Down Syndrome and COVID-19: A Perfect Storm?
People with Down syndrome show signs of chronic immune dysregulation, including a higher prevalence of autoimmune disorders, increased rates of hospitalization during respiratory viral infections, and higher mortality rates from pneumonia and sepsis. At the molecular and cellular levels, they show m...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-05-01
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| Series: | Cell Reports Medicine |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666379120300240 |
| _version_ | 1818210599387004928 |
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| author | Joaquin M. Espinosa |
| author_facet | Joaquin M. Espinosa |
| author_sort | Joaquin M. Espinosa |
| collection | DOAJ |
| description | People with Down syndrome show signs of chronic immune dysregulation, including a higher prevalence of autoimmune disorders, increased rates of hospitalization during respiratory viral infections, and higher mortality rates from pneumonia and sepsis. At the molecular and cellular levels, they show markers of chronic autoinflammation, including interferon hyperactivity, elevated levels of many inflammatory cytokines and chemokines, and changes in diverse immune cell types reminiscent of inflammatory conditions observed in the general population. However, the impact of this immune dysregulation in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and CoV disease of 2019 (COVID-19) remains unknown. This Perspective outlines why individuals with Down syndrome should be considered an at-risk population for severe COVID-19. Specifically, the immune dysregulation caused by trisomy 21 may result in an exacerbated cytokine release syndrome relative to that observed in the euploid population, thus justifying additional monitoring and specialized care for this vulnerable population. |
| first_indexed | 2024-12-12T05:19:10Z |
| format | Article |
| id | doaj.art-4efe79f12e6b4591aca97ff3ca9a7aef |
| institution | Directory Open Access Journal |
| issn | 2666-3791 |
| language | English |
| last_indexed | 2024-12-12T05:19:10Z |
| publishDate | 2020-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports Medicine |
| spelling | doaj.art-4efe79f12e6b4591aca97ff3ca9a7aef2022-12-22T00:36:40ZengElsevierCell Reports Medicine2666-37912020-05-0112100019Down Syndrome and COVID-19: A Perfect Storm?Joaquin M. Espinosa0Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; Department of Pharmacology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; Corresponding authorPeople with Down syndrome show signs of chronic immune dysregulation, including a higher prevalence of autoimmune disorders, increased rates of hospitalization during respiratory viral infections, and higher mortality rates from pneumonia and sepsis. At the molecular and cellular levels, they show markers of chronic autoinflammation, including interferon hyperactivity, elevated levels of many inflammatory cytokines and chemokines, and changes in diverse immune cell types reminiscent of inflammatory conditions observed in the general population. However, the impact of this immune dysregulation in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and CoV disease of 2019 (COVID-19) remains unknown. This Perspective outlines why individuals with Down syndrome should be considered an at-risk population for severe COVID-19. Specifically, the immune dysregulation caused by trisomy 21 may result in an exacerbated cytokine release syndrome relative to that observed in the euploid population, thus justifying additional monitoring and specialized care for this vulnerable population.http://www.sciencedirect.com/science/article/pii/S2666379120300240 |
| spellingShingle | Joaquin M. Espinosa Down Syndrome and COVID-19: A Perfect Storm? Cell Reports Medicine |
| title | Down Syndrome and COVID-19: A Perfect Storm? |
| title_full | Down Syndrome and COVID-19: A Perfect Storm? |
| title_fullStr | Down Syndrome and COVID-19: A Perfect Storm? |
| title_full_unstemmed | Down Syndrome and COVID-19: A Perfect Storm? |
| title_short | Down Syndrome and COVID-19: A Perfect Storm? |
| title_sort | down syndrome and covid 19 a perfect storm |
| url | http://www.sciencedirect.com/science/article/pii/S2666379120300240 |
| work_keys_str_mv | AT joaquinmespinosa downsyndromeandcovid19aperfectstorm |