Determination of 11 Kinds of Organophosphorus Flame Retardants in Baby Rice Cereal by Ultra-high Performance Liquid Chromatography-tandem Mass Spectrometry
A method for the determination of 11 organophosphorus flame retardants in baby rice flour was established by ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). The samples were extracted by 0.5% formic acid acetonitrile solution by ultrasound. The extracted solution was p...
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| Format: | Article |
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The editorial department of Science and Technology of Food Industry
2022-09-01
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| Series: | Shipin gongye ke-ji |
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| Online Access: | http://www.spgykj.com/cn/article/doi/10.13386/j.issn1002-0306.2021110236 |
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| author | Xi WANG Yingru LING Hao ZHANG Wenliang JI |
| author_facet | Xi WANG Yingru LING Hao ZHANG Wenliang JI |
| author_sort | Xi WANG |
| collection | DOAJ |
| description | A method for the determination of 11 organophosphorus flame retardants in baby rice flour was established by ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). The samples were extracted by 0.5% formic acid acetonitrile solution by ultrasound. The extracted solution was purified by dispersive solid phase extraction packing and filtered by polytetrafluoroethylene membrane and detected by UPLC-MS/MS. Gradient elution was carried out with 5 mmol/L ammonium formate and acetonitrile. The target compounds were separated by ACQUITY UPLC® BEH C18 column (100 mm×2.1 mm, 1.7 μm), and multiple response monitoring (MRM) was conducted in the positive electrospray ionization mode. The external standard method was used for quantification. By optimizing chromatographic conditions, all the 11 kinds of organophosphorus flame retardants achieved baseline separation. The 11 kinds of organophosphorus flame retardants had a good linear relationship in the range of 0.5~100 μg/L (Tris (2-ethylhexyl) phosphate 0.05~10 μg/L) with correlation coefficient r>0.994. The limits of detection (3S/N) were 0.003~0.926 μg/kg and the limits of quantitation (10S/N) were 0.01~2.78 μg/kg. The average recoveries at three spiked levels (low, medium and high) were 63.2%~113.4% with the relative standard deviations all less than 10% (n=6). Four kinds of baby rice cereal were analyzed by the established method and the detection rate of triphenyl phosphate (TPhP) was up to 100%. Tributyl phosphate (TnBP) and tris (2-chloroisopropyl) phosphate (TCPP) were also detected in one of the samples. The method could be used for the determination of trace organophosphorus flame retardants in baby rice flour cereal with accurate and reliable results. |
| first_indexed | 2024-04-11T06:52:18Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1002-0306 |
| language | zho |
| last_indexed | 2024-04-11T06:52:18Z |
| publishDate | 2022-09-01 |
| publisher | The editorial department of Science and Technology of Food Industry |
| record_format | Article |
| series | Shipin gongye ke-ji |
| spelling | doaj.art-4f0525f11c6042019df4541b2433ef1f2022-12-22T04:39:08ZzhoThe editorial department of Science and Technology of Food IndustryShipin gongye ke-ji1002-03062022-09-01431729830510.13386/j.issn1002-0306.20211102362021110236-17Determination of 11 Kinds of Organophosphorus Flame Retardants in Baby Rice Cereal by Ultra-high Performance Liquid Chromatography-tandem Mass SpectrometryXi WANG0Yingru LING1Hao ZHANG2Wenliang JI3Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, ChinaJiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, ChinaJiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, ChinaJiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, ChinaA method for the determination of 11 organophosphorus flame retardants in baby rice flour was established by ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). The samples were extracted by 0.5% formic acid acetonitrile solution by ultrasound. The extracted solution was purified by dispersive solid phase extraction packing and filtered by polytetrafluoroethylene membrane and detected by UPLC-MS/MS. Gradient elution was carried out with 5 mmol/L ammonium formate and acetonitrile. The target compounds were separated by ACQUITY UPLC® BEH C18 column (100 mm×2.1 mm, 1.7 μm), and multiple response monitoring (MRM) was conducted in the positive electrospray ionization mode. The external standard method was used for quantification. By optimizing chromatographic conditions, all the 11 kinds of organophosphorus flame retardants achieved baseline separation. The 11 kinds of organophosphorus flame retardants had a good linear relationship in the range of 0.5~100 μg/L (Tris (2-ethylhexyl) phosphate 0.05~10 μg/L) with correlation coefficient r>0.994. The limits of detection (3S/N) were 0.003~0.926 μg/kg and the limits of quantitation (10S/N) were 0.01~2.78 μg/kg. The average recoveries at three spiked levels (low, medium and high) were 63.2%~113.4% with the relative standard deviations all less than 10% (n=6). Four kinds of baby rice cereal were analyzed by the established method and the detection rate of triphenyl phosphate (TPhP) was up to 100%. Tributyl phosphate (TnBP) and tris (2-chloroisopropyl) phosphate (TCPP) were also detected in one of the samples. The method could be used for the determination of trace organophosphorus flame retardants in baby rice flour cereal with accurate and reliable results.http://www.spgykj.com/cn/article/doi/10.13386/j.issn1002-0306.2021110236ultra-high performance liquid chromatography-tandem mass spectrometryorganophosphorus flame retardantsbaby rice cerealtrace amount. |
| spellingShingle | Xi WANG Yingru LING Hao ZHANG Wenliang JI Determination of 11 Kinds of Organophosphorus Flame Retardants in Baby Rice Cereal by Ultra-high Performance Liquid Chromatography-tandem Mass Spectrometry Shipin gongye ke-ji ultra-high performance liquid chromatography-tandem mass spectrometry organophosphorus flame retardants baby rice cereal trace amount. |
| title | Determination of 11 Kinds of Organophosphorus Flame Retardants in Baby Rice Cereal by Ultra-high Performance Liquid Chromatography-tandem Mass Spectrometry |
| title_full | Determination of 11 Kinds of Organophosphorus Flame Retardants in Baby Rice Cereal by Ultra-high Performance Liquid Chromatography-tandem Mass Spectrometry |
| title_fullStr | Determination of 11 Kinds of Organophosphorus Flame Retardants in Baby Rice Cereal by Ultra-high Performance Liquid Chromatography-tandem Mass Spectrometry |
| title_full_unstemmed | Determination of 11 Kinds of Organophosphorus Flame Retardants in Baby Rice Cereal by Ultra-high Performance Liquid Chromatography-tandem Mass Spectrometry |
| title_short | Determination of 11 Kinds of Organophosphorus Flame Retardants in Baby Rice Cereal by Ultra-high Performance Liquid Chromatography-tandem Mass Spectrometry |
| title_sort | determination of 11 kinds of organophosphorus flame retardants in baby rice cereal by ultra high performance liquid chromatography tandem mass spectrometry |
| topic | ultra-high performance liquid chromatography-tandem mass spectrometry organophosphorus flame retardants baby rice cereal trace amount. |
| url | http://www.spgykj.com/cn/article/doi/10.13386/j.issn1002-0306.2021110236 |
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