announced solution regarding potential diuretic contamination cases. |
| first_indexed | 2024-12-18T04:27:03Z |
| format | Article |
| id | doaj.art-4eef0f70092f49fe8daacc537daa353a |
| institution | Directory Open Access Journal |
| issn | 2624-9367 |
| language | English |
| last_indexed | 2024-12-18T04:27:03Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Sports and Active Living |
| spelling | doaj.art-4eef0f70092f49fe8daacc537daa353a2022-12-21T21:21:04ZengFrontiers Media S.A.Frontiers in Sports and Active Living2624-93672021-11-01310.3389/fspor.2021.692244692244Generic Pharmaceuticals as a Source of Diuretic Contamination in Athletes Subject to Sport Drug TestingAmy Eichner0Laura A. Lewis1Bridget Leonard2Ryan M. Van Wagoner3Daniel Eichner4Matthew N. Fedoruk5United States Anti-Doping Agency, Colorado Springs, CO, United StatesUnited States Anti-Doping Agency, Colorado Springs, CO, United StatesUnited States Anti-Doping Agency, Colorado Springs, CO, United StatesSports Medicine and Research Testing Laboratory, Salt Lake City, UT, United StatesSports Medicine and Research Testing Laboratory, Salt Lake City, UT, United StatesUnited States Anti-Doping Agency, Colorado Springs, CO, United StatesThis paper describes nine instances of positive anti-doping tests that could be accounted for by the use of permitted generic prescription drugs contaminated with diuretics, which are prohibited in sport at all times under the WADA Prohibited List. The contamination levels found in the medications are reported and were below FDA limits for manufacturers that are based primarily on safety considerations. These cases demonstrate that great care must be taken to identify the source of low-level anti-doping positives for diuretics reported by WADA-accredited laboratories, and possibly other prohibited substances as well, in order to avoid sanctioning innocent athletes. An evaluation of the cases in this paper supports an approach which establishes a laboratory minimum reporting level (MRL) for diuretics found most commonly in medications. A global consensus after extensive review of similar anti-doping cases has resulted in implementation of a recently announced solution regarding potential diuretic contamination cases.https://www.frontiersin.org/articles/10.3389/fspor.2021.692244/fullprescription medicationanti-dopingrule violationminimum reporting leveladverse analytical finding |
| spellingShingle | Amy Eichner Laura A. Lewis Bridget Leonard Ryan M. Van Wagoner Daniel Eichner Matthew N. Fedoruk Generic Pharmaceuticals as a Source of Diuretic Contamination in Athletes Subject to Sport Drug Testing Frontiers in Sports and Active Living prescription medication anti-doping rule violation minimum reporting level adverse analytical finding |
| title | Generic Pharmaceuticals as a Source of Diuretic Contamination in Athletes Subject to Sport Drug Testing |
| title_full | Generic Pharmaceuticals as a Source of Diuretic Contamination in Athletes Subject to Sport Drug Testing |
| title_fullStr | Generic Pharmaceuticals as a Source of Diuretic Contamination in Athletes Subject to Sport Drug Testing |
| title_full_unstemmed | Generic Pharmaceuticals as a Source of Diuretic Contamination in Athletes Subject to Sport Drug Testing |
| title_short | Generic Pharmaceuticals as a Source of Diuretic Contamination in Athletes Subject to Sport Drug Testing |
| title_sort | generic pharmaceuticals as a source of diuretic contamination in athletes subject to sport drug testing |
| topic | prescription medication anti-doping rule violation minimum reporting level adverse analytical finding |
| url | https://www.frontiersin.org/articles/10.3389/fspor.2021.692244/full |
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