4237 TL1 Team Approach to Peripartum Obsessive-Compulsive Disorder: a meta-analysis of the perceived impact of gestation and delivery on symptomology
OBJECTIVES/GOALS: Obsessive compulsive disorder (OCD) is a serious and impairing disorder. The peripartum is associated with changes in pre-existing OCD, including exacerbation and improvement of the disorder. This meta-analysis seeks to understand the proportion of women reporting a change in OCD d...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2020-06-01
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| Series: | Journal of Clinical and Translational Science |
| Online Access: | https://www.cambridge.org/core/product/identifier/S2059866120001545/type/journal_article |
| _version_ | 1811155093791178752 |
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| author | Danielle Laine Cooke Rebecca Henderson Joseph McNamara Carol Mathews |
| author_facet | Danielle Laine Cooke Rebecca Henderson Joseph McNamara Carol Mathews |
| author_sort | Danielle Laine Cooke |
| collection | DOAJ |
| description | OBJECTIVES/GOALS: Obsessive compulsive disorder (OCD) is a serious and impairing disorder. The peripartum is associated with changes in pre-existing OCD, including exacerbation and improvement of the disorder. This meta-analysis seeks to understand the proportion of women reporting a change in OCD during this time. METHODS/STUDY POPULATION: Nine studies with independent samples examining change in obsessive-compulsive symptomology (OCS) in the peripartum were included in the meta-analysis. Studies were included if the sample examined with women with a clinical diagnosis of OCD that pre-existed pregnancy onset. The meta-analysis was conducted using R Studio with Meta, Metafor and Weightr packages. A moderation analysis was conducted to examine the impact of gestational period on OCD symptoms. Gestational periods were defined as pregnancy, postpartum, or the peripartum. Peripartum refers to a collapsed postpartum/pregnant period such that the period was not identified or specified during data collection. RESULTS/ANTICIPATED RESULTS: The summary proportion of women who experienced no change in symptoms was 46.7% (CI: 42.0-51.4%). No change by period was: pregnancy 49.6% (CI: 36.3-62.9%); postpartum 45.6% (CI: 41.4-49.9%); peripartum 52.4% (CI: 42.4-50.3%). The summary proportion of women who experienced exacerbation was 39.2% (CI: 33.5-45.5%). Exacerbation by period: pregnancy 35.5% (CI: 24.8-47.9%); postpartum 42.9% (CI: 34.8-51.4%); peripartum 34.6% (CI: 23.7-47.4%). The summary proportion of women who experienced improvement was 11.5% (CI: 9.3-14.4%). Improvement by period: pregnancy 42.9% (CI: 14.7-77.0%); postpartum 7.8% (CI: 5.7-10.4%); peripartum 19.6% (CI: 13.7-27.3%). Gestational period had a moderating effect. DISCUSSION/SIGNIFICANCE OF IMPACT: During the peripartum 46% report no change, 40% a worsening and 12% an improvement. Improvement typically occurs during pregnancy and may be followed by a postpartum worsening. This may reflect a hormonally-sensitive subsection of women impacted by the acute changes that occur during this time. |
| first_indexed | 2024-04-10T04:28:25Z |
| format | Article |
| id | doaj.art-4ef5a2d4463c4d08a6d5e4be34e3f431 |
| institution | Directory Open Access Journal |
| issn | 2059-8661 |
| language | English |
| last_indexed | 2024-04-10T04:28:25Z |
| publishDate | 2020-06-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Journal of Clinical and Translational Science |
