Plant-Derived Extracellular Vesicles as Therapeutic Nanocarriers
Mammalian exosomes have emerged as a promising class of functional materials, inspiring novel applications as therapeutic vehicles and nutraceutical compounds. Despite this, their immunogenicity has been an issue of controversy within the scientific community. Although, exosome-like vesicles, innate...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/23/1/191 |
| _version_ | 1797498871598809088 |
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| author | Theodora Karamanidou Alexander Tsouknidas |
| author_facet | Theodora Karamanidou Alexander Tsouknidas |
| author_sort | Theodora Karamanidou |
| collection | DOAJ |
| description | Mammalian exosomes have emerged as a promising class of functional materials, inspiring novel applications as therapeutic vehicles and nutraceutical compounds. Despite this, their immunogenicity has been an issue of controversy within the scientific community. Although, exosome-like vesicles, innately formed in plants and inherent to eukaryotic cell-derived vesicles, could soothe most of the concerns, they are notably underutilized as therapeutic modalities. This review highlights all efforts published so far, on the use of plant-derived extracellular vesicles (EVs) as therapeutic delivery systems. A summary of the physicochemical characteristics of plant-derived EVs is provided along with their main biological composition and in vitro/in vivo evidence of their therapeutic efficacy provided where available. Despite only a hand full of clinical trials being underway, concerning these vesicles, they arguably possess significant potential as nanodelivery systems of natural origin. |
| first_indexed | 2024-03-10T03:39:30Z |
| format | Article |
| id | doaj.art-4ef8a6b58a3c428381b9308add638acb |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T03:39:30Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-4ef8a6b58a3c428381b9308add638acb2023-11-23T11:36:08ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-12-0123119110.3390/ijms23010191Plant-Derived Extracellular Vesicles as Therapeutic NanocarriersTheodora Karamanidou0Alexander Tsouknidas1Laboratory for Biomaterials and Computational Mechanics, Department of Mechanical Engineering, University of Western Macedonia, 50100 Kozani, GreeceLaboratory for Biomaterials and Computational Mechanics, Department of Mechanical Engineering, University of Western Macedonia, 50100 Kozani, GreeceMammalian exosomes have emerged as a promising class of functional materials, inspiring novel applications as therapeutic vehicles and nutraceutical compounds. Despite this, their immunogenicity has been an issue of controversy within the scientific community. Although, exosome-like vesicles, innately formed in plants and inherent to eukaryotic cell-derived vesicles, could soothe most of the concerns, they are notably underutilized as therapeutic modalities. This review highlights all efforts published so far, on the use of plant-derived extracellular vesicles (EVs) as therapeutic delivery systems. A summary of the physicochemical characteristics of plant-derived EVs is provided along with their main biological composition and in vitro/in vivo evidence of their therapeutic efficacy provided where available. Despite only a hand full of clinical trials being underway, concerning these vesicles, they arguably possess significant potential as nanodelivery systems of natural origin.https://www.mdpi.com/1422-0067/23/1/191nanovesiclesexosome-like vesiclesintercellular communicationcancer treatment |
| spellingShingle | Theodora Karamanidou Alexander Tsouknidas Plant-Derived Extracellular Vesicles as Therapeutic Nanocarriers International Journal of Molecular Sciences nanovesicles exosome-like vesicles intercellular communication cancer treatment |
| title | Plant-Derived Extracellular Vesicles as Therapeutic Nanocarriers |
| title_full | Plant-Derived Extracellular Vesicles as Therapeutic Nanocarriers |
| title_fullStr | Plant-Derived Extracellular Vesicles as Therapeutic Nanocarriers |
| title_full_unstemmed | Plant-Derived Extracellular Vesicles as Therapeutic Nanocarriers |
| title_short | Plant-Derived Extracellular Vesicles as Therapeutic Nanocarriers |
| title_sort | plant derived extracellular vesicles as therapeutic nanocarriers |
| topic | nanovesicles exosome-like vesicles intercellular communication cancer treatment |
| url | https://www.mdpi.com/1422-0067/23/1/191 |
| work_keys_str_mv | AT theodorakaramanidou plantderivedextracellularvesiclesastherapeuticnanocarriers AT alexandertsouknidas plantderivedextracellularvesiclesastherapeuticnanocarriers |