Tumor lysis syndrome – An overview and current perspective
Tumor lysis syndrome (TLS) is an oncological emergency where in spontaneous or treatment-induced cell death leads to a constellation of metabolic abnormalities that can result in potentially life threatening complications. It is characterized by hyperkalemia, hyperuricemia, hyperphosphatemia and hyp...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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KIMS Foundation and Research Center
2014-04-01
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| Series: | Journal of Medical and Scientific Research |
| Online Access: | http://jmsronline.com/article.aspx?ID=Tumor-lysis-syndrome |
| _version_ | 1811325169790091264 |
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| author | Piyush K Gangadhar |
| author_facet | Piyush K Gangadhar |
| author_sort | Piyush K |
| collection | DOAJ |
| description | Tumor lysis syndrome (TLS) is an oncological emergency where in spontaneous or treatment-induced cell death leads to a constellation of metabolic abnormalities that can result in potentially life threatening complications. It is characterized by hyperkalemia, hyperuricemia, hyperphosphatemia and hypocalcemia. Etiopathogenesis is related to spontaneous cell death of rapidly growing tumor or more commonly to administration of cytotoxic chemotherapy in patients with hematologic malignancies and less so with solid malignancies. The precise incidence of TLS is not known, and neither racial nor gender predilection exists. Approximately 18% of the patients who develop TLS die of its complications [1]. The cornerstone of the management of TLS includes knowledge of its causes, recognition of high-risk patients, vigilant monitoring and prompt initiation of appropriate preventive and therapeutic measures when indicated. |
| first_indexed | 2024-04-13T14:28:26Z |
| format | Article |
| id | doaj.art-4f0018cfaf3e43f19bb224db0aae923a |
| institution | Directory Open Access Journal |
| issn | 2321-1326 2394-112X |
| language | English |
| last_indexed | 2024-04-13T14:28:26Z |
| publishDate | 2014-04-01 |
| publisher | KIMS Foundation and Research Center |
| record_format | Article |
| series | Journal of Medical and Scientific Research |
| spelling | doaj.art-4f0018cfaf3e43f19bb224db0aae923a2022-12-22T02:43:16ZengKIMS Foundation and Research CenterJournal of Medical and Scientific Research2321-13262394-112X2014-04-012210911210.17727/JMSR.2014/2-019Tumor lysis syndrome – An overview and current perspectivePiyush K0Gangadhar1JainVajralaTumor lysis syndrome (TLS) is an oncological emergency where in spontaneous or treatment-induced cell death leads to a constellation of metabolic abnormalities that can result in potentially life threatening complications. It is characterized by hyperkalemia, hyperuricemia, hyperphosphatemia and hypocalcemia. Etiopathogenesis is related to spontaneous cell death of rapidly growing tumor or more commonly to administration of cytotoxic chemotherapy in patients with hematologic malignancies and less so with solid malignancies. The precise incidence of TLS is not known, and neither racial nor gender predilection exists. Approximately 18% of the patients who develop TLS die of its complications [1]. The cornerstone of the management of TLS includes knowledge of its causes, recognition of high-risk patients, vigilant monitoring and prompt initiation of appropriate preventive and therapeutic measures when indicated.http://jmsronline.com/article.aspx?ID=Tumor-lysis-syndrome |
| spellingShingle | Piyush K Gangadhar Tumor lysis syndrome – An overview and current perspective Journal of Medical and Scientific Research |
| title | Tumor lysis syndrome – An overview and current perspective |
| title_full | Tumor lysis syndrome – An overview and current perspective |
| title_fullStr | Tumor lysis syndrome – An overview and current perspective |
| title_full_unstemmed | Tumor lysis syndrome – An overview and current perspective |
| title_short | Tumor lysis syndrome – An overview and current perspective |
| title_sort | tumor lysis syndrome an overview and current perspective |
| url | http://jmsronline.com/article.aspx?ID=Tumor-lysis-syndrome |
| work_keys_str_mv | AT piyushk tumorlysissyndromeanoverviewandcurrentperspective AT gangadhar tumorlysissyndromeanoverviewandcurrentperspective |