Signal, Transduction, and the Hematopoietic Stem Cell
The hematopoietic stem cell (HSC) is a unique cell positioned highest in the hematopoietic hierarchical system. The HSC has the ability to stay in quiescence, to self-renew, or to differentiate and generate all lineages of blood cells. The path to be actualized is influenced by signals that derive f...
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| Format: | Article |
| Language: | English |
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Rambam Health Care Campus
2014-10-01
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| Series: | Rambam Maimonides Medical Journal |
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| Online Access: | http://rmmj.org.il/Pages/ArticleHTM.aspx?manuId=439 |
| _version_ | 1819073079924490240 |
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| author | Igal Louria-Haydon |
| author_facet | Igal Louria-Haydon |
| author_sort | Igal Louria-Haydon |
| collection | DOAJ |
| description | The hematopoietic stem cell (HSC) is a unique cell positioned highest in the hematopoietic hierarchical system. The HSC has the ability to stay in quiescence, to self-renew, or to differentiate and generate all lineages of blood cells. The path to be actualized is influenced by signals that derive from the cell’s microenvironment, which activate molecular pathways inside the cell. Signaling pathways are commonly organized through inducible protein–protein interactions, mediated by adaptor proteins that link activated receptors to cytoplasmic effectors. This review will focus on the signaling molecules and how they work in concert to determine the HSC’s fate. |
| first_indexed | 2024-12-21T17:47:55Z |
| format | Article |
| id | doaj.art-4f00520bd93249c6bb9f570d4f3793e7 |
| institution | Directory Open Access Journal |
| issn | 2076-9172 |
| language | English |
| last_indexed | 2024-12-21T17:47:55Z |
| publishDate | 2014-10-01 |
| publisher | Rambam Health Care Campus |
| record_format | Article |
| series | Rambam Maimonides Medical Journal |
| spelling | doaj.art-4f00520bd93249c6bb9f570d4f3793e72022-12-21T18:55:27ZengRambam Health Care CampusRambam Maimonides Medical Journal2076-91722014-10-0154e003310.5041/RMMJ.10167Signal, Transduction, and the Hematopoietic Stem CellIgal Louria-Haydon0Department of Hematology, Rambam Health Care Campus, Haifa, Israel and Department of Biotechnology, Hadassah Academic College, Jerusalem, IsraelThe hematopoietic stem cell (HSC) is a unique cell positioned highest in the hematopoietic hierarchical system. The HSC has the ability to stay in quiescence, to self-renew, or to differentiate and generate all lineages of blood cells. The path to be actualized is influenced by signals that derive from the cell’s microenvironment, which activate molecular pathways inside the cell. Signaling pathways are commonly organized through inducible protein–protein interactions, mediated by adaptor proteins that link activated receptors to cytoplasmic effectors. This review will focus on the signaling molecules and how they work in concert to determine the HSC’s fate.http://rmmj.org.il/Pages/ArticleHTM.aspx?manuId=439DifferentiationHSC communicationnicheself-renewalsignal transduction |
| spellingShingle | Igal Louria-Haydon Signal, Transduction, and the Hematopoietic Stem Cell Rambam Maimonides Medical Journal Differentiation HSC communication niche self-renewal signal transduction |
| title | Signal, Transduction, and the Hematopoietic Stem Cell |
| title_full | Signal, Transduction, and the Hematopoietic Stem Cell |
| title_fullStr | Signal, Transduction, and the Hematopoietic Stem Cell |
| title_full_unstemmed | Signal, Transduction, and the Hematopoietic Stem Cell |
| title_short | Signal, Transduction, and the Hematopoietic Stem Cell |
| title_sort | signal transduction and the hematopoietic stem cell |
| topic | Differentiation HSC communication niche self-renewal signal transduction |
| url | http://rmmj.org.il/Pages/ArticleHTM.aspx?manuId=439 |
| work_keys_str_mv | AT igallouriahaydon signaltransductionandthehematopoieticstemcell |