Polydopamine-activated celastrol carbon dots for synergistic chemotherapy-photothermal therapy of tumors
Synergistic chemotherapy and photothermal therapy (PTT) holds the promise of addressing the weakness of individualized chemotherapy and PTT. In this study, we synthesized a chemotherapeutic agent, PDA-Ce-CDs, which combines the photothermal conversion ability and the generation of hydroxyl radicals...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-12-01
|
| Series: | International Journal of Pharmaceutics: X |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590156723000622 |
| _version_ | 1827764830532009984 |
|---|---|
| author | Ping Sheng Chao Bu Tanyue Hui Lili Zhou Hao Chen Guoliang Zhou |
| author_facet | Ping Sheng Chao Bu Tanyue Hui Lili Zhou Hao Chen Guoliang Zhou |
| author_sort | Ping Sheng |
| collection | DOAJ |
| description | Synergistic chemotherapy and photothermal therapy (PTT) holds the promise of addressing the weakness of individualized chemotherapy and PTT. In this study, we synthesized a chemotherapeutic agent, PDA-Ce-CDs, which combines the photothermal conversion ability and the generation of hydroxyl radicals (•OH), enabling synergistic enhancement of antitumor effects. Furthermore, the localized heating effect of NIR radiation promoted the uptake of the PDA-Ce-CDs and enhances the sensitivity of intracellular reactive oxygen species (ROS). Finally, the antitumor activity of the PDA-Ce-CDs was evaluated through cell experiments and tumor-bearing mice experiments, confirming its excellent antitumor efficacy in vivo and in vitro. Our work presents a new strategy in cancer treatment by utilizing carbon dots in combination with photothermal agents for synergistic chemotherapy-photothermal therapy. This innovative approach offers a new therapeutic avenue for synergistic tumor treatment by harnessing the combined effects of photothermal therapy and chemotherapy. |
| first_indexed | 2024-03-11T11:10:27Z |
| format | Article |
| id | doaj.art-4ef7d1407d82400bb9c8e39043c5b86e |
| institution | Directory Open Access Journal |
| issn | 2590-1567 |
| language | English |
| last_indexed | 2024-03-11T11:10:27Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Pharmaceutics: X |
| spelling | doaj.art-4ef7d1407d82400bb9c8e39043c5b86e2023-11-12T04:40:54ZengElsevierInternational Journal of Pharmaceutics: X2590-15672023-12-016100218Polydopamine-activated celastrol carbon dots for synergistic chemotherapy-photothermal therapy of tumorsPing Sheng0Chao Bu1Tanyue Hui2Lili Zhou3Hao Chen4Guoliang Zhou5College of life and Health Sciences, Anhui Science and Technology University, Fengyang, 233100, ChinaCollege of life and Health Sciences, Anhui Science and Technology University, Fengyang, 233100, ChinaCollege of life and Health Sciences, Anhui Science and Technology University, Fengyang, 233100, ChinaCollege of life and Health Sciences, Anhui Science and Technology University, Fengyang, 233100, ChinaCorresponding authors.; College of life and Health Sciences, Anhui Science and Technology University, Fengyang, 233100, ChinaCorresponding authors.; College of life and Health Sciences, Anhui Science and Technology University, Fengyang, 233100, ChinaSynergistic chemotherapy and photothermal therapy (PTT) holds the promise of addressing the weakness of individualized chemotherapy and PTT. In this study, we synthesized a chemotherapeutic agent, PDA-Ce-CDs, which combines the photothermal conversion ability and the generation of hydroxyl radicals (•OH), enabling synergistic enhancement of antitumor effects. Furthermore, the localized heating effect of NIR radiation promoted the uptake of the PDA-Ce-CDs and enhances the sensitivity of intracellular reactive oxygen species (ROS). Finally, the antitumor activity of the PDA-Ce-CDs was evaluated through cell experiments and tumor-bearing mice experiments, confirming its excellent antitumor efficacy in vivo and in vitro. Our work presents a new strategy in cancer treatment by utilizing carbon dots in combination with photothermal agents for synergistic chemotherapy-photothermal therapy. This innovative approach offers a new therapeutic avenue for synergistic tumor treatment by harnessing the combined effects of photothermal therapy and chemotherapy.http://www.sciencedirect.com/science/article/pii/S2590156723000622PolydopamineCelastrol carbon dotsCarbon dots combined polydopamineChemotherapy-photothermal synergistic therapy |
| spellingShingle | Ping Sheng Chao Bu Tanyue Hui Lili Zhou Hao Chen Guoliang Zhou Polydopamine-activated celastrol carbon dots for synergistic chemotherapy-photothermal therapy of tumors International Journal of Pharmaceutics: X Polydopamine Celastrol carbon dots Carbon dots combined polydopamine Chemotherapy-photothermal synergistic therapy |
| title | Polydopamine-activated celastrol carbon dots for synergistic chemotherapy-photothermal therapy of tumors |
| title_full | Polydopamine-activated celastrol carbon dots for synergistic chemotherapy-photothermal therapy of tumors |
| title_fullStr | Polydopamine-activated celastrol carbon dots for synergistic chemotherapy-photothermal therapy of tumors |
| title_full_unstemmed | Polydopamine-activated celastrol carbon dots for synergistic chemotherapy-photothermal therapy of tumors |
| title_short | Polydopamine-activated celastrol carbon dots for synergistic chemotherapy-photothermal therapy of tumors |
| title_sort | polydopamine activated celastrol carbon dots for synergistic chemotherapy photothermal therapy of tumors |
| topic | Polydopamine Celastrol carbon dots Carbon dots combined polydopamine Chemotherapy-photothermal synergistic therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2590156723000622 |
| work_keys_str_mv | AT pingsheng polydopamineactivatedcelastrolcarbondotsforsynergisticchemotherapyphotothermaltherapyoftumors AT chaobu polydopamineactivatedcelastrolcarbondotsforsynergisticchemotherapyphotothermaltherapyoftumors AT tanyuehui polydopamineactivatedcelastrolcarbondotsforsynergisticchemotherapyphotothermaltherapyoftumors AT lilizhou polydopamineactivatedcelastrolcarbondotsforsynergisticchemotherapyphotothermaltherapyoftumors AT haochen polydopamineactivatedcelastrolcarbondotsforsynergisticchemotherapyphotothermaltherapyoftumors AT guoliangzhou polydopamineactivatedcelastrolcarbondotsforsynergisticchemotherapyphotothermaltherapyoftumors |