Impact of Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor on Renal Function in Patient with Heart Failure
Hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor is a recently introduced oral agent to treat renal anemia, but its clinical implications on renal functioning in patients with heart failure remains unknown. We studied an 81-year-old man with heart failure with mildly reduced ejection f...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Journal of Cardiovascular Development and Disease |
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| Online Access: | https://www.mdpi.com/2308-3425/8/12/189 |
| _version_ | 1797503505937727488 |
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| author | Teruhiko Imamura Yohei Ueno Koichiro Kinugawa |
| author_facet | Teruhiko Imamura Yohei Ueno Koichiro Kinugawa |
| author_sort | Teruhiko Imamura |
| collection | DOAJ |
| description | Hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor is a recently introduced oral agent to treat renal anemia, but its clinical implications on renal functioning in patients with heart failure remains unknown. We studied an 81-year-old man with heart failure with mildly reduced ejection fraction, chronic kidney disease, and renal anemia. The seven-month HIF-PH inhibitor daprodustat treatment improved the hemoglobin level from 7.4 g/dL to 11.8 g/dL and estimated glomerular filtration ratio from 24 mL/min/1.73 m<sup>2</sup> to 35 mL/min/1.73 m<sup>2</sup> without any complications, including thromboembolic events. HIF-PH inhibitor might be a promising therapeutic tool to improve renal anemia and renal function in patients with heart failure, although large-scale studies are warranted to validate our findings. |
| first_indexed | 2024-03-10T03:51:37Z |
| format | Article |
| id | doaj.art-4f0001d1aff249d79313f80e65ca5129 |
| institution | Directory Open Access Journal |
| issn | 2308-3425 |
| language | English |
| last_indexed | 2024-03-10T03:51:37Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Cardiovascular Development and Disease |
| spelling | doaj.art-4f0001d1aff249d79313f80e65ca51292023-11-23T08:55:09ZengMDPI AGJournal of Cardiovascular Development and Disease2308-34252021-12-0181218910.3390/jcdd8120189Impact of Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor on Renal Function in Patient with Heart FailureTeruhiko Imamura0Yohei Ueno1Koichiro Kinugawa2The Second Department of Internal Medicine, University of Toyama, 2630 Sugitani Toyama, Toyama 930-0194, JapanThe Second Department of Internal Medicine, University of Toyama, 2630 Sugitani Toyama, Toyama 930-0194, JapanThe Second Department of Internal Medicine, University of Toyama, 2630 Sugitani Toyama, Toyama 930-0194, JapanHypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor is a recently introduced oral agent to treat renal anemia, but its clinical implications on renal functioning in patients with heart failure remains unknown. We studied an 81-year-old man with heart failure with mildly reduced ejection fraction, chronic kidney disease, and renal anemia. The seven-month HIF-PH inhibitor daprodustat treatment improved the hemoglobin level from 7.4 g/dL to 11.8 g/dL and estimated glomerular filtration ratio from 24 mL/min/1.73 m<sup>2</sup> to 35 mL/min/1.73 m<sup>2</sup> without any complications, including thromboembolic events. HIF-PH inhibitor might be a promising therapeutic tool to improve renal anemia and renal function in patients with heart failure, although large-scale studies are warranted to validate our findings.https://www.mdpi.com/2308-3425/8/12/189heart failurechronic kidney diseasekidney |
| spellingShingle | Teruhiko Imamura Yohei Ueno Koichiro Kinugawa Impact of Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor on Renal Function in Patient with Heart Failure Journal of Cardiovascular Development and Disease heart failure chronic kidney disease kidney |
| title | Impact of Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor on Renal Function in Patient with Heart Failure |
| title_full | Impact of Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor on Renal Function in Patient with Heart Failure |
| title_fullStr | Impact of Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor on Renal Function in Patient with Heart Failure |
| title_full_unstemmed | Impact of Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor on Renal Function in Patient with Heart Failure |
| title_short | Impact of Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor on Renal Function in Patient with Heart Failure |
| title_sort | impact of hypoxia inducible factor prolyl hydroxylase inhibitor on renal function in patient with heart failure |
| topic | heart failure chronic kidney disease kidney |
| url | https://www.mdpi.com/2308-3425/8/12/189 |
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