The multifactorial origins of respiratory morbidity in patients surviving neonatal repair of esophageal atresia
<br/>Esophageal atresia with or without tracheoesophageal fistula (EA±TEF) occurs in 1 out of every 3000 births. Current survival approaches 95% and research is therefore focused on morbidity and health-related quality of life issues. <br/>Up to 50% of neonates with EA±TEF have one or mo...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-05-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fped.2014.00039/full |
| _version_ | 1818157951738707968 |
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| author | Ana Catarina eFragoso Ana Catarina eFragoso Juan A. Tovar |
| author_facet | Ana Catarina eFragoso Ana Catarina eFragoso Juan A. Tovar |
| author_sort | Ana Catarina eFragoso |
| collection | DOAJ |
| description | <br/>Esophageal atresia with or without tracheoesophageal fistula (EA±TEF) occurs in 1 out of every 3000 births. Current survival approaches 95% and research is therefore focused on morbidity and health-related quality of life issues. <br/>Up to 50% of neonates with EA±TEF have one or more additional malformations including those of the respiratory tract that occur in a relatively high proportion of them and particularly of those with VACTERL association. Additionally, a significant proportion of survivors suffer abnormal pulmonary function and chronic respiratory tract disease. The present review summarizes the current knowledge about the nature of these symptoms in patients treated for EA±TEF, and explores the hypothesis that disturbed development and maturation of the respiratory tract could contribute to their pathogenesis.<br/> |
| first_indexed | 2024-12-11T15:22:21Z |
| format | Article |
| id | doaj.art-4efb7fe67a794eeaa39004df95e22bd7 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-12-11T15:22:21Z |
| publishDate | 2014-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-4efb7fe67a794eeaa39004df95e22bd72022-12-22T01:00:19ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602014-05-01210.3389/fped.2014.0003989641The multifactorial origins of respiratory morbidity in patients surviving neonatal repair of esophageal atresiaAna Catarina eFragoso0Ana Catarina eFragoso1Juan A. Tovar2Faculty of Medicine. University of PortoHospital Universitario La PazHospital Universitario La Paz<br/>Esophageal atresia with or without tracheoesophageal fistula (EA±TEF) occurs in 1 out of every 3000 births. Current survival approaches 95% and research is therefore focused on morbidity and health-related quality of life issues. <br/>Up to 50% of neonates with EA±TEF have one or more additional malformations including those of the respiratory tract that occur in a relatively high proportion of them and particularly of those with VACTERL association. Additionally, a significant proportion of survivors suffer abnormal pulmonary function and chronic respiratory tract disease. The present review summarizes the current knowledge about the nature of these symptoms in patients treated for EA±TEF, and explores the hypothesis that disturbed development and maturation of the respiratory tract could contribute to their pathogenesis.<br/>http://journal.frontiersin.org/Journal/10.3389/fped.2014.00039/fullLungdevelopmenthumanrodent modelsesophageal atresia; tracheoesophageal fistularespiratory tract disease |
| spellingShingle | Ana Catarina eFragoso Ana Catarina eFragoso Juan A. Tovar The multifactorial origins of respiratory morbidity in patients surviving neonatal repair of esophageal atresia Frontiers in Pediatrics Lung development human rodent models esophageal atresia; tracheoesophageal fistula respiratory tract disease |
| title | The multifactorial origins of respiratory morbidity in patients surviving neonatal repair of esophageal atresia |
| title_full | The multifactorial origins of respiratory morbidity in patients surviving neonatal repair of esophageal atresia |
| title_fullStr | The multifactorial origins of respiratory morbidity in patients surviving neonatal repair of esophageal atresia |
| title_full_unstemmed | The multifactorial origins of respiratory morbidity in patients surviving neonatal repair of esophageal atresia |
| title_short | The multifactorial origins of respiratory morbidity in patients surviving neonatal repair of esophageal atresia |
| title_sort | multifactorial origins of respiratory morbidity in patients surviving neonatal repair of esophageal atresia |
| topic | Lung development human rodent models esophageal atresia; tracheoesophageal fistula respiratory tract disease |
| url | http://journal.frontiersin.org/Journal/10.3389/fped.2014.00039/full |
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