Exploring the Impact of Endometrioma Aspiration and Dienogest Combination Therapy on Cyst Size, Inflammatory Cytokines in Follicular Fluid and Fertility Outcomes
Endometriomas (chocolate cysts) are cystic lesions that can develop on ovaries, and are characterized by the presence of ectopic endometrial tissue or similar tissue. Such lesions can cause a decline in the number and quality of oocytes, and lead to implantation failure. In this study, we retrospect...
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MDPI AG
2023-08-01
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| Series: | International Journal of Molecular Sciences |
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| author | Mamoru Shigeta Isao Tsuji Shu Hashimoto Udayanga Sanath Kankanam Gamage Masaya Yamanaka Aisaku Fukuda Yoshiharu Morimoto Daisuke Tachibana |
| author_facet | Mamoru Shigeta Isao Tsuji Shu Hashimoto Udayanga Sanath Kankanam Gamage Masaya Yamanaka Aisaku Fukuda Yoshiharu Morimoto Daisuke Tachibana |
| author_sort | Mamoru Shigeta |
| collection | DOAJ |
| description | Endometriomas (chocolate cysts) are cystic lesions that can develop on ovaries, and are characterized by the presence of ectopic endometrial tissue or similar tissue. Such lesions can cause a decline in the number and quality of oocytes, and lead to implantation failure. In this study, we retrospectively assessed the efficacy of repeated endometrioma aspiration and dienogest combination therapy in patients suffering endometriosis-associated infertility with endometriomas. A comparison was made between a treated group that underwent combination therapy followed by controlled ovarian hyperstimulation (COH) (<i>n</i> = 30) and a control group that did not undergo treatment (<i>n</i> = 40), at the IVF Osaka Clinic from September 2019 to September 2021. There were no differences in patient background between the two groups. A reduction in endometrioma size continued for 12 months after treatment. The numbers of follicles that developed to 15 mm or greater in size following COH and mature oocytes were significantly lower in the treated group compared to those in the control group. The levels of inflammatory cytokines in the follicular fluid significantly decreased in the treated group (<i>p</i> < 0.05). In patients in the treated group who underwent a second ova retrieval, the results were compared between those in the first ova retrieval (immediately after the end of treatment) and those in the second ova retrieval (four months after the first retrieval). The numbers of follicles following COH, retrieved, mature and fertilized ova were significantly increased in the second ova retrieval. |
| first_indexed | 2024-03-10T23:52:18Z |
| format | Article |
| id | doaj.art-4ef1ce1cfebf4028a64d7d1c89a66c96 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T23:52:18Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-4ef1ce1cfebf4028a64d7d1c89a66c962023-11-19T01:31:38ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-08-0124161289110.3390/ijms241612891Exploring the Impact of Endometrioma Aspiration and Dienogest Combination Therapy on Cyst Size, Inflammatory Cytokines in Follicular Fluid and Fertility OutcomesMamoru Shigeta0Isao Tsuji1Shu Hashimoto2Udayanga Sanath Kankanam Gamage3Masaya Yamanaka4Aisaku Fukuda5Yoshiharu Morimoto6Daisuke Tachibana7IVF Osaka Clinic, Higashi-Osaka, Osaka 577-0012, JapanIVF Osaka Clinic, Higashi-Osaka, Osaka 577-0012, JapanGraduate School of Medicine, Osaka Metropolitan University, Osaka 545-8585, JapanHORAC Grand Front Osaka Clinic, Osaka 530-0011, JapanHORAC Grand Front Osaka Clinic, Osaka 530-0011, JapanIVF Osaka Clinic, Higashi-Osaka, Osaka 577-0012, JapanHORAC Grand Front Osaka Clinic, Osaka 530-0011, JapanWomen’s Lifecare Medicine, Obstetrics and Gynecology, School of Medicine, Osaka Metropolitan University, Osaka 545-8585, JapanEndometriomas (chocolate cysts) are cystic lesions that can develop on ovaries, and are characterized by the presence of ectopic endometrial tissue or similar tissue. Such lesions can cause a decline in the number and quality of oocytes, and lead to implantation failure. In this study, we retrospectively assessed the efficacy of repeated endometrioma aspiration and dienogest combination therapy in patients suffering endometriosis-associated infertility with endometriomas. A comparison was made between a treated group that underwent combination therapy followed by controlled ovarian hyperstimulation (COH) (<i>n</i> = 30) and a control group that did not undergo treatment (<i>n</i> = 40), at the IVF Osaka Clinic from September 2019 to September 2021. There were no differences in patient background between the two groups. A reduction in endometrioma size continued for 12 months after treatment. The numbers of follicles that developed to 15 mm or greater in size following COH and mature oocytes were significantly lower in the treated group compared to those in the control group. The levels of inflammatory cytokines in the follicular fluid significantly decreased in the treated group (<i>p</i> < 0.05). In patients in the treated group who underwent a second ova retrieval, the results were compared between those in the first ova retrieval (immediately after the end of treatment) and those in the second ova retrieval (four months after the first retrieval). The numbers of follicles following COH, retrieved, mature and fertilized ova were significantly increased in the second ova retrieval.https://www.mdpi.com/1422-0067/24/16/12891endometriosisdienogestcytokinesendometrioma aspirationcontrolled ovarian stimulation |
| spellingShingle | Mamoru Shigeta Isao Tsuji Shu Hashimoto Udayanga Sanath Kankanam Gamage Masaya Yamanaka Aisaku Fukuda Yoshiharu Morimoto Daisuke Tachibana Exploring the Impact of Endometrioma Aspiration and Dienogest Combination Therapy on Cyst Size, Inflammatory Cytokines in Follicular Fluid and Fertility Outcomes International Journal of Molecular Sciences endometriosis dienogest cytokines endometrioma aspiration controlled ovarian stimulation |
| title | Exploring the Impact of Endometrioma Aspiration and Dienogest Combination Therapy on Cyst Size, Inflammatory Cytokines in Follicular Fluid and Fertility Outcomes |
| title_full | Exploring the Impact of Endometrioma Aspiration and Dienogest Combination Therapy on Cyst Size, Inflammatory Cytokines in Follicular Fluid and Fertility Outcomes |
| title_fullStr | Exploring the Impact of Endometrioma Aspiration and Dienogest Combination Therapy on Cyst Size, Inflammatory Cytokines in Follicular Fluid and Fertility Outcomes |
| title_full_unstemmed | Exploring the Impact of Endometrioma Aspiration and Dienogest Combination Therapy on Cyst Size, Inflammatory Cytokines in Follicular Fluid and Fertility Outcomes |
| title_short | Exploring the Impact of Endometrioma Aspiration and Dienogest Combination Therapy on Cyst Size, Inflammatory Cytokines in Follicular Fluid and Fertility Outcomes |
| title_sort | exploring the impact of endometrioma aspiration and dienogest combination therapy on cyst size inflammatory cytokines in follicular fluid and fertility outcomes |
| topic | endometriosis dienogest cytokines endometrioma aspiration controlled ovarian stimulation |
| url | https://www.mdpi.com/1422-0067/24/16/12891 |
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