The Effects of Polyhexamethylene Biguanide (PHMB) and TLR Agonists Alone or as Polyplex Nanoparticles against <em>Leishmania infantum</em> Promastigotes and Amastigotes

The Effects of Polyhexamethylene Biguanide (PHMB) and TLR Agonists Alone or as Polyplex Nanoparticles against <em>Leishmania infantum</em> Promastigotes and Amastigotes

Dogs are the main reservoir for <i>Leishmania infantum,</i> manifesting from a subclinical to a fatal disease. Limited treatments are available, although new antiparasitics and immunomodulators are pursued. Polyhexamethylene biguanide (PHMB) has a broad antimicrobial spectrum, including...

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Bibliographic Details
Main Authors: Pamela Martínez-Orellana, Marta Baxarias, Liam Good, Laia Solano-Gallego
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Veterinary Sciences
Subjects:
TLR4 agonist
TLR9 agonist
PHMB
<i>Leishmania infantum</i>
canine
macrophages
Online Access:https://www.mdpi.com/2306-7381/7/4/179

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