Prevalence of Musculoskeletal Manifestations in Adult Kidney Transplant’s Recipients: A Systematic Review
<i>Background and Objectives</i>: The musculoskeletal (MSK) manifestations in the kidney transplant recipient (KTxR) could lead to decreased quality of life and increased morbidity and mortality. However, the prevalence of these MSK manifestations is still not well-recognized. This revie...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/57/6/525 |
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| author | Adla B. Hassan Kanz W. Ghalib Haitham A. Jahrami Amgad E. El-Agroudy |
| author_facet | Adla B. Hassan Kanz W. Ghalib Haitham A. Jahrami Amgad E. El-Agroudy |
| author_sort | Adla B. Hassan |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: The musculoskeletal (MSK) manifestations in the kidney transplant recipient (KTxR) could lead to decreased quality of life and increased morbidity and mortality. However, the prevalence of these MSK manifestations is still not well-recognized. This review aimed to investigate the prevalence and outcomes of MSK manifestations in KTxR in the last two decades. <i>Materials and Methods:</i> Research was performed in EBSCO, EMBASE, CINAHL, PubMed/MEDLINE, Cochrane, Google Scholar, PsycINFO, Scopus, Science Direct, and Web of Science electronic databases were searched during the years 2000–2020. <i>Results:</i> The PRISMA flow diagram revealed the search procedure and that 502 articles were retrieved from the initial search and a total of 26 articles were included for the final report in this review. Twelve studies reported bone loss, seven studies reported a bone pain syndrome (BPS) or cyclosporine-induced pain syndrome (CIPS), and seven studies reported hyperuricemia (HU) and gout. The prevalence of MSK manifestations in this review reported as follow: BPS/CIPS ranged from 0.82% to 20.7%, while bone loss ranged from 14% to 88%, and the prevalence of gout reported in three studies as 7.6%, 8.0%, and 22.37%, while HU ranged from 38% to 44.2%. <i>Conclusions:</i> The post-transplantation period is associated with profound MSK abnormalities of mineral metabolism and bone loss mainly caused by corticosteroid therapy, which confer an increased fracture risk. Cyclosporine (CyA) and tacrolimus were responsible for CIPS, while HU or gout was attributable to CyA. Late diagnosis or treatment of post-transplant bone disease is associated with lower quality of life among recipients |
| first_indexed | 2024-03-10T11:07:17Z |
| format | Article |
| id | doaj.art-4f053f50761647b9b3d7105c0d5a119b |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-10T11:07:17Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-4f053f50761647b9b3d7105c0d5a119b2023-11-21T21:01:19ZengMDPI AGMedicina1010-660X1648-91442021-05-0157652510.3390/medicina57060525Prevalence of Musculoskeletal Manifestations in Adult Kidney Transplant’s Recipients: A Systematic ReviewAdla B. Hassan0Kanz W. Ghalib1Haitham A. Jahrami2Amgad E. El-Agroudy3College of Medicine and Medical Sciences, Arabian Gulf University (AGU), 323 Manama, BahrainCollege of Medicine and Medical Sciences, Arabian Gulf University (AGU), 323 Manama, BahrainCollege of Medicine and Medical Sciences, Arabian Gulf University (AGU), 323 Manama, BahrainCollege of Medicine and Medical Sciences, Arabian Gulf University (AGU), 323 Manama, Bahrain<i>Background and Objectives</i>: The musculoskeletal (MSK) manifestations in the kidney transplant recipient (KTxR) could lead to decreased quality of life and increased morbidity and mortality. However, the prevalence of these MSK manifestations is still not well-recognized. This review aimed to investigate the prevalence and outcomes of MSK manifestations in KTxR in the last two decades. <i>Materials and Methods:</i> Research was performed in EBSCO, EMBASE, CINAHL, PubMed/MEDLINE, Cochrane, Google Scholar, PsycINFO, Scopus, Science Direct, and Web of Science electronic databases were searched during the years 2000–2020. <i>Results:</i> The PRISMA flow diagram revealed the search procedure and that 502 articles were retrieved from the initial search and a total of 26 articles were included for the final report in this review. Twelve studies reported bone loss, seven studies reported a bone pain syndrome (BPS) or cyclosporine-induced pain syndrome (CIPS), and seven studies reported hyperuricemia (HU) and gout. The prevalence of MSK manifestations in this review reported as follow: BPS/CIPS ranged from 0.82% to 20.7%, while bone loss ranged from 14% to 88%, and the prevalence of gout reported in three studies as 7.6%, 8.0%, and 22.37%, while HU ranged from 38% to 44.2%. <i>Conclusions:</i> The post-transplantation period is associated with profound MSK abnormalities of mineral metabolism and bone loss mainly caused by corticosteroid therapy, which confer an increased fracture risk. Cyclosporine (CyA) and tacrolimus were responsible for CIPS, while HU or gout was attributable to CyA. Late diagnosis or treatment of post-transplant bone disease is associated with lower quality of life among recipientshttps://www.mdpi.com/1648-9144/57/6/525bone painCyA-induced pain syndromerenal transplantosteoporosismusculoskeletalhyperuricemia |
| spellingShingle | Adla B. Hassan Kanz W. Ghalib Haitham A. Jahrami Amgad E. El-Agroudy Prevalence of Musculoskeletal Manifestations in Adult Kidney Transplant’s Recipients: A Systematic Review Medicina bone pain CyA-induced pain syndrome renal transplant osteoporosis musculoskeletal hyperuricemia |
| title | Prevalence of Musculoskeletal Manifestations in Adult Kidney Transplant’s Recipients: A Systematic Review |
| title_full | Prevalence of Musculoskeletal Manifestations in Adult Kidney Transplant’s Recipients: A Systematic Review |
| title_fullStr | Prevalence of Musculoskeletal Manifestations in Adult Kidney Transplant’s Recipients: A Systematic Review |
| title_full_unstemmed | Prevalence of Musculoskeletal Manifestations in Adult Kidney Transplant’s Recipients: A Systematic Review |
| title_short | Prevalence of Musculoskeletal Manifestations in Adult Kidney Transplant’s Recipients: A Systematic Review |
| title_sort | prevalence of musculoskeletal manifestations in adult kidney transplant s recipients a systematic review |
| topic | bone pain CyA-induced pain syndrome renal transplant osteoporosis musculoskeletal hyperuricemia |
| url | https://www.mdpi.com/1648-9144/57/6/525 |
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