Summary: | Objective
Resection of residual masses after chemoteraphy in patients with nonseminomatous
testicular cancer is recommended. In our study, we evaluated
the patients’ data underwent post chemotherapy retroperitoneal lymph node
dissection (PC-RPLND).
Materials and Methods
Patients with advanced staged tumors and Non-seminomatous germ cells
and having residual mass after chemotherapy whose tumor markers returned
to normal were selected in the study. Pre-chemotherapy mass size, postchemoterapy
mass size, decrease rate in the mass size, prognostic factors of
local tumor, International Germ Cell Collaborative Clasification (IGCCC) risk
groups, and teratoma existence in primary pathology, PC-RPLND pathologies
were compared for fibrozis, teratoma or viable tumor presence. In addition,
patients with and without intraoperative complications were compared in
terms of the same parameters. Comparisons were conducted using Statistical
Packages for the Social Sciences (SPSS) 16.0 and p<0.05 was considered
statistically significantResults
Twenty six patients were included in the study. Respectively 4 (15%) viable
tumors, 14 (54%) teratoma, 8 (31%) necrosis were observed in patients
after PC-RPLND. No significant differences were observed in PC-RPLND
pathology results in IGCCC risk groups depending on presence of teratoma
in primary tumor or existence of more than 50% embryonal carcinoma after
orchiectomy pathology. Teratoma in 6 of 8 patients with no decrease in the
mass rate and viable tumor in 2 patients were detected. More than 90%
reduction rate in the mass was detected in only one patient whose PC-RPLND
pathology result was necrosis.There were no significant variations between
complication developed and undeveloped patients in terms of mass size and
live tumor existence.
Conclusion
Our data is consistent with the current literature. The mass size decrease
rate, teratoma presence in orchiectomy material, IGCCC risk groups and local
prognostic factors are not accurate predictive factors in determining the PCRPLND
pathology
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