| spelling | doaj.art-4ef5a2d4463c4d08a6d5e4be34e3f4312023-03-10T08:51:35ZengCambridge University PressJournal of Clinical and Translational Science2059-86612020-06-014404010.1017/cts.2020.1544237 TL1 Team Approach to Peripartum Obsessive-Compulsive Disorder: a meta-analysis of the perceived impact of gestation and delivery on symptomologyDanielle Laine Cooke0Rebecca Henderson1Joseph McNamara2Carol Mathews3University Of Florida Clinical and Translational Science InstituteUniversity Of Florida Clinical and Translational Science InstituteUniversity of Florida, College of MedicineUniversity of Florida, College of MedicineOBJECTIVES/GOALS: Obsessive compulsive disorder (OCD) is a serious and impairing disorder. The peripartum is associated with changes in pre-existing OCD, including exacerbation and improvement of the disorder. This meta-analysis seeks to understand the proportion of women reporting a change in OCD during this time. METHODS/STUDY POPULATION: Nine studies with independent samples examining change in obsessive-compulsive symptomology (OCS) in the peripartum were included in the meta-analysis. Studies were included if the sample examined with women with a clinical diagnosis of OCD that pre-existed pregnancy onset. The meta-analysis was conducted using R Studio with Meta, Metafor and Weightr packages. A moderation analysis was conducted to examine the impact of gestational period on OCD symptoms. Gestational periods were defined as pregnancy, postpartum, or the peripartum. Peripartum refers to a collapsed postpartum/pregnant period such that the period was not identified or specified during data collection. RESULTS/ANTICIPATED RESULTS: The summary proportion of women who experienced no change in symptoms was 46.7% (CI: 42.0-51.4%). No change by period was: pregnancy 49.6% (CI: 36.3-62.9%); postpartum 45.6% (CI: 41.4-49.9%); peripartum 52.4% (CI: 42.4-50.3%). The summary proportion of women who experienced exacerbation was 39.2% (CI: 33.5-45.5%). Exacerbation by period: pregnancy 35.5% (CI: 24.8-47.9%); postpartum 42.9% (CI: 34.8-51.4%); peripartum 34.6% (CI: 23.7-47.4%). The summary proportion of women who experienced improvement was 11.5% (CI: 9.3-14.4%). Improvement by period: pregnancy 42.9% (CI: 14.7-77.0%); postpartum 7.8% (CI: 5.7-10.4%); peripartum 19.6% (CI: 13.7-27.3%). Gestational period had a moderating effect. DISCUSSION/SIGNIFICANCE OF IMPACT: During the peripartum 46% report no change, 40% a worsening and 12% an improvement. Improvement typically occurs during pregnancy and may be followed by a postpartum worsening. This may reflect a hormonally-sensitive subsection of women impacted by the acute changes that occur during this time.https://www.cambridge.org/core/product/identifier/S2059866120001545/type/journal_article |
| spellingShingle | Danielle Laine Cooke Rebecca Henderson Joseph McNamara Carol Mathews 4237 TL1 Team Approach to Peripartum Obsessive-Compulsive Disorder: a meta-analysis of the perceived impact of gestation and delivery on symptomology Journal of Clinical and Translational Science |
| title | 4237 TL1 Team Approach to Peripartum Obsessive-Compulsive Disorder: a meta-analysis of the perceived impact of gestation and delivery on symptomology |
| title_full | 4237 TL1 Team Approach to Peripartum Obsessive-Compulsive Disorder: a meta-analysis of the perceived impact of gestation and delivery on symptomology |
| title_fullStr | 4237 TL1 Team Approach to Peripartum Obsessive-Compulsive Disorder: a meta-analysis of the perceived impact of gestation and delivery on symptomology |
| title_full_unstemmed | 4237 TL1 Team Approach to Peripartum Obsessive-Compulsive Disorder: a meta-analysis of the perceived impact of gestation and delivery on symptomology |
| title_short | 4237 TL1 Team Approach to Peripartum Obsessive-Compulsive Disorder: a meta-analysis of the perceived impact of gestation and delivery on symptomology |
| title_sort | 4237 tl1 team approach to peripartum obsessive compulsive disorder a meta analysis of the perceived impact of gestation and delivery on symptomology |
| url | https://www.cambridge.org/core/product/identifier/S2059866120001545/type/journal_article |
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