Prevalence and Clinicopathologic Features of Canine Metastatic Melanoma Involving the Central Nervous System: A Retrospective Analysis and Comparative Review

Prevalence and Clinicopathologic Features of Canine Metastatic Melanoma Involving the Central Nervous System: A Retrospective Analysis and Comparative Review

BackgroundCentral nervous system (CNS) involvement is the leading cause of death in malignant melanoma. Rodent models, while vital to mechanistic investigation, have had limited success identifying effective therapies for melanoma brain metastases. The companion dog with de novo melanoma is a promis...

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Bibliographic Details
Main Authors: Aryana M. Razmara, Luke A. Wittenburg, Sami Al-Nadaf, Ryan G. Toedebusch, Frederick J. Meyers, Christine M. Toedebusch
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Oncology
Subjects:
malignant melanoma
central nervous system
canine
brain
seizure
large-animal model
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.868004/full

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